Deirdre Cunningham
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View article: De novo assembly of plasmodium interspersed repeat (pir) genes from Plasmodium vivax RNAseq data suggests geographic conservation of sub-family transcription
De novo assembly of plasmodium interspersed repeat (pir) genes from Plasmodium vivax RNAseq data suggests geographic conservation of sub-family transcription Open
Background: The plasmodium interspersed repeats (pir) multigene family is found across malaria parasite genomes, first discovered in the human-infecting species Plasmodium vivax, where they were initially named the virs. Their function rem…
View article: Differential Response and Recovery Dynamics of HSPC Populations Following Plasmodium chabaudi Infection
Differential Response and Recovery Dynamics of HSPC Populations Following Plasmodium chabaudi Infection Open
Severe infections such as malaria are on the rise worldwide, driven by both climate change and increasing drug resistance. It is therefore paramount that we better understand how the host responds to severe infection. Hematopoiesis is part…
View article: Differential responses and recovery dynamics of HSPC populations following<i>Plasmodium chabaudi</i>infection
Differential responses and recovery dynamics of HSPC populations following<i>Plasmodium chabaudi</i>infection Open
Severe infections such as malaria are on the rise worldwide, driven by both climate change and increasing drug-resistance. It is therefore paramount that we better understand how the host’s organism responds to severe infection. Hematopoie…
View article: O04 Reintroducing pen and leaving quin-alone: examining the impact of a penicillin allergy de-labelling project on antibiotic prescribing in a hospital setting
O04 Reintroducing pen and leaving quin-alone: examining the impact of a penicillin allergy de-labelling project on antibiotic prescribing in a hospital setting Open
Background The label of penicillin allergy is carried by between 8 and 25% of all patients (1). Alternative antibiotics may not be as efficacious, can be more expensive and lead to more adverse effects (2). Interrogation of a penicillin al…
View article: Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS
Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS Open
Objective To analyse the transcriptional profiles of the pir multigene family of Plasmodium chabaudi chabaudi in male and female gametocytes isolated from the blood of infected mice. Results Infected red blood cells containing female and m…
View article: Differential Trafficking and Expression of PIR Proteins in Acute and Chronic Plasmodium Infections
Differential Trafficking and Expression of PIR Proteins in Acute and Chronic Plasmodium Infections Open
Plasmodium multigene families are thought to play important roles in the pathogenesis of malaria. Plasmodium interspersed repeat (pir) genes comprise the largest multigene family in many Plasmodium species. However, their expression patter…
View article: Editorial: Malaria Targeting Toolkit: Host-Parasite Interactions
Editorial: Malaria Targeting Toolkit: Host-Parasite Interactions Open
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View article: Analysis of Pir Gene Expression Across the Plasmodium Life Cycle
Analysis of Pir Gene Expression Across the Plasmodium Life Cycle Open
Background Plasmodium interspersed repeat ( pir ) is the largest multigene family in the genomes of most Plasmodium species. A variety of functions for the PIR proteins which they encode have been proposed, including antigenic variation, i…
View article: Additional file 5 of Analysis of pir gene expression across the Plasmodium life cycle
Additional file 5 of Analysis of pir gene expression across the Plasmodium life cycle Open
Additional file 5. P. c. chabaudi counts across the 24 hour asexual developmental cycle.
View article: Additional file 1 of Analysis of pir gene expression across the Plasmodium life cycle
Additional file 1 of Analysis of pir gene expression across the Plasmodium life cycle Open
Additional file 1. Re-analysed counts of the P. berghei data from the studies listed in Table 2.
View article: Additional file 14 of Analysis of pir gene expression across the Plasmodium life cycle
Additional file 14 of Analysis of pir gene expression across the Plasmodium life cycle Open
Additional file 14. Table of contents of additional files 1–6.
View article: Additional file 4 of Analysis of pir gene expression across the Plasmodium life cycle
Additional file 4 of Analysis of pir gene expression across the Plasmodium life cycle Open
Additional file 4. Statistics of P. berghei individual pir genes (DESeq).
