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View article: A COVID–19-járvánnyal kapcsolatos tévhitek összefüggése a mentális egészséggel és az életminőséggel rekreációs e-sportolók körében
A COVID–19-járvánnyal kapcsolatos tévhitek összefüggése a mentális egészséggel és az életminőséggel rekreációs e-sportolók körében Open
Bevezetés: A COVID–19- (koronavírus-betegség 2019) világjárvány alapjaiban változtatta meg az emberek mindennapjait. A pandémiával kapcsolatos tévhitekkel foglalkozó intenzív kutatások ellenére a tévhitek és a mentális egészség (depresszió…
View article: Internet use May be associated with the severity of headache in migraine patients: results from a Hungarian tertiary headache center
Internet use May be associated with the severity of headache in migraine patients: results from a Hungarian tertiary headache center Open
View article: Opioid Utilisation in Hungary: National and Regional Analysis in Ambulatory and Hospital Care Sector
Opioid Utilisation in Hungary: National and Regional Analysis in Ambulatory and Hospital Care Sector Open
Background/Objectives: Opioid consumption analysis in Hungary, particularly through ambulatory and hospital sales data, including regional information, is lacking. This study examines opioid use in both sectors, explores regional variation…
View article: Gyógyszerrezisztens epilepsziás betegek pszichológiai vizsgálata: affektív tényezők és társas támogatás
Gyógyszerrezisztens epilepsziás betegek pszichológiai vizsgálata: affektív tényezők és társas támogatás Open
Bevezetés: Az epilepszia krónikus agyi betegség, amelynek kezelése elsősorban antiepileptikus gyógyszerekkel történik. Célkitűzés: Vizsgálatunk célja a gyógyszerrezisztens epilepsziás páciensek társas támogatásának feltérképezése, illetve …
View article: Profil Pengetahuan dan Faktor Risiko terkait Dispepsia Pada Mahasiswa Fakultas Non Kesehatan serta Ketepatan Tindakan Penanganannya
Profil Pengetahuan dan Faktor Risiko terkait Dispepsia Pada Mahasiswa Fakultas Non Kesehatan serta Ketepatan Tindakan Penanganannya Open
Dispepsia merupakan salah satu gangguan pencernaan dengan gejala, seperti nyeri atau rasa tidak nyaman pada perut, mual, muntah, perut kembung, sendawa, ataupun perut terasa kenyang secara berlebihan. Dispepsia merupakan salah satu problem…
View article: DESMOPLAKIN ASSOCIATED NON DILATED LEFT VENTRICULAR CARDIOMYOPATHY TREATED WITH ANAKINRA
DESMOPLAKIN ASSOCIATED NON DILATED LEFT VENTRICULAR CARDIOMYOPATHY TREATED WITH ANAKINRA Open
A 24 year old female patient experienced,from 2010 to November 2023,12 myocarditis–like episodes, often related to emotional stress, characterized by chest pain,increased markers of myocardial necrosis, normal C–reactive Protein values,nor…
View article: From CGRP to PACAP, VIP, and Beyond: Unraveling the Next Chapters in Migraine Treatment
From CGRP to PACAP, VIP, and Beyond: Unraveling the Next Chapters in Migraine Treatment Open
Migraine is a neurovascular disorder that can be debilitating for individuals and society. Current research focuses on finding effective analgesics and management strategies for migraines by targeting specific receptors and neuropeptides. …
View article: From CGRP to PACAP: Unraveling the Next Chapter in Migraine Treatment
From CGRP to PACAP: Unraveling the Next Chapter in Migraine Treatment Open
Migraine is a neurovascular disorder that can be debilitating for individuals and society. Current research focuses on finding effective analgesics and management strategies for migraines by targeting specific receptors and neuropeptides. …
View article: From CGRP to PACAP: Unraveling the Next Chapter in Migraine Treatment
From CGRP to PACAP: Unraveling the Next Chapter in Migraine Treatment Open
Migraine is a neurovascular disorder that can be debilitating for individuals and society. Current research focuses on finding effective analgesics and management strategies for migraines by targeting specific receptors and neuropeptides. …
View article: The pharmacotherapeutic management of episodic and chronic migraine with gepants
