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View article: Quantum algorithm for solving binary hyperelliptic curve discrete logarithm problem
Quantum algorithm for solving binary hyperelliptic curve discrete logarithm problem Open
It is well-established that Shor’s algorithm can solve the discrete logarithm problem (DLP) in polynomial time. The hyperelliptic curve DLP (HCDLP) of genus 2 has found widespread industrial applications and remains an active research doma…
View article: Enoxaparin alleviates preeclampsia by enhancing trophoblast function via the NSUN2-mediated m5C methylation of PAX3 mRNA
Enoxaparin alleviates preeclampsia by enhancing trophoblast function via the NSUN2-mediated m5C methylation of PAX3 mRNA Open
Enoxaparin mitigated PE progression by upregulating NSUN2, which enhanced PAX3 expression via site-specific m5C methylation, thereby improving trophoblast function. The NSUN2/m5C/PAX3 axis represents a novel mechanist…
View article: Correction: Zeng et al. Myricetin Potentiates Antibiotics Against Resistant Pseudomonas aeruginosa by Disrupting Biofilm Formation and Inhibiting Motility Through FimX-Mediated c-di-GMP Signaling Interference. Biology 2025, 14, 859
Correction: Zeng et al. Myricetin Potentiates Antibiotics Against Resistant Pseudomonas aeruginosa by Disrupting Biofilm Formation and Inhibiting Motility Through FimX-Mediated c-di-GMP Signaling Interference. Biology 2025, 14, 859 Open
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View article: Combination therapy with toripalimab and lenvatinib in metastatic type 2 papillary renal cell carcinoma: a Case Report
Combination therapy with toripalimab and lenvatinib in metastatic type 2 papillary renal cell carcinoma: a Case Report Open
Background Type 2 papillary renal cell carcinoma (PRCC) is an aggressive subtype of renal cell carcinoma with a poor prognosis. Diagnosis is challenging, particularly when presenting as a metastatic lung mass. This report describes a case …
View article: Effect of High‐Efficiency Antioxidant on Storage Stability of Constant‐Viscosity Natural Rubber
Effect of High‐Efficiency Antioxidant on Storage Stability of Constant‐Viscosity Natural Rubber Open
Constant‐viscosity natural rubber (CV‐NR) has increased slowly in Mooney viscosity, initial plasticity, and macrogel during long‐term storage. To keep the constant viscosity property stabilizing for a long time, the CV‐NR was prepared by a…
View article: Cyclophosphamide for severe T-DXd-induced interstitial lung disease in low-HER2 breast cancer: a case report and mechanistic insights
Cyclophosphamide for severe T-DXd-induced interstitial lung disease in low-HER2 breast cancer: a case report and mechanistic insights Open
Background Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) that has shown significant efficacy in treating both HER2-positive and low-HER2 breast cancers. However, interstitial lung disease (ILD) remains a major adverse …
View article: Integrated System Development and Experimental Validation of a Hot-Line Tapping Robot for Distribution Line
Integrated System Development and Experimental Validation of a Hot-Line Tapping Robot for Distribution Line Open
To address challenges in distribution network hot-line tapping operations—including topographic constraints, low manual operation accuracy, and high costs of automated equipment—this paper presents a self-lifting hot-line tapping robot. Fe…
View article: Human endogenous retrovirus ERVK3-1 characterizes a metabolically active and immunosuppressive subtype of liver cancer
Human endogenous retrovirus ERVK3-1 characterizes a metabolically active and immunosuppressive subtype of liver cancer Open
View article: Dynamic Risk Assessment of Equipment Operation in Coalbed Methane Gathering Stations Based on the Combination of DBN and CSM Assessment Models
Dynamic Risk Assessment of Equipment Operation in Coalbed Methane Gathering Stations Based on the Combination of DBN and CSM Assessment Models Open
The operational risks of equipment in coalbed methane (CBM) gathering stations exhibit dynamic characteristics. To address this, a dynamic risk assessment method based on Dynamic Bayesian Networks (DBNs) is proposed for CBM station equipme…
View article: Myricetin Potentiates Antibiotics Against Resistant Pseudomonas aeruginosa by Disrupting Biofilm Formation and Inhibiting Motility Through FimX-Mediated c-di-GMP Signaling Interference
Myricetin Potentiates Antibiotics Against Resistant Pseudomonas aeruginosa by Disrupting Biofilm Formation and Inhibiting Motility Through FimX-Mediated c-di-GMP Signaling Interference Open
Pseudomonas aeruginosa biofilm formation is critical to antibiotic resistance and persistence. Targeting cyclic di-GMP (c-di-GMP) signaling, a master biofilm formation and virulence regulator, presents a promising strategy to combat resist…
