Defeng Liu
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View article: Global, regional, and national temporal trends in mortality and disease burden of nasopharyngeal carcinoma attributable to smoking from 1990 to 2021 and predictions to 2040
Global, regional, and national temporal trends in mortality and disease burden of nasopharyngeal carcinoma attributable to smoking from 1990 to 2021 and predictions to 2040 Open
Smoking contributes significantly to the disease burden of NPC, posing a serious threat to public health. Targeted intervention strategies should be implemented according to the regional clustering results of disease burden.
View article: Efficacy and safety of aumolertinib in EGFR-mutated non-small cell lung cancer with leptomeningeal metastasis: a single‑center retrospective study
Efficacy and safety of aumolertinib in EGFR-mutated non-small cell lung cancer with leptomeningeal metastasis: a single‑center retrospective study Open
Aumolertinib showed potential in treating EGFR-mutated NSCLC patients with LM, with a tolerable safety profile.
View article: The Combined Prognostic Value of <sup>18</sup><scp>F</scp>‐<scp>FDG PET/CT</scp> Metabolic Parameters of Immune Organs and Hematological Immune‐Related Markers in Patients With Locally Advanced Cervical Cancer
The Combined Prognostic Value of <sup>18</sup><span>F</span>‐<span>FDG PET/CT</span> Metabolic Parameters of Immune Organs and Hematological Immune‐Related Markers in Patients With Locally Advanced Cervical Cancer Open
Background This study aimed to explore the prognostic value of fluorine‐18 fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F‐FDG PET/CT) metabolic parameters of immune organs and hematological immune‐related marker…
View article: The Role of Lymphocyte Recovery Index in Prognosis Prediction for Locally Advanced Cervical Cancer With Radiation‐Induced Lymphopenia
The Role of Lymphocyte Recovery Index in Prognosis Prediction for Locally Advanced Cervical Cancer With Radiation‐Induced Lymphopenia Open
Background In patients with locally advanced cervical cancer (LACC) undergoing concurrent chemoradiotherapy (CCRT), the high incidence of radiation‐induced lymphopenia significantly affects prognosis. There are significant variations in ly…
View article: Postoperative Adjuvant Therapy Benefits Non‐<scp>pCR</scp> Patients Rather Than <scp>pCR</scp> Patients for Locally Advanced <scp>ESCC</scp>: A Multicenter Real‐World Study
Postoperative Adjuvant Therapy Benefits Non‐<span>pCR</span> Patients Rather Than <span>pCR</span> Patients for Locally Advanced <span>ESCC</span>: A Multicenter Real‐World Study Open
Background There is no unified standard in adjuvant therapy (AT) for patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant therapy and surgery. We evaluated the significance of AT for these patients and explored its inf…
View article: Successful Management of Angiostrongylus Cantonensis‐Induced Eosinophilic Meningitis Using Albendazole–Corticosteroid Therapy: A Case Report With Serial Cytokine and CSF Monitoring
Successful Management of Angiostrongylus Cantonensis‐Induced Eosinophilic Meningitis Using Albendazole–Corticosteroid Therapy: A Case Report With Serial Cytokine and CSF Monitoring Open
Angiostrongylus eosinophilic meningitis is aparasitic disease caused by Angiostrongylus cantonensis . The initial report is originated from southern China. However, the incidence rate has decreased due to improvements in sanitary condition…
View article: The effect of pallidal stimulation on sleep outcomes and related brain connectometries in Parkinson’s disease
The effect of pallidal stimulation on sleep outcomes and related brain connectometries in Parkinson’s disease Open
Sleep difficulties affect up to 98% of Parkinson’s disease (PD) patients and are often not well treated. How globus pallidus internus (GPi)-DBS could help is less understood. We retrospectively analyzed sleep outcomes in 32 PD patients aft…
View article: The role of spleen radiomics model for predicting prognosis in esophageal squamous cell carcinoma patients receiving definitive radiotherapy
The role of spleen radiomics model for predicting prognosis in esophageal squamous cell carcinoma patients receiving definitive radiotherapy Open