The pharmacotherapeutic management of episodic and chronic migraine with gepants Open
Whether gepants will be real game changers in the acute treatment of migraine compared to triptans and ditans or in the prophylactic therapy compared to standard-of-care preventive drugs or CGRP-targeting monoclonal antibodies cannot be an…
View article: Cluster headache and kynurenines
Cluster headache and kynurenines Open
View article: Chronic Migraine as a Primary Chronic Pain Syndrome and Recommended Prophylactic Therapeutic Options: A Literature Review
Chronic Migraine as a Primary Chronic Pain Syndrome and Recommended Prophylactic Therapeutic Options: A Literature Review Open
Chronic pain conditions have a high socio-economic impact and represent a burden for patients, and their management is a challenge for healthcare professionals. Chronic migraine is one of the chronic primary headache disorders, which belon…
View article: Exploring Novel Therapeutic Targets in the Common Pathogenic Factors in Migraine and Neuropathic Pain
Exploring Novel Therapeutic Targets in the Common Pathogenic Factors in Migraine and Neuropathic Pain Open
Migraine and neuropathic pain (NP) are both painful, disabling, chronic conditions which exhibit some symptom similarities and are thus considered to share a common etiology. The calcitonin gene-related peptide (CGRP) has gained credit as …
View article: Cluster headache and kynurenines
Cluster headache and kynurenines Open
Background: The glutamatergic neurotransmission has important role in the pathomechanism of primary headache disorders. The kynurenine metabolites derived from catabolism of tryptophan (Trp) have significant involvement not only in glutama…
View article: Exploring Novel Therapeutic Targets in the Common Pathogenic Factors in Migraine and Neuropathic Pain
Exploring Novel Therapeutic Targets in the Common Pathogenic Factors in Migraine and Neuropathic Pain Open
Migraine and neuropathic pain (NP) are evocative of painful, disabling, chronic conditions which exhibit resembling symptoms and thus considered to share a common etiology. Calcitonin gene-related peptide (CGRP) has gained credit as a targ…
View article: Fejfájás • Headache
Fejfájás • Headache Open
A fejfájásbetegségek gyakoriak, az életminőséget jelentősen rontják, az egészségkárosodásban eltöltött életéveket megnövelik, és mindezek alapján jelentős terhet rónak a társadalomra.Kihívást jelentenek a pácienseket ellátó egészségügyi sz…
View article: Fejfájásregiszter kialakításával szerzett szegedi tapasztalataink migrénes betegek vonatkozásában
Fejfájásregiszter kialakításával szerzett szegedi tapasztalataink migrénes betegek vonatkozásában Open
Háttér és cél – A betegregiszterek alkalmazása elengedhetetlen a klinikai kutatásban és az orvosi gyakorlatban. A fejfájás, azon belül a migrén az egyik leggyakoribb panasz, ami jelentősen rontja a betegek életminőségét, és magas a társada…
View article: Szumatriptán–naproxén-nátrium fix dózisú kombinációja a migrén akut kezelésében – irodalmi áttekintés
Szumatriptán–naproxén-nátrium fix dózisú kombinációja a migrén akut kezelésében – irodalmi áttekintés Open
A migrén az elsődleges fejfájásbetegségek közé tartozó gyakori megbetegedés, ami nagymértékben károsítja az egyén életminőségét. Gyógyszeres kezelésében akut és megelőző terápiákat különítünk el. Az Európai Fejfájás Társaság és az Európai …
View article: Trends in opioid utilization in Hungary, 2006–2020: A nationwide retrospective study with multiple metrics
Trends in opioid utilization in Hungary, 2006–2020: A nationwide retrospective study with multiple metrics Open
Background Opioid use is well documented in several countries: some countries struggle with overuse, whereas others have almost no access to opioids. For Europe, limited data are available. This study analysed Hungarian opioid utilization …
View article: CGRP and CGRP-Receptor as Targets of Migraine Therapy: BrainPrize-2021
CGRP and CGRP-Receptor as Targets of Migraine Therapy: BrainPrize-2021 Open
