Dongdong Su
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View article: LAG: Logic-Augmented Generation from a Cartesian Perspective
LAG: Logic-Augmented Generation from a Cartesian Perspective Open
Large language models (LLMs) have demonstrated remarkable capabilities across a wide range of tasks, yet exhibit critical limitations in knowledge-intensive tasks, often generating hallucinations when faced with questions requiring special…
View article: Association of serum Klotho with tinnitus prevalence, duration and severity: A cross-sectional study in middle-aged and older adults
Association of serum Klotho with tinnitus prevalence, duration and severity: A cross-sectional study in middle-aged and older adults Open
Background As an anti-aging protein, although studies increasingly suggest that the Klotho plays a role in the auditory system, the link between serum Klotho levels and tinnitus remains poorly characterized. The aim of this study was to in…
View article: Role of vertebral fat fraction and R2* based on fat analysis and calculation technique in the quantitative assessment of osteoporosis
Role of vertebral fat fraction and R2* based on fat analysis and calculation technique in the quantitative assessment of osteoporosis Open
View article: Cyclodextrin-Based Pickering Emulsion Significantly Increases 6-Gingerol Loading Through Two Different Mechanisms: Cyclodextrin Cavity and Pickering Core
Cyclodextrin-Based Pickering Emulsion Significantly Increases 6-Gingerol Loading Through Two Different Mechanisms: Cyclodextrin Cavity and Pickering Core Open
We previously found that host–guest interactions can drive gingerols (Gs) and cyclodextrins (CDs) together to form inclusion complexes (G/CD), which can further construct amphiphilic microcrystals and resultant Pickering emulsions through …
View article: Benchmarking LLMs' Mathematical Reasoning with Unseen Random Variables Questions
Benchmarking LLMs' Mathematical Reasoning with Unseen Random Variables Questions Open
Recent studies have raised significant concerns regarding the reliability of current mathematics benchmarks, highlighting issues such as simplistic design and potential data contamination. Consequently, developing a reliable benchmark that…
View article: Spatio-Temporal Photovoltaic Power Prediction with Fourier Graph Neural Network
Spatio-Temporal Photovoltaic Power Prediction with Fourier Graph Neural Network Open
The strong development of distributed energy sources has become one of the most important measures for low-carbon development worldwide. With a significant quantity of photovoltaic (PV) power generation being integrated to the grid, accura…
View article: NaHS alleviates neuropathic pain in mice by inhibiting IL-17-mediated dopamine (DA) neuron necroptosis in the VTA
NaHS alleviates neuropathic pain in mice by inhibiting IL-17-mediated dopamine (DA) neuron necroptosis in the VTA Open
H2S therapy reduces CCI-induced neuropathic pain in mice. This protective mechanism may be linked to the prevention of IL-17-induced necroptosis of dopamine neurons in the VTA.
View article: Recent advances in self‐immobilizing fluorescent probes for in vivo imaging
Recent advances in self‐immobilizing fluorescent probes for in vivo imaging Open
In situ precise detection of bioactive molecules with high sensitivity and spatiotemporal resolution is essential for studying physiological events and disease diagnosis. The utilization of versatile fluorescent probes in fluorescence imag…
View article: Site-Specific Cascade-Activatable Fluorogenic Nanomicelles Enable Precision and Accuracy Imaging of Pulmonary Metastatic Tumor
Site-Specific Cascade-Activatable Fluorogenic Nanomicelles Enable Precision and Accuracy Imaging of Pulmonary Metastatic Tumor Open
The precise localization of metastatic tumors with subtle growth is crucial for timely intervention and improvement of tumor prognosis but remains a paramount challenging. To date, site-specific activation of fluorogenic probes for single-…
View article: A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF
A probe for NIR-II imaging and multimodal analysis of early Alzheimer’s disease by targeting CTGF Open
To date, earlier diagnosis of Alzheimer’s disease (AD) is still challenging. Recent studies revealed the elevated expression of connective tissue growth factor (CTGF) in AD brain is an upstream regulator of amyloid-beta (Aβ) plaque, thus C…
View article: Flight verification of cooling self-sustaining high-temperature superconducting motor
Flight verification of cooling self-sustaining high-temperature superconducting motor Open
The global shift towards sustainable development and technological advancements has propelled the energy transition trend. Recognizing the substantial environmental impact of conventional commercial airplanes, there is a growing urgency to…
View article: A simple yet effective H<sub>2</sub>S‐activated fluorogenic probe for precise imaging of hepatitis and arthritis in situ
A simple yet effective H<sub>2</sub>S‐activated fluorogenic probe for precise imaging of hepatitis and arthritis in situ Open
Hepatitis and arthritis are prevalent inflammatory diseases, and the utilization of fluorogenic probes incorporating hydrogen sulfide (H 2 S) as a crucial mediator of inflammation presents significant opportunities for early detection. How…
View article: Enhancing Liver Delivery of Gold Nanoclusters via Human Serum Albumin Encapsulation for Autoimmune Hepatitis Alleviation
Enhancing Liver Delivery of Gold Nanoclusters via Human Serum Albumin Encapsulation for Autoimmune Hepatitis Alleviation Open
Peptide-protected gold nanoclusters (AuNCs), possessing exceptional biocompatibility and remarkable physicochemical properties, have demonstrated intrinsic pharmaceutical activity in immunomodulation, making them a highly attractive fronti…
View article: Frontispiece: Visual genetic typing of glioma using proximity‐anchored in situ spectral coding amplification (EXP2 5/2023)
