Dehua Chui
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View article: Neural mechanisms of top-down divided and selective spatial attention in visual and auditory perception
Neural mechanisms of top-down divided and selective spatial attention in visual and auditory perception Open
Top-down attention mechanisms require the selection of specific objects or locations; however, the brain mechanism involved when attention is allocated across different modalities is not well understood. The aim of this study was to use fu…
View article: Stimulation Modeling on Three-Dimensional Anisotropic Diffusion of MRI Tracer in the Brain Interstitial Space
Stimulation Modeling on Three-Dimensional Anisotropic Diffusion of MRI Tracer in the Brain Interstitial Space Open
Purpose: To build a mathematical model based magnetic resonance (MR) method to simulate drug anisotropic distribution in vivo in the interstitial space (ISS) of the brain. Materials and Methods: An injection of signal intensity-related gad…
View article: Dapsone protects brain microvascular integrity from high-fat diet induced LDL oxidation
Dapsone protects brain microvascular integrity from high-fat diet induced LDL oxidation Open
Atherosclerosis was considered to induce many vascular-related complications, such as acute myocardial infarction and stroke. Abnormal lipid metabolism and its peroxidation inducing blood–brain barrier (BBB) leakage were associated with th…
View article: Prophylactic Melatonin Attenuates Isoflurane‐Induced Cognitive Impairment in Aged Rats through Hippocampal Melatonin Receptor 2 – cAMP Response Element Binding Signalling
Prophylactic Melatonin Attenuates Isoflurane‐Induced Cognitive Impairment in Aged Rats through Hippocampal Melatonin Receptor 2 – cAMP Response Element Binding Signalling Open
Melatonin exerts many physiological effects via melatonin receptors, among which the melatonin‐2 receptor ( MT 2 ) plays a critical role in circadian rhythm disorders, Alzheimer's disease and other neurological disorders. A melatonin repla…
View article: Increased extrasynaptic GluN2B expression is involved in cognitive impairment after isoflurane anesthesia
Increased extrasynaptic GluN2B expression is involved in cognitive impairment after isoflurane anesthesia Open
There is increasing concern regarding the postoperative cognitive dysfunction (POCD) in the aging population, and general anesthetics are believed to be involved. Isoflurane exposure induced increased N-methyl-D-aspartic acid receptor (NMD…
View article: Surgery-Induced Hippocampal Angiotensin II Elevation Causes Blood-Brain Barrier Disruption via MMP/TIMP in Aged Rats
Surgery-Induced Hippocampal Angiotensin II Elevation Causes Blood-Brain Barrier Disruption via MMP/TIMP in Aged Rats Open
Reversible blood-brain barrier (BBB) disruption has been uniformly reported in several animal models of postoperative cognitive dysfunction (POCD). Nevertheless, the precise mechanism underlying this occurrence remains unclear. Using an ag…