View article: Esophageal cancer trends in the US from 1992 to 2019 with projections to 2044 using SEER data
Esophageal cancer trends in the US from 1992 to 2019 with projections to 2044 using SEER data Open
Esophageal adenocarcinoma (EAC) has increased substantially to become the most common type of esophageal cancer in the United States, surpassing esophageal squamous cell carcinoma (ESCC). Whether the increasing incidence of EAC is linked t…
View article: Disulfidptosis, a novel regulated cell death to predict survival and therapeutic response in kidney renal clear cell carcinoma
Disulfidptosis, a novel regulated cell death to predict survival and therapeutic response in kidney renal clear cell carcinoma Open
View article: Identification of Potential <scp>PBP2a</scp> Inhibitors Against Methicillin‐Resistant <scp><i>Staphylococcus aureus</i></scp> via Drug Repurposing and Combination Therapy
Identification of Potential <span>PBP2a</span> Inhibitors Against Methicillin‐Resistant <span><i>Staphylococcus aureus</i></span> via Drug Repurposing and Combination Therapy Open
Methicillin‐resistant Staphylococcus aureus (MRSA) achieves high‐level resistance against β‐lactam antibiotics through the expression of penicillin‐binding protein 2a (PBP2a), which features a closed active site that impedes antibiotic bin…
View article: Synergistic Effects of Pyrrosia lingua Caffeoylquinic Acid Compounds with Levofloxacin Against Uropathogenic Escherichia coli: Insights from Molecular Dynamics Simulations, Antibiofilm, and Antimicrobial Assessments
Synergistic Effects of Pyrrosia lingua Caffeoylquinic Acid Compounds with Levofloxacin Against Uropathogenic Escherichia coli: Insights from Molecular Dynamics Simulations, Antibiofilm, and Antimicrobial Assessments Open
Urinary tract infections (UTIs), primarily caused by uropathogenic Escherichia coli (UPEC), have high morbidity and recurrence rates. Resistance to levofloxacin hydrochloride (LEV), a commonly used treatment for UTIs, is increasingly probl…
View article: RNA-binding proteins in breast cancer: Biological implications and therapeutic opportunities
RNA-binding proteins in breast cancer: Biological implications and therapeutic opportunities Open
RNA-binding proteins (RBPs) refer to a class of proteins that participate in alternative splicing, RNA stability, polyadenylation, localization and translation of RNAs, thus regulating gene expression in post-transcriptional manner. Dysreg…
View article: HER2-targeting two-dimensional black phosphorus as a nanoplatform for chemo-photothermal therapy in breast cancer
HER2-targeting two-dimensional black phosphorus as a nanoplatform for chemo-photothermal therapy in breast cancer Open
View article: Endogenous retrovirus group FRD member 1 is a potential biomarker for prognosis and immunotherapy for kidney renal clear cell carcinoma
Endogenous retrovirus group FRD member 1 is a potential biomarker for prognosis and immunotherapy for kidney renal clear cell carcinoma Open
Introduction The activation of endogenous retroviral (ERV) genes in kidney renal clear cell carcinoma (KIRC) suggests the necessity for further research on their functions. Methods In this study, KIRC and healthy cohorts were obtained from…
View article: Prevalence and factors of COVID-19 vaccine refusal among solid cancer patients in China: an application of the health belief model
Prevalence and factors of COVID-19 vaccine refusal among solid cancer patients in China: an application of the health belief model Open
Introduction It is essential to protect cancer patients from contracting COVID-19 through vaccination. A majority of cancer patients are recommended by international health authorities to take up the vaccines. COVID-19 vaccine refusal amon…
View article: Notch1 promotes resistance to cisplatin by up-regulating Ecto-5′-nucleotidase (CD73) in triple-negative breast cancer cells
Notch1 promotes resistance to cisplatin by up-regulating Ecto-5′-nucleotidase (CD73) in triple-negative breast cancer cells Open
Triple-negative breast cancer (TNBC) is an aggressive molecular subtype that due to lack of druggable targets is treated with chemotherapy as standard of care. However, TNBC is prone to chemoresistance and associates with poor survival. Th…
View article: Online short videos promoting public breast cancer literacy: a pretest-posttest control group trial on efficiency, attitude, and influencing factors
Online short videos promoting public breast cancer literacy: a pretest-posttest control group trial on efficiency, attitude, and influencing factors Open
Background Short videos on social media are playing an increasingly important role in cancer health education today. It is important to explore how the actual communication effect of health videos and the knowledge absorption of users are …
