Dejana Jovicevic
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View article: Synthetic yeast chromosome XI design provides a testbed for the study of extrachromosomal circular DNA dynamics
Synthetic yeast chromosome XI design provides a testbed for the study of extrachromosomal circular DNA dynamics Open
We describe construction of the synthetic yeast chromosome XI (synXI) and reveal the effects of redesign at non-coding DNA elements. The 660-kb synthetic yeast genome project (Sc2.0) chromosome was assembled from synthesized DNA fra…
View article: Synthetic yeast chromosome XI design enables extrachromosomal circular DNA formation on demand
Synthetic yeast chromosome XI design enables extrachromosomal circular DNA formation on demand Open
Summary We describe construction of the 660 kilobase synthetic yeast chromosome XI ( synXI ) and reveal how synthetic redesign of non-coding DNA elements impact the cell. To aid construction from synthesized 5 to 10 kilobase DNA fragments,…
View article: Rapid genome surveillance of SARS-CoV-2 and study of risk factors using shipping container laboratories and portable DNA sequencing technology
Rapid genome surveillance of SARS-CoV-2 and study of risk factors using shipping container laboratories and portable DNA sequencing technology Open
In this paper we report on genome sequencing of 154 SARS-CoV-2 samples between June and July 2021 (Summer outbreak) in the Bailiwick of Jersey, a UK channel island. We have analysed extensive data collected on 598,155 RT-qPCR tests that id…
View article: N‐Terminal Modification of Gly‐His‐Tagged Proteins with Azidogluconolactone
N‐Terminal Modification of Gly‐His‐Tagged Proteins with Azidogluconolactone Open
Site‐specific protein modifications are vital for biopharmaceutical drug development. Gluconoylation is a non‐enzymatic, post‐translational modification of N‐terminal HisTags. We report high‐yield, site‐selective in vitro α‐aminoacylation …
View article: Rapid host strain improvement by in vivo rearrangement of a synthetic yeast chromosome
Rapid host strain improvement by in vivo rearrangement of a synthetic yeast chromosome Open
View article: Developing a synthetic yeast for the expression of heterologous genes using SCRaMbLE
Developing a synthetic yeast for the expression of heterologous genes using SCRaMbLE Open
Synthetic genomics is a new and fast emerging multi-disciplinary field of research, representing the largest scale of work underway in synthetic biology. The Saccharomyces cerevisiae version 2 (Sc2.0) project is currently the leading examp…