Background The spleen plays an important role in systemic antitumor immune response, but whether spleen imaging features have predictive effect for prognosis and immune status was unknown. The aim of this study was to investigate computed …
View article: Inhibitions inflammatory response in clicks alleviates LPS induced myocardial injury by total polysaccharides of Pinus massoniana Lamb. pollen
Inhibitions inflammatory response in clicks alleviates LPS induced myocardial injury by total polysaccharides of Pinus massoniana Lamb. pollen Open
Total polysaccharides of Pinus massoniana Lamb. pollen (PPPSt) is a natural carbohydrate with known anti-inflammatory effects. Inflammation was the main cause of death due to myocardial damage caused by sepsis. The aim of this study was to…
View article: Fronto‐parieto‐subthalamic activity decodes motor status in Parkinson's disease
Fronto‐parieto‐subthalamic activity decodes motor status in Parkinson's disease Open
Aims Patients with Parkinson's disease (PD) have various motor difficulties, including standing up, gait initiation and freezing of gait. These abnormalities are associated with cortico‐subthalamic dysfunction. We aimed to reveal the chara…
View article: Profiling the low-beta characteristics of the subthalamic nucleus in early- and late-onset Parkinson’s disease
Profiling the low-beta characteristics of the subthalamic nucleus in early- and late-onset Parkinson’s disease Open
Objectives Low-beta oscillation (13–20 Hz) has rarely been studied in patients with early-onset Parkinson’s disease (EOPD, age of onset ≤50 years). We aimed to explore the characteristics of low-beta oscillation in the subthalamic nucleus …
View article: Gasless endoscopic thyroidectomy via modified areola approach with a simple flap-lifting technique
Gasless endoscopic thyroidectomy via modified areola approach with a simple flap-lifting technique Open
Objective Studies have shown that carbon dioxide (CO2) insufflation during endoscopic thyroidectomy is associated with many risks. Recently, we have designed a simple lifting tool using Kirschner wire. We aimed to use this tool for flap-li…
View article: Application of the robot-assisted implantation in deep brain stimulation
Application of the robot-assisted implantation in deep brain stimulation Open
Introduction This work aims to assess the accuracy of robotic assistance guided by a videometric tracker in deep brain stimulation (DBS). Methods We retrospectively reviewed a total of 30 DBS electrode implantations, assisted by the Remebo…
View article: Relationship between spinocranial angle and clinical outcomes after laminoplasty in patients with ossification of the posterior longitudinal ligament
Relationship between spinocranial angle and clinical outcomes after laminoplasty in patients with ossification of the posterior longitudinal ligament Open
Background The aims of this study were to identify the relationship between the spinocranial angle (SCA) and clinical outcomes and to explore whether the SCA is a suitable indicator to predict clinical outcomes for patients with ossificati…
View article: Sex modulates the outcome of subthalamic nucleus deep brain stimulation in patients with Parkinson’s disease
Sex modulates the outcome of subthalamic nucleus deep brain stimulation in patients with Parkinson’s disease Open
There are many documented sex differences in the clinical course, symptom expression profile, and treatment response of Parkinson's disease, creating additional challenges for patient management. Although subthalamic nucleus deep brain sti…
View article: Learning to Search in Local Branching
Learning to Search in Local Branching Open
Finding high-quality solutions to mixed-integer linear programming problems (MILPs) is of great importance for many practical applications. In this respect, the refinement heuristic local branching (LB) has been proposed to produce improvi…
View article: Multi-Parameter MR Radiomics Based Model to Predict 5-Year Progression-Free Survival in Endometrial Cancer
Multi-Parameter MR Radiomics Based Model to Predict 5-Year Progression-Free Survival in Endometrial Cancer Open
