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View article: Nationwide Trends in Arthroscopic Knee Surgery and ACL Reconstruction in Romania, 2017–2023: Insights from a Seven-Year Health System Analysis
Nationwide Trends in Arthroscopic Knee Surgery and ACL Reconstruction in Romania, 2017–2023: Insights from a Seven-Year Health System Analysis Open
Arthroscopic knee surgery represents a cornerstone of modern orthopedic practice, yet nationwide data from Eastern Europe remain scarce. This study provides the first comprehensive assessment of arthroscopic knee procedures in Romania over…
View article: Akne vulgaris im Zusammenhang mit dem metabolischen Syndrom: Eine Serie von drei Fällen, die pathophysiologische Zusammenhänge und therapeutische Herausforderungen hervorhebt
Akne vulgaris im Zusammenhang mit dem metabolischen Syndrom: Eine Serie von drei Fällen, die pathophysiologische Zusammenhänge und therapeutische Herausforderungen hervorhebt Open
Hintergrund und klinische Bedeutung: Akne vulgaris ist eine häufige entzündliche Hauterkrankung, die klassischerweise mit einer Überproduktion von Talg, follikulärer Hyperkeratinisierung und der Proliferation von Cutibacterium acnes in Ver…
View article: Bibliometric Mapping of Soil Chemicalization and Fertilizer Research: Environmental and Computational Insights
Bibliometric Mapping of Soil Chemicalization and Fertilizer Research: Environmental and Computational Insights Open
Soil chemicalization, involving the use of synthetic chemicals like fertilizers, pesticides, and herbicides, has been crucial in modern agriculture but has raised concerns about soil degradation, environmental pollution, and long-term sust…
View article: Exploratory Analysis of Phenolic Profiles and Antioxidant Capacity in Selected Romanian Monofloral Honeys: Influence of Botanical Origin and Acquisition Source
Exploratory Analysis of Phenolic Profiles and Antioxidant Capacity in Selected Romanian Monofloral Honeys: Influence of Botanical Origin and Acquisition Source Open
This exploratory study assessed the influence of botanical origin and acquisition source on the phenolic profile and antioxidant properties of selected Romanian monofloral honeys. Eight samples were analyzed, representing five floral types…
View article: Healthcare Waste Toxicity: From Human Exposure to Toxic Mechanisms and Management Strategies
Healthcare Waste Toxicity: From Human Exposure to Toxic Mechanisms and Management Strategies Open
Healthcare waste (HCW) represents a growing yet frequently underestimated threat to public health, due to its complex toxicological profile. Exposure to HCW has been associated with a broad spectrum of adverse effects, including infections…
View article: Tracing Five Decades of Psoriasis Pharmacotherapy: A Large-Scale Bibliometric Investigation with AI-Guided Terminology Normalization
Tracing Five Decades of Psoriasis Pharmacotherapy: A Large-Scale Bibliometric Investigation with AI-Guided Terminology Normalization Open
Background/Objectives: Large-scale bibliometric assessments of psoriasis pharmacotherapy research remain limited despite significant research output in this rapidly evolving field. This study aimed to map the evolution of systemic psoriasi…
View article: Nationwide Epidemiology of Hospitalized Acute ACL Ruptures in Romania: A 7-Year Analysis (2017–2023)
Nationwide Epidemiology of Hospitalized Acute ACL Ruptures in Romania: A 7-Year Analysis (2017–2023) Open
Background and Objectives: Anterior cruciate ligament (ACL) rupture is one of the most frequent and debilitating knee injuries, especially among young, physically active individuals. While extensively studied in Western countries, large-sc…
View article: Cardiovascular Diseases: From Basic Research to Clinical Application
Cardiovascular Diseases: From Basic Research to Clinical Application Open
As we close the second edition of the Life Special Issue “Cardiovascular Diseases: From Basic Research to Clinical Application”, we would like to reflect on the progress made in understanding the molecular and physiological mechanisms unde…
View article: Real-World Evidence of Neuropsychiatric Adverse Reactions to Isotretinoin: Insights from EudraVigilance (2005–2025)
Real-World Evidence of Neuropsychiatric Adverse Reactions to Isotretinoin: Insights from EudraVigilance (2005–2025) Open
Background/Objectives: Isotretinoin is a highly effective therapy for severe acne, but its potential neuropsychiatric adverse reactions (NPsRs) have been controversial. This study evaluated EudraVigilance data from 2005 to 2025 to better u…
View article: Mapping Emerging Scientific Trends in Chronic Skin Disorders Using Machine Learning-Based Bibliometrics
Mapping Emerging Scientific Trends in Chronic Skin Disorders Using Machine Learning-Based Bibliometrics Open
