Delphine Baetz
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View article: Extended Preservation of Heart Grafts: LYPS Solution Maintains Cardiac Function During 20-Hour Static Cold Storage
Extended Preservation of Heart Grafts: LYPS Solution Maintains Cardiac Function During 20-Hour Static Cold Storage Open
Heart transplantation is severely limited by the shortage of suitable donor grafts, partly due to myocardial vulnerability to ischemia–reperfusion injury and the lack of standardized preservation strategies. Current solutions only partiall…
View article: #452 Plasma extracellular cold-inducible RNA-binding protein (eCIRP) is associated with acute kidney injury in patients after cardiac arrest
#452 Plasma extracellular cold-inducible RNA-binding protein (eCIRP) is associated with acute kidney injury in patients after cardiac arrest Open
Background and Aims Acute kidney injury (AKI) is a predictor of mortality after a resuscitated cardiac arrest (CA). We aimed to evaluate plasma extracellular cold-induced RNA-binding protein (eCIRP), a pro-inflammatory alarmin released in …
View article: Cold-Inducible RNA-Binding Protein in Cardiac Arrest and Renal Ischemia-Reperfusion Injury
Cold-Inducible RNA-Binding Protein in Cardiac Arrest and Renal Ischemia-Reperfusion Injury Open
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View article: #337 Renal 3D photoacoustic imaging and contrast-enhanced ultrasound to assess oxygenation and perfusion and to predict fibrosis after ischemia-reperfusion
#337 Renal 3D photoacoustic imaging and contrast-enhanced ultrasound to assess oxygenation and perfusion and to predict fibrosis after ischemia-reperfusion Open
Background and Aims Renal 3D photo-acoustic imaging (3D-PAI) and contrast-enhanced ultrasound (CEUS) are promising tools in mice models to assess repeatedly and non-invasively renal ischemia-reperfusion (RIR) consequences and damages, or t…
View article: Kynurenic Acid: A Novel Player in Cardioprotection against Myocardial Ischemia/Reperfusion Injuries
Kynurenic Acid: A Novel Player in Cardioprotection against Myocardial Ischemia/Reperfusion Injuries Open
Background: Myocardial infarction is one of the leading causes of mortality worldwide; hence, there is an urgent need to discover novel cardioprotective strategies. Kynurenic acid (KYNA), a metabolite of the kynurenine pathway, has been pr…
View article: Heat Shock Protein 70 Is Involved in the Efficiency of Preconditioning with Cyclosporine A in Renal Ischemia Reperfusion Injury by Modulating Mitochondrial Functions
Heat Shock Protein 70 Is Involved in the Efficiency of Preconditioning with Cyclosporine A in Renal Ischemia Reperfusion Injury by Modulating Mitochondrial Functions Open
Cyclosporine A (CsA) preconditioning is known to target mitochondrial permeability transition pore and protect renal function after ischemia reperfusion (IR). The upregulation of heat-shock protein 70 (Hsp70) expression after CsA injection…
View article: Isolated Mitochondria State after Myocardial Ischemia-Reperfusion Injury and Cardioprotection: Analysis by Flow Cytometry
Isolated Mitochondria State after Myocardial Ischemia-Reperfusion Injury and Cardioprotection: Analysis by Flow Cytometry Open
Rationale: Mitochondria are key organelles involved in cell survival and death during the acute phenomena of myocardial ischemia-reperfusion (i.e., myocardial infarction). To investigate the functions of isolated mitochondria such as calci…
View article: Postconditioning by Delayed Administration of Ciclosporin A: Implication for Donation after Circulatory Death (DCD)
Postconditioning by Delayed Administration of Ciclosporin A: Implication for Donation after Circulatory Death (DCD) Open
Heart transplantation is facing a shortage of grafts. Donation after Circulatory Death (DCD) would constitute a new potential of available organs. In the present work, we aimed to evaluate whether Postconditioning (ischemic or with ciclosp…
View article: Mild Therapeutic Hypothermia Protects from Acute and Chronic Renal Ischemia-Reperfusion Injury in Mice by Mitigated Mitochondrial Dysfunction and Modulation of Local and Systemic Inflammation
Mild Therapeutic Hypothermia Protects from Acute and Chronic Renal Ischemia-Reperfusion Injury in Mice by Mitigated Mitochondrial Dysfunction and Modulation of Local and Systemic Inflammation Open
Renal ischemia-reperfusion (IR) injury can lead to acute kidney injury, increasing the risk of developing chronic kidney disease. We hypothesized that mild therapeutic hypothermia (mTH), 34 °C, applied during ischemia could protect the fun…
View article: Addendum: Gouriou et al. ANT2-Mediated ATP Import into Mitochondria Protects against Hypoxia Lethal Injury. Cells 2020, 9, 2542
Addendum: Gouriou et al. ANT2-Mediated ATP Import into Mitochondria Protects against Hypoxia Lethal Injury. Cells 2020, 9, 2542 Open
The authors and the Cells Editorial Office would like to add the section “Materials and Methods”, which was missing in the original version [...]
