Hong‐Wen Deng
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View article: A safety assessment method for substation system dynamics adapted to high penetration of distributed renewable energy sources with backward flow delivery
A safety assessment method for substation system dynamics adapted to high penetration of distributed renewable energy sources with backward flow delivery Open
The integration of high-penetration distributed renewable energy sources into new power systems introduces significant challenges, particularly frequent reverse power flows that threaten substation security. To address this issue, this pap…
View article: PF-DAformer: Proximal Femur Segmentation via Domain Adaptive Transformer for Dual-Center QCT
PF-DAformer: Proximal Femur Segmentation via Domain Adaptive Transformer for Dual-Center QCT Open
Quantitative computed tomography (QCT) plays a crucial role in assessing bone strength and fracture risk by enabling volumetric analysis of bone density distribution in the proximal femur. However, deploying automated segmentation models i…
View article: An Advanced Two-Stage Model with High Sensitivity and Generalizability for Prediction of Hip Fracture Risk Using Multiple Datasets
An Advanced Two-Stage Model with High Sensitivity and Generalizability for Prediction of Hip Fracture Risk Using Multiple Datasets Open
Hip fractures are a major cause of disability, mortality, and healthcare burden in older adults, underscoring the need for early risk assessment. However, commonly used tools such as the DXA T-score and FRAX often lack sensitivity and miss…
View article: Hypothalamic subunit volumes in schizophrenia with comorbidity of metabolic syndrome
Hypothalamic subunit volumes in schizophrenia with comorbidity of metabolic syndrome Open
Schizophrenia and metabolic syndrome (MS) are common conditions that frequently co-occur, yet the neurobiological mechanisms underlying their comorbidity remain unclear. This study aimed to investigate whether hypothalamic structural alter…
View article: High-throughput characterization of 5886 HER2 variants identifies 112 new in cellulo gain-of-function mutations
High-throughput characterization of 5886 HER2 variants identifies 112 new in cellulo gain-of-function mutations Open
ERBB2 (HER2) is a well-studied oncogene with several driver mutations apart from the well-known amplification defect in some breast cancers. We used the GigaAssay to test the functional effect of HER2 missense mutations on its receptor tyr…
View article: Personalized Federated Dictionary Learning for Modeling Heterogeneity in Multi-site fMRI Data
Personalized Federated Dictionary Learning for Modeling Heterogeneity in Multi-site fMRI Data Open
Data privacy constraints pose significant challenges for large-scale neuroimaging analysis, especially in multi-site functional magnetic resonance imaging (fMRI) studies, where site-specific heterogeneity leads to non-independent and ident…
View article: Phenotypic and Genetic Associations Between Cardiovascular Disease Subtypes and Alzheimer’s Disease
Phenotypic and Genetic Associations Between Cardiovascular Disease Subtypes and Alzheimer’s Disease Open
Background Cardiovascular disease (CVD) and Alzheimer’s disease (AD) are major public health concerns that share overlapping risk factors and potential mechanistic pathways. While vascular contributions to cognitive decline are well-docume…
View article: Slit2 inhibits SRC-PI3K signaling pathway, regulates osteoclast differentiation of macrophages and reduces bone resorption
Slit2 inhibits SRC-PI3K signaling pathway, regulates osteoclast differentiation of macrophages and reduces bone resorption Open
Osteoporosis is a metabolic disorder characterized by increased bone resorption and decreased bone formation. As a well-characterized axon guidance molecule, Slit2 contributes to central nervous system regulation by modulating intracellula…
View article: BiU-Net: A Biologically Informed U-Net for Genotype Imputation
BiU-Net: A Biologically Informed U-Net for Genotype Imputation Open
Missing genotypes reduce statistical power and hinder genome-wide association studies. While reference-based methods are popular, they struggle in complex regions and under population mismatch. Existing reference-free deep learning models …
View article: Novel Pathological Mechanisms Revealed by Spatial Transcriptomic Analysis of Hippocampus in Aged Control, Primary Age-Related Tauopathy, and Alzheimer’s Disease
Novel Pathological Mechanisms Revealed by Spatial Transcriptomic Analysis of Hippocampus in Aged Control, Primary Age-Related Tauopathy, and Alzheimer’s Disease Open
View article: DNA Barcode Reference Library and Undetected Diversity of Fish Species in the Yuanjiang River, China
DNA Barcode Reference Library and Undetected Diversity of Fish Species in the Yuanjiang River, China Open
The Yuanjiang River, situated in the upper reaches of the Red River, is a crucial component of a biodiversity hotspot in the mountains of southwestern China, supporting a high diversity of fish species. Nevertheless, systematic research on…
View article: <i>Porphyromonas gingivalis</i> OMVs inhibit osteogenic differentiation of BMSCs via SAA3/TLR4/MyD88/NF-κB axis
<i>Porphyromonas gingivalis</i> OMVs inhibit osteogenic differentiation of BMSCs via SAA3/TLR4/MyD88/NF-κB axis Open
Our results indicate that P.g-OMVs inhibit osteogenic differentiation of BMSCs via the SAA3-mediated TLR4/MyD88/NF-κB axis, providing novel targets for the treatment of periodontitis-induced alveolar bone loss.
