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View article: Comparative effectiveness of interventions to facilitate deprescription of benzodiazepines and other sedative hypnotics: systematic review and meta-analysis
Comparative effectiveness of interventions to facilitate deprescription of benzodiazepines and other sedative hypnotics: systematic review and meta-analysis Open
Objective To review evidence from randomised trials assessing the effectiveness of strategies to deprescribe benzodiazepines and closely related sedative hypnotics (BSH). Design Systematic review and meta-analysis of randomised controlled …
View article: Impact of the COVID-19 Pandemic and the 2021 National Institute for Health and Care Excellence Guidelines on Public Perspectives Toward Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Thematic and Sentiment Analysis on Twitter (Rebranded as X)
Impact of the COVID-19 Pandemic and the 2021 National Institute for Health and Care Excellence Guidelines on Public Perspectives Toward Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Thematic and Sentiment Analysis on Twitter (Rebranded as X) Open
Background Myalgic encephalomyelitis (ME), also referred to as chronic fatigue syndrome (CFS), is a complex illness that typically presents with disabling fatigue and cognitive and functional impairment. The etiology and management of ME/C…
View article: Metformin for covid-19: systematic review and meta-analysis of randomised controlled trials
Metformin for covid-19: systematic review and meta-analysis of randomised controlled trials Open
Objective To summarise the effects of metformin on covid-19 to inform a World Health Organization (WHO) clinical practice guideline. Design Systematic review and meta-analysis. Data sources As part of a living systematic review and network…
View article: Tacrolimus versus cyclosporine immunosuppression in lung transplantation: a systematic review and meta-analysis
Tacrolimus versus cyclosporine immunosuppression in lung transplantation: a systematic review and meta-analysis Open
Background The relative efficacy of calcineurin inhibitors tacrolimus and cyclosporine in lung transplantation remains unclear. To clarify, we conducted a systematic review and meta-analysis. Methods We searched through EMBASE, MEDLINE and…
View article: Development of ROBUST-RCT: Risk Of Bias instrument for Use in SysTematic reviews-for Randomised Controlled Trials
Development of ROBUST-RCT: Risk Of Bias instrument for Use in SysTematic reviews-for Randomised Controlled Trials Open
View article: Interventions for the management of post-COVID-19 condition (long COVID): protocol for a living systematic review and network meta-analysis
Interventions for the management of post-COVID-19 condition (long COVID): protocol for a living systematic review and network meta-analysis Open
Background Up to 15% of survivors of COVID-19 infection experience long-term health effects, including fatigue, myalgia and impaired cognitive function, termed post-COVID-19 condition or long COVID. Several trials that study the benefits a…
View article: An exploration of the increasing prevalence of chronic pain among Canadian veterans: Life After Service Studies 2016 and 2019
An exploration of the increasing prevalence of chronic pain among Canadian veterans: Life After Service Studies 2016 and 2019 Open
The increase in chronic pain among Canadian veterans from 2016 to 2019 appears confounded by increased comorbidities associated with chronic pain among responders in 2019.
View article: Biologic Therapies for Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Biologic Therapies for Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials Open
Dupilumab is effective at improving patient-relevant outcomes in COPD with higher eosinophil levels. Other biological therapies, including tezepelumab, have no important effect on patient-relevant outcomes.
View article: Best practices for guideline development in Critical Care
Best practices for guideline development in Critical Care Open
View article: Magnesium for Prevention of New-onset Postoperative Atrial Fibrillation Following Cardiac Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Magnesium for Prevention of New-onset Postoperative Atrial Fibrillation Following Cardiac Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials Open
The evidence indicates that magnesium administration reduces the incidence of new-onset POAF.
View article: Interventions for the management of long covid (post-covid condition): living systematic review
Interventions for the management of long covid (post-covid condition): living systematic review Open
Objective To compare the effectiveness of interventions for the management of long covid (post-covid condition). Design Living systematic review. Data sources Medline, Embase, CINAHL, PsycInfo, Allied and Complementary Medicine Database, a…
View article: Treatment of Critical Bleeds in Patients With Immune Thrombocytopenia: A Systematic Review
Treatment of Critical Bleeds in Patients With Immune Thrombocytopenia: A Systematic Review Open
Objectives Evidence‐based protocols for managing bleeding emergencies in patients with immune thrombocytopenia (ITP) are lacking. We conducted a systematic review of treatments for critical bleeding in patients with ITP. Methods We include…
View article: Exposure to air pollutants and subclinical carotid atherosclerosis measured by magnetic resonance imaging: A cross-sectional analysis
Exposure to air pollutants and subclinical carotid atherosclerosis measured by magnetic resonance imaging: A cross-sectional analysis Open
Objectives Long-term exposure to air pollution has been associated with higher risk of cardiovascular mortality. Less is known about the association of air pollution with initial development of cardiovascular disease. Herein, the associati…
View article: Effectiveness of Anti-Inflammatory Agents to Prevent Atrial Fibrillation After Cardiac Surgery: A Systematic Review and Network Meta-Analysis
Effectiveness of Anti-Inflammatory Agents to Prevent Atrial Fibrillation After Cardiac Surgery: A Systematic Review and Network Meta-Analysis Open
Use of nonsteroidal anti-inflammatory drugs and statins probably are effective in preventing new-onset POAF, with a moderate level of certainty, compared to placebo.
