Defu Hu
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View article: Survival and pathological response in pancreatic ductal adenocarcinoma after preoperative therapy with PD-1 blockade plus chemoradiotherapy followed by surgical resection
Survival and pathological response in pancreatic ductal adenocarcinoma after preoperative therapy with PD-1 blockade plus chemoradiotherapy followed by surgical resection Open
NAT with PD-1 blockade plus chemoradiotherapy was associated with a higher CPR rate in resected PDAC. Age and tumor size decrease were predictive factors for PR. PV/SMV invasion, resectability status, and preoperative CA 19-9 levels were i…
View article: Hair Metabolomic Profiling of Diseased Forest Musk Deer (Moschus berezovskii) Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry (UHPLC-MS/MS)
Hair Metabolomic Profiling of Diseased Forest Musk Deer (Moschus berezovskii) Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry (UHPLC-MS/MS) Open
Hair, as a non-invasive biospecimen, retains metabolic deposits from sebaceous glands and capillaries, reflecting substances from the peripheral circulation, and provides valuable biochemical information linked to phenotypes, yet its appli…
View article: The first mitogenome of Petrovinema skrjabini from Equus ferus przewalskii: a phylogenetic analysis within the Strongylidae family
The first mitogenome of Petrovinema skrjabini from Equus ferus przewalskii: a phylogenetic analysis within the Strongylidae family Open
Background Petrovinema skrjabini (Nematoda: Strongylidae, Cyathostominae) is a parasitic nematode colonizing the cecum and colon of equids. Like other cyathostomins, its larvae (L3) invade the intestinal mucosa, forming encysted nodules th…
View article: Histological and histochemical characterization of the musk gland in forest musk deer (<i>Moschus berezovskii</i>): a preliminary study
Histological and histochemical characterization of the musk gland in forest musk deer (<i>Moschus berezovskii</i>): a preliminary study Open
Musk is a biologically valuable secretion from the musk gland of male musk deer, with significant economic and medicinal importance. Due to severe decline and depletion of wild musk deer population, captive breeding of musk deer has become…
View article: Genetic Erosion in Captive Alpine Musk Deer Highlights the Challenges of Conserving Endangered Species in Closed Populations
Genetic Erosion in Captive Alpine Musk Deer Highlights the Challenges of Conserving Endangered Species in Closed Populations Open
The alpine musk deer (Moschus chrysogaster) is a critically endangered species in China whose wild populations have precipitously declined due to habitat degradation and poaching. In response, China established the world’s first captive br…
View article: Variations in Intestinal Microbiota Among Three Species in the Cervidae Family Under the Same Feeding Conditions
Variations in Intestinal Microbiota Among Three Species in the Cervidae Family Under the Same Feeding Conditions Open
The breeding of large animals in the family Cervidae in China contributes to achieving two tasks: restoring the provenance of wild populations and providing raw materials for traditional Chinese medicine. Currently, red deer (Cervus elaphu…
View article: Defecation Site Preferences and Spatial Ecological Segregation of Forest Musk Deer and Siberian Roe Deer in North China
Defecation Site Preferences and Spatial Ecological Segregation of Forest Musk Deer and Siberian Roe Deer in North China Open
The forest musk deer (Moschus berezovskii) and Siberian roe deer (Capreolus pygargus) are browsers with a broad sympatric distribution in North and Southwest China. However, little is known about their spatial utilization of microhabitats …
View article: An Investigation of the Saccharides Profile and Metabolic Gene Expression in Muskrat Scented Glands in Different Secretion Seasons
An Investigation of the Saccharides Profile and Metabolic Gene Expression in Muskrat Scented Glands in Different Secretion Seasons Open
The adult male muskrat has a pair of scented glands, which show clear seasonal changes in their developmental status between the secretion season and non-secretion season. During the secretion season, the scented glands are much larger tha…
View article: Assessing Fecal Microbial Diversity and Hormone Levels as Indicators of Gastrointestinal Health in Reintroduced Przewalski’s Horses (Equus ferus przewalskii)
Assessing Fecal Microbial Diversity and Hormone Levels as Indicators of Gastrointestinal Health in Reintroduced Przewalski’s Horses (Equus ferus przewalskii) Open
Diarrhea serves as a vital health indicator for assessing wildlife populations post-reintroduction. Upon release into the wild, wild animals undergo adaptation to diverse habitats and dietary patterns. While such changes prompt adaptive re…
View article: Gut microbiome reveals contrasting enterotypes and health statuses of semi-wild Saiga antelopes (Saiga tatarica)
Gut microbiome reveals contrasting enterotypes and health statuses of semi-wild Saiga antelopes (Saiga tatarica) Open
Gut microbiome studies based on fecal samples can non-invasively reflect the survival and health status of endangered species. This study presents the first characterization of the gut microbiome in the semi-wild population of the critical…
View article: Nutritional Partitioning among Sympatric Ungulates in Eastern Tibet
Nutritional Partitioning among Sympatric Ungulates in Eastern Tibet Open
Wild ungulates play crucial roles in maintaining the structure and function of local ecosystems. The alpine musk deer (Moschus chrysogaste), white-lipped deer (Przewalskium albirostris), and red serow (Capricornis rubidus) are widely distr…
View article: Analysis on Changes and Influencing Factors of the Intestinal Microbiota of Alpine Musk Deer between the Place of Origin and Migration
Analysis on Changes and Influencing Factors of the Intestinal Microbiota of Alpine Musk Deer between the Place of Origin and Migration Open
In China, the population of wild musk deer, belonging to the family Moschidae, has drastically decreased in recent years owing to human activities and environmental changes. During the 1990s, artificial breeding of Alpine musk deer was con…