View article: DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries
DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries Open
Mitochondrial dynamics is a possible modulator of myocardial ischemia/reperfusion injuries (IRI). We previously reported that mice partially deficient in the fusion protein OPA1 exhibited higher IRI. Therefore, we investigated whether defi…
View article: Mechanisms of protection of mild therapeutic hypothermia during renal ischaemia-reperfusion in mice
Mechanisms of protection of mild therapeutic hypothermia during renal ischaemia-reperfusion in mice Open
View article: ANT2-Mediated ATP Import into Mitochondria Protects against Hypoxia Lethal Injury
ANT2-Mediated ATP Import into Mitochondria Protects against Hypoxia Lethal Injury Open
Following a prolonged exposure to hypoxia–reoxygenation, a partial disruption of the ER-mitochondria tethering by mitofusin 2 (MFN2) knock-down decreases the Ca2+ transfer between the two organelles limits mitochondrial Ca2+ overload and p…
View article: P0536HYPOTHERMIA DURING RENAL ISCHEMIA-REPERFUSION IN MICE: A PROTECTIVE EFFECT ON RENAL AND MITOCHONDRIAL FUNCTIONS
P0536HYPOTHERMIA DURING RENAL ISCHEMIA-REPERFUSION IN MICE: A PROTECTIVE EFFECT ON RENAL AND MITOCHONDRIAL FUNCTIONS Open
Background and Aims Renal ischemia reperfusion (RIR) can induce mitochondrial stress triggering cell death and eventually leading to acute kidney injury (AKI). It has been suggested that mild hypothermia could be protective in RIR without …
View article: P1681Daytime variation of infarct size in STEMI patients
P1681Daytime variation of infarct size in STEMI patients Open
Background: Limited studies have shown that statin therapy may be effective on clinical outcome in patients with coronary vasospastic angina (VSA).Its evidences have not accumulated enough.Purpose: We tried to assess the impact of statin t…
View article: Early kinetics of serum Interleukine-17A and infarct size in patients with reperfused acute ST-elevated myocardial infarction
Early kinetics of serum Interleukine-17A and infarct size in patients with reperfused acute ST-elevated myocardial infarction Open
Serum IL-17A level is significantly increased in patients at the early phase of acute MI compared to healthy controls. However, the level of IL-17A in the early hours after reperfusion does not correlate with IS.
View article: Dose and timing of injections for effective cyclosporine A pretreatment before renal ischemia reperfusion in mice
Dose and timing of injections for effective cyclosporine A pretreatment before renal ischemia reperfusion in mice Open
Our results suggest that the protection afforded by CsA is likely limited by its availability. The dose and timing of the injections are therefore crucial to ensure that the treatment is effective, but these findings may prove challenging …
View article: Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice
Inhibition of PIKfyve prevents myocardial apoptosis and hypertrophy through activation of SIRT3 in obese mice Open