Chronic dermatologic diseases are characterized by pathophysiologic complexity and the existence of many unmet patient management needs that can contribute to treatment failure, with poor adherence being a major issue. This study aims to i…
View article: Complete Revascularization in NSTE-ACS and Multivessel Disease: Clinical Outcomes and Prognostic Implications
Complete Revascularization in NSTE-ACS and Multivessel Disease: Clinical Outcomes and Prognostic Implications Open
Non-ST-segment-elevation acute coronary syndrome (NSTE-ACS) often coexists with multivessel coronary artery disease (MVD), complicating treatment decisions. Current guidelines suggest complete revascularization (CR), yet robust evidence in…
View article: Acne Vulgaris Associated with Metabolic Syndrome: A Three-Case Series Highlighting Pathophysiological Links and Therapeutic Challenges
Acne Vulgaris Associated with Metabolic Syndrome: A Three-Case Series Highlighting Pathophysiological Links and Therapeutic Challenges Open
Background and Clinical Significance: As a common inflammatory skin disorder, acne vulgaris is classically associated with sebum overproduction, follicular hyper keratinization, and Cutibacterium acnes proliferation. Emerging evidence sugg…
View article: Risk Stratification in Acute Coronary Syndromes: The Systemic Immune-Inflammation Index as Prognostic Marker
Risk Stratification in Acute Coronary Syndromes: The Systemic Immune-Inflammation Index as Prognostic Marker Open
Background/Objectives: Inflammation plays a key role in acute coronary syndromes (ACS). The systemic immune-inflammation index (SII), which integrates immune and inflammatory markers, may serve as a valuable prognostic tool. This study aim…
View article: Beyond Bone Mineral Density: Real-World Fracture Risk Profiles and Therapeutic Gaps in Postmenopausal Osteoporosis
Beyond Bone Mineral Density: Real-World Fracture Risk Profiles and Therapeutic Gaps in Postmenopausal Osteoporosis Open
Background/Objectives: Osteoporosis remains a leading cause of morbidity in postmenopausal women, yet many high-risk individuals remain undiagnosed or untreated. This study aimed to assess the prevalence of osteoporosis and osteopenia, tre…
View article: Multifactorial Refractory Acne in Women: Insights from a Case Series Involving Hormonal-, Metabolic-, and Corticosteroid-Related Triggers
Multifactorial Refractory Acne in Women: Insights from a Case Series Involving Hormonal-, Metabolic-, and Corticosteroid-Related Triggers Open
Acne vulgaris is a multifactorial inflammatory skin disorder that significantly impairs quality of life and may signal underlying systemic dysfunction, particularly in adult women with treatment-resistant or atypical presentations. This ca…
View article: Use of Botanical Supplements Among Romanian Individuals with Diabetes: Results from an Online Study on Prevalence, Practices, and Glycemic Control
Use of Botanical Supplements Among Romanian Individuals with Diabetes: Results from an Online Study on Prevalence, Practices, and Glycemic Control Open
Plant supplements are frequently used by diabetes mellitus (DM) patients in the management of their disease. Background/Objectives: The present study aimed to identify the prevalence of plant supplement use in DM patients from Romania and …
View article: Computational Evaluation and Multi-Criteria Optimization of Natural Compound Analogs Targeting SARS-CoV-2 Proteases
Computational Evaluation and Multi-Criteria Optimization of Natural Compound Analogs Targeting SARS-CoV-2 Proteases Open
The global impact of the COVID-19 crisis has underscored the need for novel therapeutic candidates capable of efficiently targeting essential viral proteins. Existing therapeutic strategies continue to encounter limitations such as reduced…
View article: Mapping the Global Research on Drug–Drug Interactions: A Multidecadal Evolution Through AI-Driven Terminology Standardization
Mapping the Global Research on Drug–Drug Interactions: A Multidecadal Evolution Through AI-Driven Terminology Standardization Open
The significant burden of polypharmacy in clinical settings contrasts sharply with the narrow research focus on drug–drug interactions (DDIs), revealing an important gap in understanding the complexity of real-world multi-drug regimens. Th…
View article: Physicochemical and Sensory Evaluation of Romanian Monofloral Honeys from Different Supply Chains
Physicochemical and Sensory Evaluation of Romanian Monofloral Honeys from Different Supply Chains Open
Honey quality and authenticity are influenced by floral origin, processing, and storage, with implications for composition and sensory appeal. This study offers a comparative assessment of eight monofloral honey samples, representing five …