View article: Notch3 Transactivates Glycogen Synthase Kinase-3-Beta and Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer Cells
Notch3 Transactivates Glycogen Synthase Kinase-3-Beta and Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer Cells Open
As a critical transformational process in the attributes of epithelial cells, epithelial-to-mesenchymal transition (EMT) is involved in tumor invasion, metastasis, and resistance to treatment, which contributes to the ultimate death of som…
View article: CD146 interaction with integrin β1 activates LATS1-YAP signaling and induces radiation-resistance in breast cancer cells
CD146 interaction with integrin β1 activates LATS1-YAP signaling and induces radiation-resistance in breast cancer cells Open
Radiotherapy is an indispensable modality in comprehensive treatment of breast cancer. However, inherent or acquired radiation resistance of tumors compromises the efficacy of radiotherapy. Herein, we found that CD146, a unique epithelial-…
View article: Associations of Obesity, Physical Activity, and Screening With State-Level Trends and Racial and Ethnic Disparities of Breast Cancer Incidence and Mortality in the US
Associations of Obesity, Physical Activity, and Screening With State-Level Trends and Racial and Ethnic Disparities of Breast Cancer Incidence and Mortality in the US Open
The findings of this cross-sectional study suggest that racial and ethnic disparities exist at the state level with regard to breast cancer incidence and mortality among women in the US. Metabolic and lifestyle factors and screening access…
View article: Notch3 Inhibits Epithelial-to-Mesenchymal Transition by Transactivating Glycogen Synthase Kinase-3-beta–Mediated Wnt/β-catenin Signaling in Breast Cancer
Notch3 Inhibits Epithelial-to-Mesenchymal Transition by Transactivating Glycogen Synthase Kinase-3-beta–Mediated Wnt/β-catenin Signaling in Breast Cancer Open
As a critical transformational process in the attributes of epithelial cells, epithelial-to-mesenchymal transition (EMT) is involved in tumor invasion, metastasis, and resistance to treatment, which contributes to the ultimate death of som…
View article: FBLN5 Is an Underlying Common Tumor Suppressor in Breast Cancer and Thyroid Cancer
FBLN5 Is an Underlying Common Tumor Suppressor in Breast Cancer and Thyroid Cancer Open
Background: Breast cancer (BC) patients have a greater risk of developing thyroid cancer (TC) than the general population. Similarly, TC patients are more likely to develop BC, suggesting an underlying common etiology. In this study, we so…
View article: CXCL9 Is a Potential Biomarker of Immune Infiltration Associated With Favorable Prognosis in ER-Negative Breast Cancer
CXCL9 Is a Potential Biomarker of Immune Infiltration Associated With Favorable Prognosis in ER-Negative Breast Cancer Open
The chemokine CXCL9 (C-X-C motif chemokine ligand 9) has been reported to be required for antitumour immune responses following immune checkpoint blockade. In this study, we sought to investigate the potential value of CXCL9 according to i…
View article: Notch3 inhibits cell proliferation and tumorigenesis and predicts better prognosis in breast cancer through transactivating PTEN
Notch3 inhibits cell proliferation and tumorigenesis and predicts better prognosis in breast cancer through transactivating PTEN Open
Notch receptors (Notch1–4) play critical roles in tumorigenesis and metastasis of malignant tumors, including breast cancer. Although abnormal Notch activation is related to various tumors, the importance of single receptors and their mech…
View article: Breast Cancer Incidence and Mortality Trends, Variation by State and Race/Ethnicity, and Association With Obesity, Physical Activity, and Mammography Screening in the United States
Breast Cancer Incidence and Mortality Trends, Variation by State and Race/Ethnicity, and Association With Obesity, Physical Activity, and Mammography Screening in the United States Open
View article: A negative binomial regression model for risk estimation of 0–2 axillary lymph node metastases in breast cancer patients
A negative binomial regression model for risk estimation of 0–2 axillary lymph node metastases in breast cancer patients Open
Extensive clinical trials indicate that patients with negative sentinel lymph node biopsy do not need axillary lymph node dissection (ALND). However, the ACOSOG Z0011 trial indicates that patients with clinically negative axillary lymph no…
View article: FABP7 is a potential biomarker to predict response to neoadjuvant chemotherapy for breast cancer
FABP7 is a potential biomarker to predict response to neoadjuvant chemotherapy for breast cancer Open
Background Early prediction of response to neoadjuvant chemotherapy (NAC) is critical in choosing appropriate chemotherapeutic regimen for patients with locally advanced breast cancer. Herein, we sought to identify potential biomarkers to …