Background : Migraine is a highly prevalent primary headache with an unclear pathomechanism. During the last 40 years, numerous hypotheses have arisen; among them, the theory of the trigeminovascular system is the primary one. It serves as…
View article: Chronic Pain Hurts the Brain: The Pain Physician’s Perspective
Chronic Pain Hurts the Brain: The Pain Physician’s Perspective Open
View article: Therapeutic Approaches for Peripheral and Central Neuropathic Pain
Therapeutic Approaches for Peripheral and Central Neuropathic Pain Open
Neuropathic pain is a chronic secondary pain condition, which is a consequence of peripheral or central nervous (somatosensory) system lesions or diseases. It is a devastating condition, which affects around 7% of the general population. N…
View article: Are Migraine With and Without Aura Really Different Entities?
Are Migraine With and Without Aura Really Different Entities? Open
Background: Migraine research is booming with the rapidly developing neuroimaging tools. Structural and functional alterations of the migrainous brain were detected with MRI. The outcome of a research study largely depends on the wo…
View article: Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura
Altered Resting State Functional Activity and Microstructure of the White Matter in Migraine With Aura Open
Introduction: Brain structure and function were reported to be altered in migraine. Importantly our earlier results showed that white matter diffusion abnormalities and resting state functional activity were affected differently in …
View article: Therapeutic strategies that act on the peripheral nervous system in primary headache disorders
Therapeutic strategies that act on the peripheral nervous system in primary headache disorders Open
Introduction: Acute and preventive treatment of primary headache disorders is not completely resolved with regard to efficacy, safety, and tolerability. Hence, peripheral and central neuromodulation can provide therapeutic alternati…
View article: A case of Infective Endocarditis due to Salmonella enterica phagetype 35. First report.
A case of Infective Endocarditis due to Salmonella enterica phagetype 35. First report. Open
Infective Endocarditis (IE) has high morbidity and mortality. To date, in addition to classic Gram-positive pathogens were isolated exigent Gram negative bacteria responsible of endocarditis as A. baumannii, A. lwoffii, C. burnetii, Barton…
View article: Evidence for Plastic Processes in Migraine with Aura: A Diffusion Weighted MRI Study
Evidence for Plastic Processes in Migraine with Aura: A Diffusion Weighted MRI Study Open
Background: Formerly white matter abnormalities in a mixed group of migraine patients with and without aura were shown. Here, we aimed to explore white matter alterations in a homogeneous group of migraineurs with aura and to deline…
View article: <i>Campylobacter:</i> from microbiology to prevention.
<i>Campylobacter:</i> from microbiology to prevention. Open
In last years, Campylobacter spp has become one of the most important foodborne pathogens even in high-income countries. Particularly, in Europe, Campylobacteriosis is, since 2005, the foodborne disease most frequently notified and the sec…
View article: Macro- and microstructural alterations of the subcortical structures in episodic cluster headache
Macro- and microstructural alterations of the subcortical structures in episodic cluster headache Open
Background Previous functional and structural imaging studies have revealed that subcortical structures play a key a role in pain processing. The recurring painful episodes might trigger maladaptive plasticity or alternatively degenerative…
View article: Kynurenines and PACAP in Migraine: Medicinal Chemistry and Pathogenetic Aspects
Kynurenines and PACAP in Migraine: Medicinal Chemistry and Pathogenetic Aspects Open
L-kynurenine, kynurenic acid, and pituitary adenylate cyclase-activating polypeptide may have fundamental roles in the initiation of migraine headache attacks.