Demiën Broekhuis
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View article: The risk of pathological fractures after intralesional curettage in Atypical Cartilaginous Tumours: A retrospective cohort study
The risk of pathological fractures after intralesional curettage in Atypical Cartilaginous Tumours: A retrospective cohort study Open
Purpose: Atypical cartilaginous tumors (ACT) are locally aggressive, cartilage-producing neoplasms, traditionally classified as chondrosarcoma grade 1. They exist within the spectrum of cartilaginous tumors, between enchondroma and high-gr…
View article: Additively manufactured shape-morphing implants for the treatment of acetabular defects
Additively manufactured shape-morphing implants for the treatment of acetabular defects Open
Acetabular defects pose significant challenges in orthopedic surgery, particularly in revision total hip arthroplasty (THA). Here, we design, additively manufacture, and evaluate shape-morphing porous implants with kinematic structures to …
View article: Evaluating polyethylene, polyether-ether-ketone, and metal-on-metal locking mechanism survival in Modular Universal Tumour and Revision System knee reconstructions for oncological indications
Evaluating polyethylene, polyether-ether-ketone, and metal-on-metal locking mechanism survival in Modular Universal Tumour and Revision System knee reconstructions for oncological indications Open
Aims Over time, the locking mechanism of Modular Universal Tumour and Revision System (MUTARS) knee arthroplasties changed from polyethylene (PE) to polyether-ether-ketone Optima (PEEK) and metal-on-metal (MoM) in an attempt to reduce the …
View article: Clinical outcome of curettage in atypical cartilaginous tumors of the long bones: a descriptive cohort study
Clinical outcome of curettage in atypical cartilaginous tumors of the long bones: a descriptive cohort study Open
Background and purpose: Despite evolving management strategies for atypical cartilaginous tumors (ACT)—shifting from radical resection to intralesional curettage and “wait-and-scan” approaches—there remains no universal consensus on optima…
View article: LUMiC Endoprosthetic Reconstruction of Periacetabular Tumor Defects
LUMiC Endoprosthetic Reconstruction of Periacetabular Tumor Defects Open
Update: This article was updated on July 17, 2024 because of a previous error, which was discovered after the preliminary version of the article was posted online. The byline that had read “Richard E. Evenhuis, MD 1 , Michiel A.J. van de S…
View article: High accuracy of positioning custom triflange acetabular components in tumour and total hip arthroplasty revision surgery
High accuracy of positioning custom triflange acetabular components in tumour and total hip arthroplasty revision surgery Open
Aims Custom triflange acetabular components (CTACs) play an important role in reconstructive orthopaedic surgery, particularly in revision total hip arthroplasty (rTHA) and pelvic tumour resection procedures. Accurate CTAC positioning is e…
View article: An open comminuted tibia fracture including a 5 cm tibial bone defect in a child: Successful management using a locking compression plate
An open comminuted tibia fracture including a 5 cm tibial bone defect in a child: Successful management using a locking compression plate Open
Traumatic bone defects (TBDs), although rare in children, are severe injuries that often represents a challenge for both orthopaedic and trauma surgeons. We present a case of a 6-year-old girl who sustained an open (Gustilo-Anderson type I…
View article: Mechanical stress and inflammation have opposite effects on Wnt signaling in human chondrocytes
Mechanical stress and inflammation have opposite effects on Wnt signaling in human chondrocytes Open
Dysregulation of Wingless and Int‐1 (Wnt) signaling has been strongly associated with development and progression of osteoarthritis (OA). Here, we set out to investigate the independent effects of either mechanical stress (MS) or inflammat…
View article: Osteomyelitis caused by Streptococcus intermedius in immunocompetent adults — a case report and systematic literature review
Osteomyelitis caused by Streptococcus intermedius in immunocompetent adults — a case report and systematic literature review Open
Hematogenous osteomyelitis caused by Streptococcus intermedius is rare, particularly in immunocompetent adults. The aim of this paper is to provide an overview of the clinical presentation, prognosis as well as treatment of this disease, w…
View article: Custom triflange acetabular components for large acetabular defect reconstruction in revision total hip arthroplasty: a systematic review and meta-analysis on 1218 patients
Custom triflange acetabular components for large acetabular defect reconstruction in revision total hip arthroplasty: a systematic review and meta-analysis on 1218 patients Open
Purpose This is a systematic review and meta(regression) analysis to assess the performance of custom triflange acetabular components (CTAC) in total hip arthroplasty (THA) revision surgery. Implant-related complications, failure rate, fun…
View article: Custom designed and 3D-printed titanium pelvic implants for acetabular reconstruction after tumour resection
Custom designed and 3D-printed titanium pelvic implants for acetabular reconstruction after tumour resection Open
Background: Reconstructive procedure following resection of large pelvic tumours around the hip joint remains a complex challenge. Methods: This study presents a retrospective case series of patients presenting with benign or malignant pel…
View article: Systemic Metal Ion Concentrations in Patients With Hip and Knee Megaprostheses: A Prospective Cohort Study
Systemic Metal Ion Concentrations in Patients With Hip and Knee Megaprostheses: A Prospective Cohort Study Open
This study documents significantly elevated concentrations of the metal ions, but only one adverse effect directly related to the metal ion concentrations was observed. Future studies are needed to further assess the impact of elevated met…
View article: Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes
Inhibiting thyroid activation in aged human explants prevents mechanical induced detrimental signalling by mitigating metabolic processes Open
Objectives To investigate whether the deiodinase inhibitor iopanoic acid (IOP) has chondroprotective properties, a mechanical stress induced model of human aged explants was used to test both repeated dosing and slow release of IOP. Method…
View article: Long non-coding RNA expression profiling of subchondral bone reveals <i>AC005165.1</i> modifying <i>FRZB</i> expression during osteoarthritis
Long non-coding RNA expression profiling of subchondral bone reveals <i>AC005165.1</i> modifying <i>FRZB</i> expression during osteoarthritis Open
Objective To gain insight in the expression profile of long non-coding RNAs (lncRNAs) in OA subchondral bone. Methods RNA sequencing data of macroscopically preserved and lesioned OA subchondral bone of patients that underwent joint replac…
View article: Elucidating Epigenetic Regulation by Identifying Functional <i>cis</i>‐Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage
Elucidating Epigenetic Regulation by Identifying Functional <i>cis</i>‐Acting Long Noncoding RNAs and Their Targets in Osteoarthritic Articular Cartilage Open
Objective To identify robustly differentially expressed long noncoding RNAs (lncRNAs) with osteoarthritis (OA) pathophysiology in cartilage and to explore potential target messenger RNA (mRNA) by establishing coexpression networks, followe…
View article: Elucidating another level of epigenetic regulation in osteoarthritis by identifying functional<i>cis</i>-acting long non-coding RNAs and their targets in articular cartilage
Elucidating another level of epigenetic regulation in osteoarthritis by identifying functional<i>cis</i>-acting long non-coding RNAs and their targets in articular cartilage Open
Objective To identify robustly differentially expressed long non-coding RNAs (lncRNAs) with osteoarthritis (OA) pathophysiology in cartilage. Moreover to explore potential target mRNAs by establishing co-expression networks, followed by fu…
View article: Anaesthetic challenges for pelvic reconstruction with custom three-dimensional-printed titanium implants: A retrospective cohort study
Anaesthetic challenges for pelvic reconstruction with custom three-dimensional-printed titanium implants: A retrospective cohort study Open
Custom 3D printed titanium implant pelvic reconstructive surgery was implemented as a novel technique at our institutions in the last five years. It provided an option for pelvic bone malignancy patients who were previously deemed unsuitab…