Delfina P. González
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View article: A yeast model reveals the SMAD3 nuclear import mechanism
A yeast model reveals the SMAD3 nuclear import mechanism Open
TGF-β signaling is important for patterning tissues during embryonic development and relies on the nuclear import of SMADs. Basal SMAD nuclear import mechanisms remain to be fully understood and could benefit from advances in our understan…
View article: Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling
Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling Open
Wnt signaling is essential for many aspects of embryonic development including the formation of the primary embryonic axis. In addition, excessive Wnt signaling drives multiple diseases including cancer, highlighting its importance for dis…
View article: Discovering the Function of Congenital Heart Disease Genes
Discovering the Function of Congenital Heart Disease Genes Open
Congenital heart disease (CHD) is the most common congenital birth defect, manifesting as any structural cardiac abnormality. Heterotaxy (HTX) is a related class of birth defects characterized by misorientation of the organs along the left…
View article: Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling
Kap-β2/Transportin mediates β-catenin nuclear transport in Wnt signaling Open
SUMMARY Wnt signaling is essential for many aspects of embryonic development including the formation of the primary embryonic axis. In addition, excessive Wnt signaling drives multiple diseases including cancer highlighting its importance …
View article: CBD-1 organizes two independent complexes required for eggshell vitelline layer formation and egg activation in C. elegans
CBD-1 organizes two independent complexes required for eggshell vitelline layer formation and egg activation in C. elegans Open
Metazoan eggs have a specialized coat of extracellular matrix that aids in sperm-egg recognition. The coat is rapidly remodeled after fertilization to prevent polyspermy and establish a more permanent barrier to protect the developing embr…
View article: CBD-1 scaffolds two independent complexes required for eggshell vitelline layer formation and egg activation in <i>C. elegans</i>
CBD-1 scaffolds two independent complexes required for eggshell vitelline layer formation and egg activation in <i>C. elegans</i> Open
Metazoan eggs have a specialized coat of extracellular matrix that aids in sperm-egg recognition. The coat is rapidly remodeled after fertilization to prevent polyspermy and establish a more permanent barrier to protect the developing embr…
View article: Optimized strategy for in vivo Cas9-activation in <i>Drosophila</i>
Optimized strategy for in vivo Cas9-activation in <i>Drosophila</i> Open
Significance Recently, a number of approaches have been developed to repurpose the CRISPR/Cas9 system as a sequence-specific transcriptional activator for gain-of-function experiments (CRISPR activators, or “CRISPRa”). While multiple CRISP…