Deju Zhang
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View article: The emerging role of extracellular vesicles in diabetes and complications: mechanistic insights and translational prospects
The emerging role of extracellular vesicles in diabetes and complications: mechanistic insights and translational prospects Open
Extracellular vesicles (EVs), particularly exosomes, have emerged as key players in diabetes pathogenesis, diagnosis, and therapy. They regulate intercellular communication, influence islet function, and contribute to diabetic complication…
View article: Corrigendum to “Regulation of NcRNA-protein binding in diabetic foot” [Biomed. Pharmacother. 160 (2023) 114361]
Corrigendum to “Regulation of NcRNA-protein binding in diabetic foot” [Biomed. Pharmacother. 160 (2023) 114361] Open
View article: Medicine‐Food Plant Polysaccharides Modulate Diabetes and Diabetic Complications Through Maintaining Gut Function: A Review
Medicine‐Food Plant Polysaccharides Modulate Diabetes and Diabetic Complications Through Maintaining Gut Function: A Review Open
Diabetes and its complications cause serious global health and economic burdens. Various medicine‐food plant polysaccharides (MFPPs) have garnered increasing attention due to their low toxicity, minimal side effects, and efficacy in suppre…
View article: Association between Systemic Immune-Inflammation Index and female breast cancer based on NHANES data (2001–2018): A cross-sectional study
Association between Systemic Immune-Inflammation Index and female breast cancer based on NHANES data (2001–2018): A cross-sectional study Open
Worldwide cancer statistics have shown that breast cancer dominates female cancer incidence and remains a leading cause of death. The Systemic Immune-Inflammation Index (SII) is a new prognostic indicator of systemic inflammation used to a…
View article: Pea-Derived Antioxidant Peptides: Applications, Bioactivities, and Mechanisms in Oxidative Stress Management
Pea-Derived Antioxidant Peptides: Applications, Bioactivities, and Mechanisms in Oxidative Stress Management Open
Chronic injuries and diseases related to oxidative stress are major global concerns as they impose a great medical burden and lead to serious public health issues. Antioxidant peptides derived from pea protein can serve as potent antioxida…
View article: Gamma-aminobutyric acid-enriched fermented camel whey protein ameliorate breast cancer-induced fatigue in mice via reshaping gut microbiota and modulating SCFA metabolism
Gamma-aminobutyric acid-enriched fermented camel whey protein ameliorate breast cancer-induced fatigue in mice via reshaping gut microbiota and modulating SCFA metabolism Open
View article: Prognostic value of FIB-4 and NFS for cardiovascular events in patients with and without NAFLD
Prognostic value of FIB-4 and NFS for cardiovascular events in patients with and without NAFLD Open
Background The association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) is well studied. Liver fibrosis is the main histopathologic manifestations of NAFLD. However, whether concomitant NAFLD influence…
View article: Association between neutrophil-lymphocyte ratio and female breast cancer: an observational study from NHANES 2001-2018 with external validation
Association between neutrophil-lymphocyte ratio and female breast cancer: an observational study from NHANES 2001-2018 with external validation Open
Background In the 21st century, breast cancer is the most frequent malignant tumor threatening women’s health. Previous research has confirmed that inflammatory response processes play key roles in tumor occurrence, development, and metast…
View article: Unraveling molecular characteristics and functional exploration of panoptosis for prognosis stratification in lung adenocarcinoma: a tumor marker prognostic study
Unraveling molecular characteristics and functional exploration of panoptosis for prognosis stratification in lung adenocarcinoma: a tumor marker prognostic study Open
Background: As a unique cell death modality mediated by multifaceted PANoptosome complexes, PANoptosis plays a crucial role in the development, invasion, and drug resistance of cancers. However, there is a lack of mechanisms for the PANopt…
View article: Food-derived bioactive peptides as emerging therapeutic agents: Unlocking novel strategies for colorectal cancer treatment
Food-derived bioactive peptides as emerging therapeutic agents: Unlocking novel strategies for colorectal cancer treatment Open
Colorectal cancer (CRC) ranks as the third most common cancer globally, with 1.9 million newly diagnosed cases annually and nearly 935,000 deaths, posing substantial healthcare challenges worldwide. Food-derived bioactive peptides (FDBPs) …