Background Relapse is the major cause of mortality in patients with resected endometrial cancer (EC). There is an urgent need for a feasible method to identify patients with high risk of relapse. Purpose To develop a multi-parameter magnet…
View article: Cortical phase-amplitude coupling is key to the occurrence and treatment of freezing of gait
Cortical phase-amplitude coupling is key to the occurrence and treatment of freezing of gait Open
Freezing of gait is a debilitating symptom in advanced Parkinson’s disease and responds heterogeneously to treatments such as deep brain stimulation. Recent studies indicated that cortical dysfunction is involved in the development of free…
View article: Synchronized Intracranial Electrical Activity and Gait Recording in Parkinson’s Disease Patients With Freezing of Gait
Synchronized Intracranial Electrical Activity and Gait Recording in Parkinson’s Disease Patients With Freezing of Gait Open
Background This study aimed to describe a synchronized intracranial electroencephalogram (EEG) recording and motion capture system, which was designed to explore the neural dynamics during walking of Parkinson’s disease (PD) patients with …
View article: Surgical Treatment of a Giant Pleomorphic Adenoma of the Submandibular Gland: A Case Report
Surgical Treatment of a Giant Pleomorphic Adenoma of the Submandibular Gland: A Case Report Open
Pleomorphic adenomas (PAs) are the most common benign salivary neoplasms. PAs are generally slow-growing but may sometimes become aggressive and grow rapidly within a short period of time. Here, we report the case of an 83-year-old Chinese…
View article: Predict initial subthalamic nucleus stimulation outcome in Parkinson's disease with brain morphology
Predict initial subthalamic nucleus stimulation outcome in Parkinson's disease with brain morphology Open
Aim Subthalamic nucleus deep brain stimulation (STN‐DBS) has been reported to be effective in treating motor symptoms in Parkinson's disease (PD), which may be attributed to changes in the brain network. However, the association between br…
View article: Automatic Detection Pipeline for Accessing the Motor Severity of Parkinson’s Disease in Finger Tapping and Postural Stability
Automatic Detection Pipeline for Accessing the Motor Severity of Parkinson’s Disease in Finger Tapping and Postural Stability Open
Parkinson’s disease (PD) is a nervous disorder that can cause motor impairment. PD severity assessment based on a series of motor movements illustrated in Unified Parkinson’s Disease Rating Scale (UPDRS) is an important part of clinical PD…
View article: Modulation of the rat hippocampal‐cortex network and episodic‐like memory performance following entorhinal cortex stimulation
Modulation of the rat hippocampal‐cortex network and episodic‐like memory performance following entorhinal cortex stimulation Open
Aims Entorhinal cortex (EC) deep brain stimulation (DBS) has shown a memory enhancement effect. However, its brain network modulation mechanisms remain unclear. The present study aimed to investigate the functional connectivity in the rat …
View article: Comparison of cognitive performance between patients with Parkinson’s disease and dystonia using an intraoperative recognition memory test
Comparison of cognitive performance between patients with Parkinson’s disease and dystonia using an intraoperative recognition memory test Open
Neuroscientific studies on the function of the basal ganglia often examine the behavioral performance of patients with movement disorders, such as Parkinson’s disease (PD) and dystonia (DT), while simultaneously examining the underlying el…
View article: A Positive Feedback Loop of lncRNA MIR31HG-miR-361-3p -YY1 Accelerates Colorectal Cancer Progression Through Modulating Proliferation, Angiogenesis, and Glycolysis
A Positive Feedback Loop of lncRNA MIR31HG-miR-361-3p -YY1 Accelerates Colorectal Cancer Progression Through Modulating Proliferation, Angiogenesis, and Glycolysis Open
Background Colorectal cancer (CRC) is a common malignant tumor with high metastatic and recurrent rates. This study probes the effect and mechanism of long non-coding RNA MIR31HG on the progression of CRC cells. Materials and Methods Quant…