View article: Additional file 2 of Analysis of pir gene expression across the Plasmodium life cycle
Additional file 2 of Analysis of pir gene expression across the Plasmodium life cycle Open
Additional file 2. P. berghei pirgene information, TPM values for individual samples and combined across life cycle stages, and summed across sub-families, chromosomes and loci.
View article: Additional file 16 of Analysis of pir gene expression across the Plasmodium life cycle
Additional file 16 of Analysis of pir gene expression across the Plasmodium life cycle Open
Additional file 16: Table S1. The relationship between P. chabaudi RNA-seq samples used in this study and their entries in the ENA is described.
View article: Additional file 6 of Analysis of pir gene expression across the Plasmodium life cycle
Additional file 6 of Analysis of pir gene expression across the Plasmodium life cycle Open
Additional file 6. P.c. chabaudi parasitaemia, pir gene information, TPM values, summed across loci, and z-scores.
View article: Additional file 3 of Analysis of pir gene expression across the Plasmodium life cycle
Additional file 3 of Analysis of pir gene expression across the Plasmodium life cycle Open
Additional file 3. Statistics of P. berghei pirgene set comparisons (QUSage).
View article: Structure of the <i>Plasmodium</i> -interspersed repeat proteins of the malaria parasite
Structure of the <i>Plasmodium</i> -interspersed repeat proteins of the malaria parasite Open
Significance The Plasmodium parasites that cause malaria replicate within blood cells of an infected host. These parasites send a small number of proteins to infected blood cell surfaces, allowing them to bind host molecules but also riski…
View article: Transcriptome analysis of blood and spleen in virulent and avirulent mouse malaria infection
Transcriptome analysis of blood and spleen in virulent and avirulent mouse malaria infection Open
Malaria is a devastating infectious disease and the immune response is complex and dynamic during a course of a malarial infection. Rodent malaria models allow detailed time-series studies of the host response in multiple organs. Here, we …
View article: An enhanced toolkit for the generation of knockout and marker-free fluorescent Plasmodium chabaudi
An enhanced toolkit for the generation of knockout and marker-free fluorescent Plasmodium chabaudi Open
The rodent parasite Plasmodium chabaudi is an important in vivo model of malaria. The ability to produce chronic infections makes it particularly useful for investigating the development of anti-Plasmodium immunity, as well as features ass…
View article: An enhanced toolkit for the generation of knockout and marker-free fluorescent Plasmodium chabaudi
An enhanced toolkit for the generation of knockout and marker-free fluorescent Plasmodium chabaudi Open
The rodent parasite Plasmodium chabaudi is an important in vivo model of malaria. The ability to produce chronic infections makes it particularly useful for investigating the development of anti-Plasmodium immunity, as well as features ass…
View article: Neutrophil extracellular traps drive inflammatory pathogenesis in malaria
Neutrophil extracellular traps drive inflammatory pathogenesis in malaria Open
NETs contribute to malaria by promoting emergency granulopoiesis and endothelial binding of parasitized erythrocytes.
View article: Genomic and transcriptomic comparisons of closely related malaria parasites differing in virulence and sequestration pattern
Genomic and transcriptomic comparisons of closely related malaria parasites differing in virulence and sequestration pattern Open
Background: Malaria parasite species differ greatly in the harm they do to humans. While P. falciparum kills hundreds of thousands per year, P. vivax kills much less often and P. malariae is relatively benign. Strains of the rodent malaria…
View article: Genomic and transcriptomic comparisons of closely related malaria parasites differing in virulence and sequestration pattern
Genomic and transcriptomic comparisons of closely related malaria parasites differing in virulence and sequestration pattern Open
Background: Malaria parasite species differ greatly in the harm they do to humans. While P. falciparum kills hundreds of thousands per year, P. vivax kills much less often and P. malariae is relatively benign. Strains of the rodent malaria…