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View article: Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell Differentiation
Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell Differentiation Open
Heparan sulfate (HS) is a heterogeneous, cell-surface polysaccharide critical for transducing signals essential for mammalian development. Imaging of signaling proteins has revealed how their localization influences their information trans…
View article: Virtual screening for small molecule pathway regulators by image profile matching
Virtual screening for small molecule pathway regulators by image profile matching Open
Identifying chemical regulators of biological pathways is a time-consuming bottleneck in developing therapeutics and research compounds. Typically, thousands to millions of candidate small molecules are tested in target-based biochemical s…