Frontispiece: Visual genetic typing of glioma using proximity‐anchored in situ spectral coding amplification (EXP2 5/2023) Open
View article: Visual genetic typing of glioma using proximity‐anchored in situ spectral coding amplification
Visual genetic typing of glioma using proximity‐anchored in situ spectral coding amplification Open
Gliomas are histologically and genetically heterogeneous tumors. However, classical histopathological typing often ignores the high heterogeneity of tumors and thus cannot meet the requirements of precise pathological diagnosis. Here, prox…
View article: Recent Progress in Fluorescent Probes for the Detection and Research of Hydrogen Sulfide in Cells
Recent Progress in Fluorescent Probes for the Detection and Research of Hydrogen Sulfide in Cells Open
Hydrogen sulfide (H2S) is a gaseous signaling molecule that plays an important role in regulating various physiological activities in biological systems. As the fundamental structural and functional unit of organisms, cells are closely rel…
View article: Study on host-guest interaction of aroma compounds/γ-cyclodextrin inclusion complexes
Study on host-guest interaction of aroma compounds/γ-cyclodextrin inclusion complexes Open
View article: Image‐guided diagnosis and treatment of glioblastoma
Image‐guided diagnosis and treatment of glioblastoma Open
Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis and high recurrence rate. The presence of the blood–brain barrier (BBB) prevents diagnostic and therapeutic drugs from penetrating and working in GBM. In tra…
View article: Enzyme-activated near-infrared fluorogenic probe with high-efficiency intrahepatic targeting ability for visualization of drug-induced liver injury
Enzyme-activated near-infrared fluorogenic probe with high-efficiency intrahepatic targeting ability for visualization of drug-induced liver injury Open
We rationally designed a leucine aminopeptidase (LAP) activated fluorogenic probe hCy-CA-LAP with high hepatocyte-targeting ability for accurate and sensitive imaging of DILI.
View article: Cell membranes targeted unimolecular prodrug for programmatic photodynamic-chemo therapy
Cell membranes targeted unimolecular prodrug for programmatic photodynamic-chemo therapy Open
Photodynamic therapy (PDT) has emerged as one of the most up-and-coming non-invasive therapeutic modalities for cancer therapy in rencent years. However, its therapeutic effect was still hampered by the short life span, limited diffusion d…
View article: Peptide and protein modified metal clusters for cancer diagnostics
Peptide and protein modified metal clusters for cancer diagnostics Open
A perspective on the development of peptide and protein modified metal clusters in cancer diagnostic applications.
View article: Noble-metal nanocluster as enzyme-mimetic catalyst for diagnostic analysis
Noble-metal nanocluster as enzyme-mimetic catalyst for diagnostic analysis Open
View article: An ESIPT‐Based Ratiometric Fluorescent Probe for Highly Sensitive and Rapid Detection of Sulfite in Living Cells
An ESIPT‐Based Ratiometric Fluorescent Probe for Highly Sensitive and Rapid Detection of Sulfite in Living Cells Open
The novel ratiometric fluorescent probe HPQRB with an ESIPT effect based on Michael addition for highly sensitive and fast detection of sulfite in living HepG2 cells is reported. HPQRB can be easily synthesized by a two‐step condensation r…
View article: Frontispiz: Visualizing Microglia with a Fluorescence Turn‐On Ugt1a7c Substrate
Frontispiz: Visualizing Microglia with a Fluorescence Turn‐On Ugt1a7c Substrate Open
Fluoreszenzsonden In ihrer Zuschrift auf S. 8056 beschreiben H. S. Je, Y.-T. Chang et al. die Bildgebung lebender Mikroglia mit der Sonde CDr20. Ugt1a7c katalysiert die Glucuronidierung von CDr20, was zu roter Fluoreszenz führt.
View article: A fast responsive chromogenic and near-infrared fluorescence lighting-up probe for visual detection of toxic thiophenol in environmental water and living cells
A fast responsive chromogenic and near-infrared fluorescence lighting-up probe for visual detection of toxic thiophenol in environmental water and living cells Open
View article: Seeing Elastin: A Near-Infrared Zwitterionic Fluorescent Probe for In Vivo Elastin Imaging
Seeing Elastin: A Near-Infrared Zwitterionic Fluorescent Probe for In Vivo Elastin Imaging Open
View article: Detection of analytes in mitochondria without interference from other sites based on an innovative ratiometric fluorophore
Detection of analytes in mitochondria without interference from other sites based on an innovative ratiometric fluorophore Open
A new strategy that integrates the targeting group and response moiety together for the preparation of mitochondrial probe was developed. Bioimaging studies have shown that for the first time, the newly designed probeHDFL-Cyscan first accu…
View article: A palette of background-free tame fluorescent probes for intracellular multi-color labelling in live cells
A palette of background-free tame fluorescent probes for intracellular multi-color labelling in live cells Open
A palette of background-free tame fluorescent probes were designed and applied to intracellular multi-color labelling in live cells.
View article: A new approach for turn-on fluorescence sensing of l-DOPA
A new approach for turn-on fluorescence sensing of l-DOPA Open
Resa-Sulf, designed based on a redox reaction, was applied for turn-on fluorescence sensing and quantitative detection ofl-DOPA.
View article: A Simple BODIPY-Based Viscosity Probe for Imaging of Cellular Viscosity in Live Cells
A Simple BODIPY-Based Viscosity Probe for Imaging of Cellular Viscosity in Live Cells Open
Intracellular viscosity is a fundamental physical parameter that indicates the functioning of cells. In this work, we developed a simple boron-dipyrromethene (BODIPY)-based probe, BTV, for cellular mitochondria viscosity imaging by couplin…