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View article: Development and characterization of anti-G12V mutated K-Ras monoclonal antibodies using hybridoma technology
Development and characterization of anti-G12V mutated K-Ras monoclonal antibodies using hybridoma technology Open
Background. Kirsten rat sarcoma oncogene, KRAS, is a gene that encodes for K-Ras protein, a membrane-anchored protein which is involved in intracellular signal transduction. Cells harbouring KRAS mutations have been reported to progress to…
View article: Cytotoxic and apoptosis-inducing effects of wildtype and mutated <i>Hydra</i> actinoporin-like toxin 1 (HALT-1) on various cancer cell lines
Cytotoxic and apoptosis-inducing effects of wildtype and mutated <i>Hydra</i> actinoporin-like toxin 1 (HALT-1) on various cancer cell lines Open
Background Hydra actinoporin like toxin -1 (HALT-1), is a small 18.5 kDa pore forming toxin derived from Hydra magnipapillata which has been shown to elicit strong haemolytic and cytolytic activity when in contact with cell membranes. Due …
View article: In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant <i>KRAS</i> antigens
In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant <i>KRAS</i> antigens Open
Background Somatic point substitution mutations in the KRAS proto-oncogene primarily affect codons 12/13 where glycine is converted into other amino acids, and are highly prevalent in pancreatic, colorectal, and non-small cell lung cancers…