View article: Proactive therapeutic drug monitoring of biologic drugs in patients with inflammatory bowel disease, inflammatory arthritis, and psoriasis: systematic review and meta-analysis
Proactive therapeutic drug monitoring of biologic drugs in patients with inflammatory bowel disease, inflammatory arthritis, and psoriasis: systematic review and meta-analysis Open
Objective To address the efficacy and safety of proactive therapeutic drug monitoring of biologic drugs for patients with inflammatory bowel disease, inflammatory arthritis, and psoriasis. Design Systematic review and meta-analysis. Data s…
View article: Impact of the COVID-19 Pandemic and the 2021 National Institute for Health and Care Excellence Guidelines on Public Perspectives Toward Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Thematic and Sentiment Analysis on Twitter (Rebranded as X) (Preprint)
Impact of the COVID-19 Pandemic and the 2021 National Institute for Health and Care Excellence Guidelines on Public Perspectives Toward Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Thematic and Sentiment Analysis on Twitter (Rebranded as X) (Preprint) Open
BACKGROUND Myalgic encephalomyelitis (ME), also referred to as chronic fatigue syndrome (CFS), is a complex illness that typically presents with disabling fatigue and cognitive and functional impairment. The etiology and management of ME/…
View article: Nutrition users’ guides: systematic reviews part 1 –structured guide for methodological assessment, interpretation and application of systematic reviews and meta-analyses of non-randomised nutritional epidemiology studies
Nutrition users’ guides: systematic reviews part 1 –structured guide for methodological assessment, interpretation and application of systematic reviews and meta-analyses of non-randomised nutritional epidemiology studies Open
Due to the challenges of conducting randomised controlled trials (randomised trials) of dietary interventions, evidence in nutrition often comes from non-randomised (observational) studies of nutritional exposures—called nutritional epidem…
View article: European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention - part 4: propranolol
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention - part 4: propranolol Open
Objective The aim of this paper is to critically re-appraise the published trials assessing propranolol for migraine prophylaxis. Methods We report methods and results following the Preferred Reporting Items for Systematic Reviews (PRISMA)…
View article: Values and preferences in COVID-19 public health guidelines: a systematic review
Values and preferences in COVID-19 public health guidelines: a systematic review Open
View article: Challenges in Appraising Nutrition Evidence: A Scoping Review
Challenges in Appraising Nutrition Evidence: A Scoping Review Open
View article: Grilling the Data: Interpreting the Results of Nutritional Epidemiology Studies in the Context of Variation Expected Due to Analytic Flexibility
Grilling the Data: Interpreting the Results of Nutritional Epidemiology Studies in the Context of Variation Expected Due to Analytic Flexibility Open
View article: Specification curve analysis to identify heterogeneity in risk factors for dementia: findings from the UK Biobank
Specification curve analysis to identify heterogeneity in risk factors for dementia: findings from the UK Biobank Open
Background In 2020, the Lancet Commission identified 12 risk factors as priorities for prevention of dementia, and other studies identified APOE e4/e4 genotype and family history of Alzheimer’s disease strongly associated with dementia out…
View article: Physicians found an interactive tool displaying structured evidence summaries for multiple comparisons understandable and useful: a qualitative user testing study
Physicians found an interactive tool displaying structured evidence summaries for multiple comparisons understandable and useful: a qualitative user testing study Open
OBJECTIVES: To evaluate and improve "Making Alternative Treatment Choices Intuitive and Trustworthy" (MATCH-IT)-a digital, interactive decision support tool displaying structured evidence summaries for multiple comparisons-to help physicia…
View article: Research Transparency in 59 Disciplines of Clinical Medicine: A Meta-Research Study
Research Transparency in 59 Disciplines of Clinical Medicine: A Meta-Research Study Open
Background: Transparency in health research is crucial as it allows for the scrutiny and replication of findings, fosters confidence in scientific outcomes, and ultimately contributes to the advancement of knowledge and the betterment of s…
View article: Research Transparency in 59 Disciplines of Clinical Medicine: A Meta-Research Study
Research Transparency in 59 Disciplines of Clinical Medicine: A Meta-Research Study Open
Background Transparency in health research is crucial as it allows for the scrutiny and replication of findings, fosters confidence in scientific outcomes, and ultimately contributes to the advancement of knowledge and the betterment of so…
View article: Values and preferences in COVID-19 public health guidelines: A systematic review
Values and preferences in COVID-19 public health guidelines: A systematic review Open
Background Internationally accepted standards for trustworthy guidelines include the necessity to ground recommendations in values and preferences. Considering values and preferences respects the rights of citizens to participate in health…
View article: Interventions for the management of post COVID-19 condition (long COVID): Protocol for a living systematic review & network meta-analysis
Interventions for the management of post COVID-19 condition (long COVID): Protocol for a living systematic review & network meta-analysis Open
Background Up to 15% of survivors of COVID-19 infection experience long-term health effects, including fatigue, myalgia, and impaired cognitive function, termed post COVID-19 condition or long COVID. Several trials that study the benefits …
View article: Grilling the data: application of specification curve analysis to red meat and all-cause mortality
Grilling the data: application of specification curve analysis to red meat and all-cause mortality Open
View article: The ophthalmologist’s guide to evaluating the certainty of evidence using the GRADE approach
The ophthalmologist’s guide to evaluating the certainty of evidence using the GRADE approach Open
View article: Variations in the results of nutritional epidemiology studies due to analytic flexibility: Application of specification curve analysis to red meat and all-cause mortality
Variations in the results of nutritional epidemiology studies due to analytic flexibility: Application of specification curve analysis to red meat and all-cause mortality Open
Objective To present an application of specification curve analysis—a novel analytic method that involves defining and implementing all plausible and valid analytic approaches for addressing a research question—to nutritional epidemiology.…