View article: Functional Burden and Quality of Life in Hip and Knee Osteoarthritis: A Cross-Sectional Study
Functional Burden and Quality of Life in Hip and Knee Osteoarthritis: A Cross-Sectional Study Open
Background and Objectives: Osteoarthritis, the most common degenerative joint disease, causes pain, decreased mobility, and functional disability, having a significant impact on patients’ quality of life. This study aimed to evaluate the i…
View article: Obesity, Dietary Patterns, and Cardiovascular Disease: A Narrative Review of Metabolic and Molecular Pathways
Obesity, Dietary Patterns, and Cardiovascular Disease: A Narrative Review of Metabolic and Molecular Pathways Open
Cardiovascular diseases (CVDs) remain the leading global cause of death, with obesity acting as a significant contributing factor through mechanisms such as chronic inflammation, insulin resistance, and endothelial dysfunction. Molecular p…
View article: Comparative Pharmacovigilance Analysis of Approved and Repurposed Antivirals for COVID-19: Insights from EudraVigilance Data
Comparative Pharmacovigilance Analysis of Approved and Repurposed Antivirals for COVID-19: Insights from EudraVigilance Data Open
Background/Objectives: During the COVID-19 pandemic, several antivirals were approved or repurposed, but their safety profiles have not been fully compared. Pharmacovigilance data help clarify how these drugs perform in real-world use. Met…
View article: Challenging the One-Size-Fits-All Approach in Rheumatoid Arthritis Management by Addressing Serostatus-Driven Differences
Challenging the One-Size-Fits-All Approach in Rheumatoid Arthritis Management by Addressing Serostatus-Driven Differences Open
International rheumatoid arthritis (RA) guidelines do not differentiate treatment strategies based on serostatus, despite distinct disease differences between seronegative and seropositive patients. These groups vary in cellular abnormalit…
View article: Unraveling the Scientific Landscape of Osteoarthritis: Dynamics of Publications over Five Decades
Unraveling the Scientific Landscape of Osteoarthritis: Dynamics of Publications over Five Decades Open
Osteoarthritis is a disabling condition with highly complex overall management and persistent shortcomings, contributing significantly to the global disease burden. Although research in the field has grown considerably in recent years alon…
View article: Bibliometric Analysis of Medical Waste Research Using Python-Driven Algorithm
Bibliometric Analysis of Medical Waste Research Using Python-Driven Algorithm Open
The management of medical waste (MW) is a critical global challenge, contributing to toxic effects on humans, environmental degradation, and economic burdens. Despite advancements, gaps remain in adopting sustainable waste disposal practic…
View article: Predictors of Cognitive Decline in Alzheimer’s Disease: A Longitudinal Bayesian Analysis
Predictors of Cognitive Decline in Alzheimer’s Disease: A Longitudinal Bayesian Analysis Open
Background and Objectives: Alzheimer’s disease (AD) is a progressive neurodegenerative condition that significantly affects cognitive, emotional, and functional abilities in older adults. This study aimed to explore how demographic, clinic…
View article: The Impact of Hepatitis B and/or C on Liver Function and on the Response to Antiretroviral Therapy in HIV-Infected Patients: A Romanian Cohort Study
The Impact of Hepatitis B and/or C on Liver Function and on the Response to Antiretroviral Therapy in HIV-Infected Patients: A Romanian Cohort Study Open
Background: Hepatitis B (HBV) and C (HCV) virus coinfections remain major contributors to liver-related morbidity and mortality among people living with HIV (PLWH). This study aimed to assess the prevalence of HBV and/or HCV coinfections i…
View article: SUSPECTED ADVERSE DRUG REACTIONSTO FAVIPIRAVIR: INSIGHTS FROM EUDRAVIGILANCEREPORTS
SUSPECTED ADVERSE DRUG REACTIONSTO FAVIPIRAVIR: INSIGHTS FROM EUDRAVIGILANCEREPORTS Open
View article: Evaluation of the Alkaloids as Inhibitors of Human Acetylcholinesterase by Molecular Docking and ADME Prediction
Evaluation of the Alkaloids as Inhibitors of Human Acetylcholinesterase by Molecular Docking and ADME Prediction Open
These alkaloid derivatives warrant further investigation as potential acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
View article: Integrating Clinimetric and Psychometric Approaches in Enhancing Osteoarthritis Care
Integrating Clinimetric and Psychometric Approaches in Enhancing Osteoarthritis Care Open
Osteoarthritis (OA) is a degenerative joint disease that is typically associated with weight-bearing joints, such as the hips and knees, and is defined by the progressive deterioration of cartilage. The effective treatment of OA is conting…