Delphi Chatterjee
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View article: Trial design of bacteriophage therapy for nontuberculous mycobacteria pulmonary disease in cystic fibrosis: The POSTSTAMP study
Trial design of bacteriophage therapy for nontuberculous mycobacteria pulmonary disease in cystic fibrosis: The POSTSTAMP study Open
Bacteriophages (phages) are viruses that selectively infect bacteria and have been utilized to treat Mycobacterium abscessus (Mab) with varying success. The POSTSTAMP study is an ongoing, multi-site phage therapy protocol for treatment-ref…
View article: Prospective Analysis of urINe LAM to Eliminate NTM Sputum Screening (PAINLESS) study: Rationale and trial design for testing urine lipoarabinomannan as a marker of NTM lung infection in cystic fibrosis
Prospective Analysis of urINe LAM to Eliminate NTM Sputum Screening (PAINLESS) study: Rationale and trial design for testing urine lipoarabinomannan as a marker of NTM lung infection in cystic fibrosis Open
Background Routine screening for nontuberculous mycobacterial (NTM) lung disease is dependent on sputum cultures. This is particularly challenging in the cystic fibrosis (CF) population due to reduced sputum production and low culture sens…
View article: Prospective Analysis of urINe LAM to Eliminate NTM Sputum Screening (PAINLESS) study: Rationale and trial design for testing urine lipoarabinomannan as a marker of NTM lung infection in cystic fibrosis
Prospective Analysis of urINe LAM to Eliminate NTM Sputum Screening (PAINLESS) study: Rationale and trial design for testing urine lipoarabinomannan as a marker of NTM lung infection in cystic fibrosis Open
Background Routine screening for nontuberculous mycobacterial (NTM) lung disease is dependent on sputum cultures. This is particularly challenging in the cystic fibrosis (CF) population due to reduced sputum production and low culture sens…
View article: Urine Lipoarabinomannan as a Biomarker for Mycobacterium tuberculosis and non-tuberculous mycobacterial infections v1
Urine Lipoarabinomannan as a Biomarker for Mycobacterium tuberculosis and non-tuberculous mycobacterial infections v1 Open
Lipoarabinomannan (LAM) is a unique cell wall component containing a fatty acid region with a large mannan core attached to poly-arabinan chains, sometimes followed by mannose capping in Actinomyces species. The hydrophobic region made of …
View article: Correction: Performance of novel antibodies for lipoarabinomannan to develop diagnostic tests for Mycobacterium tuberculosis
Correction: Performance of novel antibodies for lipoarabinomannan to develop diagnostic tests for Mycobacterium tuberculosis Open
[This corrects the article DOI: 10.1371/journal.pone.0274415.].
View article: Collected Thoughts on Mycobacterial Lipoarabinomannan, a Cell Envelope Lipoglycan
Collected Thoughts on Mycobacterial Lipoarabinomannan, a Cell Envelope Lipoglycan Open
The presence of lipoarabinomannan (LAM) in the Mycobacterium tuberculosis (Mtb) cell envelope was first reported close to 100 years ago. Since then, numerous studies have been dedicated to the isolation, purification, structural definition…
View article: Culture independent markers of nontuberculous mycobacterial (NTM) lung infection and disease in the cystic fibrosis airway
Culture independent markers of nontuberculous mycobacterial (NTM) lung infection and disease in the cystic fibrosis airway Open
View article: Overcome low levels of detection limit and choice of antibody affects detection of lipoarabinomannan in pediatric tuberculosis
Overcome low levels of detection limit and choice of antibody affects detection of lipoarabinomannan in pediatric tuberculosis Open
The World Health Organization (WHO) emphasizes that tuberculosis (TB) in children and adolescents is often overlooked by healthcare providers and difficult to diagnose. As childhood TB cases rise, finding a diagnostic high in sensitivity a…
View article: Performance of novel antibodies for lipoarabinomannan to develop diagnostic tests for Mycobacterium tuberculosis
Performance of novel antibodies for lipoarabinomannan to develop diagnostic tests for Mycobacterium tuberculosis Open
Lipoarabinomannan (LAM), a component of the Mycobacterium tuberculosis (MTB) cell wall, is detectable in the urine of MTB infected patients with active tuberculosis (TB). LAM-specific antibodies (Igs) have been developed by a variety of tr…
View article: Monoclonal antibodies to lipoarabinomannan/arabinomannan – characteristics and implications for tuberculosis research and diagnostics
Monoclonal antibodies to lipoarabinomannan/arabinomannan – characteristics and implications for tuberculosis research and diagnostics Open
View article: Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection
Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection Open
View article: Performance of novel antibodies for lipoarabinomannan to develop diagnostic tests for <i>Mycobacterium tuberculosis</i>
Performance of novel antibodies for lipoarabinomannan to develop diagnostic tests for <i>Mycobacterium tuberculosis</i> Open
Lipoarabinomannan (LAM), a component of the Mycobacterium tuberculosis (MTB) cell wall, is detectable in the urine of MTB infected patients with active tuberculosis (TB). LAM-specific antibodies (Igs) have been developed by a variety of tr…
View article: Simple manipulation of enzyme-linked immunosorbent assay (ELISA) using an automated microfluidic interface
Simple manipulation of enzyme-linked immunosorbent assay (ELISA) using an automated microfluidic interface Open
ELISA on microfluidic interface device for lipoarabinomannan.