View article: First report of four rare strongylid species infecting endangered Przewalski’s horses (Equus ferus przewalskii) in Xinjiang, China
First report of four rare strongylid species infecting endangered Przewalski’s horses (Equus ferus przewalskii) in Xinjiang, China Open
Background The Przewalski's horse ( Equus ferus przewalskii ) is the only surviving wild horse species in the world. A significant population of Przewalski's horses resides in Xinjiang, China. Parasitosis poses a considerable threat to the…
View article: Detecting Forest Musk Deer Abscess Disease Pathogens Using 16S rRNA High-Throughput Sequencing Technology
Detecting Forest Musk Deer Abscess Disease Pathogens Using 16S rRNA High-Throughput Sequencing Technology Open
Currently, researchers use bacterial culture and targeted PCR methods to classify, culture, and identify the pathogens causing abscess diseases. However, this method is limited by factors such as the type of culture medium and culture cond…
View article: mtDNA CR Evidence Indicates High Genetic Diversity of Captive Forest Musk Deer in Shaanxi Province, China
mtDNA CR Evidence Indicates High Genetic Diversity of Captive Forest Musk Deer in Shaanxi Province, China Open
Forest musk deer (Moschus berezovskii) are endangered ruminants whose adult males secrete musk. China has been breeding forest musk deer artificially since the 1950s in an effort to restore wild populations, with Shaanxi and Sichuan provin…
View article: Effects of different weaning times on the stress response and the intestinal microbiota composition of female forest musk deer (Moschus berezovskii) and their fawns
Effects of different weaning times on the stress response and the intestinal microbiota composition of female forest musk deer (Moschus berezovskii) and their fawns Open
The effects of mother-infant separation (i.e., weaning) on the physiology, psychology and nutrition of mammalian infants have attracted much attention. Forest musk deer (FMD) is a first-class protected species in China and listed endangere…
View article: Population genomics reveals moderate genetic differentiation between populations of endangered Forest Musk Deer located in Shaanxi and Sichuan
Population genomics reveals moderate genetic differentiation between populations of endangered Forest Musk Deer located in Shaanxi and Sichuan Open
Background Many endangered species exist in small, genetically depauperate, or inbred populations, hence promoting genetic differentiation and reducing long-term population viability. Forest Musk Deer ( Moschus berezovskii ) has been subje…
View article: Changes in the gut microbiota of forest musk deer (Moschus berezovskii) during ex situ conservation
Changes in the gut microbiota of forest musk deer (Moschus berezovskii) during ex situ conservation Open
Ex situ conservation is an important technique for protecting rare and endangered wildlife, and maintaining stable individual health is crucial to its success. Gut microbiota composition is a critical indicator of animal health and should …
View article: Wild and Captive Environments Drive the Convergence of Gut Microbiota and Impact Health in Threatened Equids
Wild and Captive Environments Drive the Convergence of Gut Microbiota and Impact Health in Threatened Equids Open
To explore how the living environment influences the establishment of gut microbiota in different species, as well as the extent to which changes in the living environment caused by captive breeding affect wildlife’s gut microbiota and hea…
View article: Comparative Analysis of Microbiome Metagenomics in Reintroduced Wild Horses and Resident Asiatic Wild Asses in the Gobi Desert Steppe
Comparative Analysis of Microbiome Metagenomics in Reintroduced Wild Horses and Resident Asiatic Wild Asses in the Gobi Desert Steppe Open
The gut microbiome offers important ecological benefits to the host; however, our understanding of the functional microbiome in relation to wildlife adaptation, especially for translocated endangered species, is lagging. In this study, we …
View article: Major Histocompatibility Complex (MHC) Diversity of the Reintroduction Populations of Endangered Przewalski’s Horse
Major Histocompatibility Complex (MHC) Diversity of the Reintroduction Populations of Endangered Przewalski’s Horse Open
Major histocompatibility complex (MHC) genes are the most polymorphic in vertebrates and the high variability in many MHC genes is thought to play a crucial role in pathogen recognition. The MHC class II locus DQA polymorphism was analyzed…
View article: Breeding Population Dynamics of Relict Gull (Larus relictus) in Hongjian Nur, Shaanxi, China
Breeding Population Dynamics of Relict Gull (Larus relictus) in Hongjian Nur, Shaanxi, China Open
Hongjian Nur is an important breeding and stopover area for the globally endangered Relict gull (Larus relictus). This is where the species was first found in 2000. The breeding population of this species was monitored over the long term b…
View article: Effects of different weaning times on the stress response and the intestinal microbiota composition of female forest musk deer (Moschus berezovskii) and their fawns
Effects of different weaning times on the stress response and the intestinal microbiota composition of female forest musk deer (Moschus berezovskii) and their fawns Open
Metagenome sequencing and enzyme-linked immunosorbent assays were used to study changes in the fecal cortisol concentration, as well as the intestinal microbiome composition and function of females and fawns at three different separation t…
View article: Genetic Differentiation of Reintroduced Père David’s Deer (Elaphurus davidianus) Based on Population Genomics Analysis
Genetic Differentiation of Reintroduced Père David’s Deer (Elaphurus davidianus) Based on Population Genomics Analysis Open
The reintroduction is an important conservation tool to restore a species in its historically distribution area, but the rate of reintroduction success varies across species or regions due to different reasons. Genetic evaluation is import…