View article: Multi‐Omics Analysis Reveals Causal Relationships and Potential Mediators Between Dietary Preferences and Risk of <scp>NAFLD</scp>
Multi‐Omics Analysis Reveals Causal Relationships and Potential Mediators Between Dietary Preferences and Risk of <span>NAFLD</span> Open
Non‐alcoholic fatty liver disease (NAFLD) is a prevalent condition closely associated with obesity and metabolic syndrome, with its global incidence on the rise. This study aims to explore the causal relationship between dietary preference…
View article: Role of Exosomes in Cardiovascular Disease: A Key Regulator of Intercellular Communication in Cardiomyocytes
Role of Exosomes in Cardiovascular Disease: A Key Regulator of Intercellular Communication in Cardiomyocytes Open
In the cardiovascular system, different types of cardiovascular cells can secrete specific exosomes and participate in the maintenance of cardiovascular function and the occurrence and development of diseases. Exosomes carry biologically a…
View article: Global Burden of Cardiovascular Disease Attributable to Sugar‐Sweetened Beverages in Middle‐Aged Adults: An Age‐Period‐Cohort Modelling Study
Global Burden of Cardiovascular Disease Attributable to Sugar‐Sweetened Beverages in Middle‐Aged Adults: An Age‐Period‐Cohort Modelling Study Open
Background Cardiovascular disease (CVD) presents a significant burden among middle‐aged adults (aged 35–64). Diet high in sugar‐sweetened beverages is a notable CVD risk factor. Methods Using Global Burden of Disease data from 1990 to 2019…
View article: Identification of tryptophan metabolism-related biomarkers for nonalcoholic fatty liver disease through network analysis
Identification of tryptophan metabolism-related biomarkers for nonalcoholic fatty liver disease through network analysis Open
Background Increasing evidence demonstrates that tryptophan metabolism is closely related to the development of nonalcoholic fatty liver disease (NAFLD). This study aimed to identify specific biomarkers of NAFLD associated with tryptophan …
View article: The role of metal ion metabolism in the pathogenesis of diabetes and associated complications
The role of metal ion metabolism in the pathogenesis of diabetes and associated complications Open
Diabetes is a growing health concern, accompanied by significant complications like cardiovascular disease, kidney disease, and retinopathy. Metal ions, including iron, zinc, and copper, play a crucial role in maintaining human health thro…
View article: Comprehensive exploration of programmed cell death landscape in lung adenocarcinoma combining multi-omic analysis and experimental verification
Comprehensive exploration of programmed cell death landscape in lung adenocarcinoma combining multi-omic analysis and experimental verification Open
View article: Does diabetes modify the triglyceride–glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants
Does diabetes modify the triglyceride–glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants Open
View article: Plant protein-derived anti-breast cancer peptides: sources, therapeutic approaches, mechanisms, and nanoparticle design
Plant protein-derived anti-breast cancer peptides: sources, therapeutic approaches, mechanisms, and nanoparticle design Open
Breast cancer causes the deaths of approximately 685,000 women annually, posing a severe threat to women’s health. Consequently, there is an urgent need for low-cost, low-toxicity and effective therapeutic methods to prevent or mitigate br…
View article: The association between diabetes mellitus and postoperative cognitive dysfunction: a systematic review and meta-analysis
The association between diabetes mellitus and postoperative cognitive dysfunction: a systematic review and meta-analysis Open
Background: Postoperative cognitive dysfunction (POCD) is a typical consequence following surgery, particularly in cardiac surgeries. Despite its high incidence, the underlying etiology remains unclear. While diabetes mellitus (DM) has bee…
View article: Global Burden of Early-Onset Ischemic Heart Disease, 1990 to 2019
Global Burden of Early-Onset Ischemic Heart Disease, 1990 to 2019 Open
View article: Association between influenza vaccination and prognosis in patients with ischemic heart disease: A systematic review and meta-analysis of randomized controlled trials
Association between influenza vaccination and prognosis in patients with ischemic heart disease: A systematic review and meta-analysis of randomized controlled trials Open
This study suggests high level of evidence that the use of influenza vaccine reduce the risk of major adverse cardiovascular events in patients with IHD.