View article: Simple Manipulation of Enzyme-Linked Immunosorbent Assay (Elisa) Using an Automated Microfluidic Interface
Simple Manipulation of Enzyme-Linked Immunosorbent Assay (Elisa) Using an Automated Microfluidic Interface Open
View article: Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes
Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes Open
View article: Structural implications of lipoarabinomannan glycans from global clinical isolates in diagnosis of Mycobacterium tuberculosis infection
Structural implications of lipoarabinomannan glycans from global clinical isolates in diagnosis of Mycobacterium tuberculosis infection Open
View article: Immobilization of Proteinase K for urine pretreatment to improve diagnostic accuracy of active tuberculosis
Immobilization of Proteinase K for urine pretreatment to improve diagnostic accuracy of active tuberculosis Open
The World Health Organization (WHO) calls for the development of a rapid, biomarker-based, non-sputum test capable of detecting all forms of tuberculosis (TB) at the point-of-care to enable immediate treatment initiation. Lipoarabinomannan…
View article: Urine lipoarabinomannan in HIV uninfected, smear negative, symptomatic TB patients: effective sample pretreatment for a sensitive immunoassay and mass spectrometry
Urine lipoarabinomannan in HIV uninfected, smear negative, symptomatic TB patients: effective sample pretreatment for a sensitive immunoassay and mass spectrometry Open
View article: Urine lipoarabinomannan as a marker for low-risk of NTM infection in the CF airway
Urine lipoarabinomannan as a marker for low-risk of NTM infection in the CF airway Open
These findings support the conclusion that urine LAM related to NTM infection may be a useful screening test to determine patients at low risk for having a positive NTM sputum culture, as part of a lifetime screening strategy in the CF pop…
View article: Altered composition and functional profile of high-density lipoprotein in leprosy patients
Altered composition and functional profile of high-density lipoprotein in leprosy patients Open
The changes in host lipid metabolism during leprosy have been correlated to fatty acid alterations in serum and with high-density lipoprotein (HDL) dysfunctionality. This is most evident in multibacillary leprosy patients (Mb), who present…
View article: Comparative Structural Study of Terminal Ends of Lipoarabinomannan from Mice Infected Lung Tissues and Urine of a Tuberculosis Positive Patient
Comparative Structural Study of Terminal Ends of Lipoarabinomannan from Mice Infected Lung Tissues and Urine of a Tuberculosis Positive Patient Open
Mycobacterium tuberculosis lipoarabinomannan (LAM) is a biomarker for active tuberculosis (TB) disease. The presence of LAM in the urine of TB patients, whether HIV positive or negative, has been validated by a gas chromatography/ma…
View article: Detection of the tuberculosis biomarker mannose-capped lipoarabinomannan in human serum: Impact of sample pretreatment with perchloric acid
Detection of the tuberculosis biomarker mannose-capped lipoarabinomannan in human serum: Impact of sample pretreatment with perchloric acid Open
The development of an accurate and rapid diagnostic test for tuberculosis (TB) to use at point of need is vital to efforts aimed at reducing the global burden from this disease. This paper builds on our previous studies of mannose-capped l…
View article: Structural determinants in a glucose-containing lipopolysaccharide from Mycobacterium tuberculosis critical for inducing a subset of protective T cells
Structural determinants in a glucose-containing lipopolysaccharide from Mycobacterium tuberculosis critical for inducing a subset of protective T cells Open
View article: Characterization of the Antigenic Heterogeneity of Lipoarabinomannan, the Major Surface Glycolipid of <i>Mycobacterium tuberculosis</i>, and Complexity of Antibody Specificities toward This Antigen
Characterization of the Antigenic Heterogeneity of Lipoarabinomannan, the Major Surface Glycolipid of <i>Mycobacterium tuberculosis</i>, and Complexity of Antibody Specificities toward This Antigen Open
Lipoarabinomannan (LAM), the major antigenic glycolipid of Mycobacterium tuberculosis, is an important immunodiagnostic target for detecting tuberculosis (TB) infection in HIV-1–coinfected patients, and is believed to mediate a number of f…
View article: A Subset of Protective γ<sub>9</sub>δ<sub>2</sub>T Cells Is Activated by Novel Mycobacterial Glycolipid Components
A Subset of Protective γ<sub>9</sub>δ<sub>2</sub>T Cells Is Activated by Novel Mycobacterial Glycolipid Components Open
γ 9 δ 2 T cells provide a natural bridge between innate and adaptive immunity, rapidly and potently respond to pathogen infection in mucosal tissues, and are prominently induced by both tuberculosis (TB) infection and bacillus Calmette Gué…
View article: Estimation of D-Arabinose by Gas Chromatography/Mass Spectrometry as Surrogate for Mycobacterial Lipoarabinomannan in Human Urine
Estimation of D-Arabinose by Gas Chromatography/Mass Spectrometry as Surrogate for Mycobacterial Lipoarabinomannan in Human Urine Open
Globally, tuberculosis is slowly declining each year and it is estimated that 37 million lives were saved between 2000 and 2013 through effective diagnosis and treatment. Currently, diagnosis relies on demonstration of the bacteria, Mycoba…
View article: Tuberculosis in the African continent: A comprehensive review
Tuberculosis in the African continent: A comprehensive review Open
Tuberculosis continues to be a major global health problem, causing an estimated 8.8 million new cases and 1.45 million deaths annually. New drugs in the 1940s made it possible to beat the disease, and consequently, the number of cases red…
View article: Early Detection of Tuberculosis: An Emerging Diagnostic Using Surface-Enhanced Raman Scattering (SERS)
Early Detection of Tuberculosis: An Emerging Diagnostic Using Surface-Enhanced Raman Scattering (SERS) Open