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View article: Structural Domain Analysis of Heparin and Heparan Sulfate Combined With Label-Free Quantitative Proteomics to Elucidate Their Functional Diversity in Liver Cancer and APAP-Induced Liver Injury
Structural Domain Analysis of Heparin and Heparan Sulfate Combined With Label-Free Quantitative Proteomics to Elucidate Their Functional Diversity in Liver Cancer and APAP-Induced Liver Injury Open
The precise structure of glycosaminoglycans is critical for their bioactivity and the development of glycopharmaceuticals. Herein, cellular and animal experiments were conducted to assess the differences in the activities of heparin (HP) a…
View article: Low molecular weight heparin promotes the PPAR pathway by protecting the glycocalyx of cells to delay the progression of diabetic nephropathy
Low molecular weight heparin promotes the PPAR pathway by protecting the glycocalyx of cells to delay the progression of diabetic nephropathy Open
View article: Bacterial pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin in a murine model
Bacterial pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin in a murine model Open
Primary Staphylococcus aureus pneumonia causes pulmonary epithelial heparan sulfate (HS) shedding into the airspace. These highly sulfated HS fragments do not alter bacterial growth or transcription, but directly bind with host antimicrobi…
View article: The Sea Cucumber <i>Thyonella gemmata</i> Contains a Low Anticoagulant Sulfated Fucan with High Anti-SARS-CoV-2 Actions against Wild-Type and Delta Variants
The Sea Cucumber <i>Thyonella gemmata</i> Contains a Low Anticoagulant Sulfated Fucan with High Anti-SARS-CoV-2 Actions against Wild-Type and Delta Variants Open
In this work, we isolated two new sulfated glycans from the body wall of the sea cucumber Thyonella gemmata: one fucosylated chondroitin sulfate (TgFucCS) (17.5 ± 3.5% kDa) and one sulfated fucan (TgSF) (383.3 ± 2.1% kDa). NMR resul…
View article: SPR Sensor-Based Analysis of the Inhibition of Marine Sulfated Glycans on Interactions between Monkeypox Virus Proteins and Glycosaminoglycans
SPR Sensor-Based Analysis of the Inhibition of Marine Sulfated Glycans on Interactions between Monkeypox Virus Proteins and Glycosaminoglycans Open
Sulfated glycans from marine organisms are excellent sources of naturally occurring glycosaminoglycan (GAG) mimetics that demonstrate therapeutic activities, such as antiviral/microbial infection, anticoagulant, anticancer, and anti-inflam…
View article: Interactions of heparin with key glycoproteins of human respiratory syncytial virus
Interactions of heparin with key glycoproteins of human respiratory syncytial virus Open
Introduction: The unexpected surge of respiratory syncytial virus (RSV) cases following pandemic phase of COVID-19 has drawn much public attention. Drawing on the latest antiviral research, revisiting this heightened annual outbreak of res…
View article: Structure, anti-SARS-CoV-2, and anticoagulant effects of two sulfated galactans from the red alga Botryocladia occidentalis
Structure, anti-SARS-CoV-2, and anticoagulant effects of two sulfated galactans from the red alga Botryocladia occidentalis Open
View article: Structural Characteristics of Heparin Binding to SARS-CoV-2 Spike Protein RBD of Omicron Sub-Lineages BA.2.12.1, BA.4 and BA.5
Structural Characteristics of Heparin Binding to SARS-CoV-2 Spike Protein RBD of Omicron Sub-Lineages BA.2.12.1, BA.4 and BA.5 Open
The now prevalent Omicron variant and its subvariants/sub-lineages have led to a significant increase in COVID-19 cases and raised serious concerns about increased risk of infectivity, immune evasion, and reinfection. Heparan sulfate (HS),…
View article: The influenza-injured lung microenvironment promotes MRSA virulence, contributing to severe secondary bacterial pneumonia
The influenza-injured lung microenvironment promotes MRSA virulence, contributing to severe secondary bacterial pneumonia Open
View article: Kinetic and Structural Aspects of Glycosaminoglycan–Monkeypox Virus Protein A29 Interactions Using Surface Plasmon Resonance
Kinetic and Structural Aspects of Glycosaminoglycan–Monkeypox Virus Protein A29 Interactions Using Surface Plasmon Resonance Open
Monkeypox virus (MPXV), a member of the Orthopoxvirus genus, has begun to spread into many countries worldwide. While the prevalence of monkeypox in Central and Western Africa is well-known, the recent rise in the number of cases spread th…
View article: Glycosaminoglycan-Protein Interactions and Their Roles in Human Disease
Glycosaminoglycan-Protein Interactions and Their Roles in Human Disease Open
Glycosaminoglycans (GAGs) are a family of linear and negatively charged polysaccharides that exist ubiquitously on the human cell surface as well as in the extracellular matrix. GAGs interact with a wide range of proteins, including protea…
View article: Discovery of exolytic heparinases and their catalytic mechanism and potential application
Discovery of exolytic heparinases and their catalytic mechanism and potential application Open
View article: Discovery of exolytic heparinases and their catalytic mechanism and potential application
Discovery of exolytic heparinases and their catalytic mechanism and potential application Open
The authors have withdrawn this preprint due to author disagreement.
View article: Discovery of exolytic heparinases and their catalytic mechanism and potential application
Discovery of exolytic heparinases and their catalytic mechanism and potential application Open
Heparinases are critical tools for the studies of highly heterogeneous heparin (HP)/heparan sulfate (HS). However, the exolytic heparinases urgently needed for the sequencing of HP/HS chains are seemingly inaccessible. Herein, a type of ex…