View article: Anti-breast cancer effects of dairy protein active peptides, dairy products, and dairy protein-based nanoparticles
Anti-breast cancer effects of dairy protein active peptides, dairy products, and dairy protein-based nanoparticles Open
Breast cancer is the most frequently diagnosed and fatal cancer among women worldwide. Dairy protein-derived peptides and dairy products are important parts of the daily human diet and have shown promising activities in suppressing the pro…
View article: Associations of human blood metabolome with optic neurodegenerative diseases: a bi-directionally systematic mendelian randomization study
Associations of human blood metabolome with optic neurodegenerative diseases: a bi-directionally systematic mendelian randomization study Open
View article: Dapagliflozin Ameliorates Myocardial Ischemia/Reperfusion Injury by Modulating EGFR Signaling and Targeting NCOA4-mediated Ferritinophagy
Dapagliflozin Ameliorates Myocardial Ischemia/Reperfusion Injury by Modulating EGFR Signaling and Targeting NCOA4-mediated Ferritinophagy Open
SGLT2 inhibitor dapagliflozin (Dapa) has gained increasing attention in the treatment of myocardial ischemia-reperfusion injury (IRI). However, the mechanism of action of the cardiovascular benefits of Dapa is unclear. The present study ai…
View article: Mild therapeutic hypothermic protection activates the PI3K/AKT signaling pathway to inhibit TRPM7 and suppress ferroptosis induced by myocardial ischemia‑reperfusion injury
Mild therapeutic hypothermic protection activates the PI3K/AKT signaling pathway to inhibit TRPM7 and suppress ferroptosis induced by myocardial ischemia‑reperfusion injury Open
The present study aimed to investigate the role of PI3K-mediated ferroptosis signaling induced by mild therapeutic hypothermia (MTH), which was defined as a temperature of 34°C, in protecting against myocardial ischemia-reperfusion (I/R) i…
View article: SGLT2 inhibitors: a novel therapy for cognitive impairment via multifaceted effects on the nervous system
SGLT2 inhibitors: a novel therapy for cognitive impairment via multifaceted effects on the nervous system Open
The rising prevalence of diabetes mellitus has casted a spotlight on one of its significant sequelae: cognitive impairment. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, originally developed for diabetes management, are increasingly s…
View article: Mild therapeutic hypothermia upregulates the O-GlcNAcylation level of COX10 to alleviate mitochondrial damage induced by myocardial ischemia–reperfusion injury
Mild therapeutic hypothermia upregulates the O-GlcNAcylation level of COX10 to alleviate mitochondrial damage induced by myocardial ischemia–reperfusion injury Open
Objective Mild therapeutic hypothermia (MTH) is an important method for perioperative prevention and treatment of myocardial ischemia–reperfusion injury (MIRI). Modifying mitochondrial proteins after protein translation to regulate mitocho…
View article: Targeting dysregulated lipid metabolism for the treatment of Alzheimer's disease and Parkinson's disease: Current advancements and future prospects
Targeting dysregulated lipid metabolism for the treatment of Alzheimer's disease and Parkinson's disease: Current advancements and future prospects Open
Alzheimer's and Parkinson's diseases are two of the most frequent neurological diseases. The clinical features of AD are memory decline and cognitive dysfunction, while PD mainly manifests as motor dysfunction such as limb tremors, muscle …
View article: Effect of pre-acidification and whey proteins on low-fat Mozzarella cheese during storage: physicochemical, textural, and functional properties
Effect of pre-acidification and whey proteins on low-fat Mozzarella cheese during storage: physicochemical, textural, and functional properties Open
The aim of the current study was to explore the effect of pre-acidification and whey protein-based fat replacers (CH-4560 and YO-8075) on low-fat Mozzarella cheese (LFC). The color and browning, calcium, meltability, texutre and pizza bake…
View article: Effect of pre-acidification and whey proteins on low-fat Mozzarella cheese during storage: physicochemical, textural, and functional properties
Effect of pre-acidification and whey proteins on low-fat Mozzarella cheese during storage: physicochemical, textural, and functional properties Open
The aim of the current study was to explore the effect of pre-acidification and whey protein-based fat replacers (CH-4560 and YO-8075) on low-fat Mozzarella cheese (LFC). The color and browning, calcium, meltability, texutre and pizza bake…