View article: Integrative snRNA‐seq, molecular docking and dynamics simulations identifies Lasmiditan as drug candidate for Alzheimer's disease
Integrative snRNA‐seq, molecular docking and dynamics simulations identifies Lasmiditan as drug candidate for Alzheimer's disease Open
Background Alzheimer's disease (AD) is a growing healthcare crisis with limited effective therapies. This study aims to identify new candidate drugs that can be repurposed using key transcriptional regulators (DERs) in AD as therapeutic ta…
View article: Influence of process parameters on bubble formation and melt pool dynamics during laser directed energy deposition via in-situ synchrotron X-ray imaging
Influence of process parameters on bubble formation and melt pool dynamics during laser directed energy deposition via in-situ synchrotron X-ray imaging Open
View article: DNA Barcode Reference Library and Undetected Diversity of Fish Species in the Yuanjiang River, China
DNA Barcode Reference Library and Undetected Diversity of Fish Species in the Yuanjiang River, China Open
The Yuanjiang River, located in the upper reaches of the Red River, constitutes a critical part of the Mountains of Southwest China biodiversity hotspot, which supports a high diversity of fish species. Nevertheless, relatively systematic …
View article: Decoding Cellular Communication Networks and Signaling Pathways in Bone, Skeletal Muscle, and Bone-Muscle Crosstalk Through Spatial Transcriptomics
Decoding Cellular Communication Networks and Signaling Pathways in Bone, Skeletal Muscle, and Bone-Muscle Crosstalk Through Spatial Transcriptomics Open
View article: Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis
Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis Open
Osteoporosis is a common metabolic bone disease with aging, characterized by low bone mineral density (BMD) and higher fragility fracture risk. Although current pharmacological interventions provide therapeutic benefits, long‐term use is l…
View article: Supplementary Table S1 from Inhibition of DKK-1 by WAY262611 Inhibits Osteosarcoma Metastasis
Supplementary Table S1 from Inhibition of DKK-1 by WAY262611 Inhibits Osteosarcoma Metastasis Open
Supplementary Table S1: Top 10 GO Biological Processes Enriched in Treated vs Control
View article: Supplementary Figure S1 from Inhibition of DKK-1 by WAY262611 Inhibits Osteosarcoma Metastasis
Supplementary Figure S1 from Inhibition of DKK-1 by WAY262611 Inhibits Osteosarcoma Metastasis Open
Supplementary Figure S1 shows results from toxicity evaluation of WAY262611, the effect of WAY262611 on the growth of the primary tumor and on mouse survival, as well as examples of metastatic lesions.
View article: Data from Inhibition of DKK-1 by WAY262611 Inhibits Osteosarcoma Metastasis
Data from Inhibition of DKK-1 by WAY262611 Inhibits Osteosarcoma Metastasis Open
Osteosarcoma is the most common primary malignant bone tumor in childhood. Patients who present with metastatic disease at diagnosis or relapse have a very poor prognosis, and this has not changed over the past four decades. The Wnt signal…
View article: Integration of Bioinformatics and Machine Learning Strategies Identifies Ferroptosis and Immune Infiltration Signatures in Peri-Implantitis
Integration of Bioinformatics and Machine Learning Strategies Identifies Ferroptosis and Immune Infiltration Signatures in Peri-Implantitis Open
Peri-implantitis (PI) is a chronic inflammatory disease that ultimately leads to the dysfunction and loss of implants with established osseointegration. Ferroptosis has been implicated in the progression of PI, but its precise mechanisms r…
View article: ICGM-FRAX: Iterative Cross Graph Matching for Hip Fracture Risk Assessment using Dual-energy X-ray Absorptiometry Images
ICGM-FRAX: Iterative Cross Graph Matching for Hip Fracture Risk Assessment using Dual-energy X-ray Absorptiometry Images Open
Hip fractures represent a major health concern, particularly among the elderly, often leading decreased mobility and increased mortality. Early and accurate detection of at risk individuals is crucial for effective intervention. In this st…
View article: An Attention‐Aware Multi‐Task Learning Framework Identifies Candidate Targets for Drug Repurposing in Sarcopenia
An Attention‐Aware Multi‐Task Learning Framework Identifies Candidate Targets for Drug Repurposing in Sarcopenia Open
Background Sarcopenia presents a pressing public health concern due to its association with age‐related muscle mass decline, strength loss and reduced physical performance, particularly in the growing older population. Given the absence of…
View article: Rethinking Spiking Neural Networks from an Ensemble Learning Perspective
Rethinking Spiking Neural Networks from an Ensemble Learning Perspective Open
Spiking neural networks (SNNs) exhibit superior energy efficiency but suffer from limited performance. In this paper, we consider SNNs as ensembles of temporal subnetworks that share architectures and weights, and highlight a crucial issue…
View article: A Privacy-Preserving Domain Adversarial Federated learning for multi-site brain functional connectivity analysis
A Privacy-Preserving Domain Adversarial Federated learning for multi-site brain functional connectivity analysis Open
Resting-state functional magnetic resonance imaging (rs-fMRI) and its derived functional connectivity networks (FCNs) have become critical for understanding neurological disorders. However, collaborative analyses and the generalizability o…
View article: Mapping the spatial atlas of the human bone tissue integrating spatial and single-cell transcriptomics
Mapping the spatial atlas of the human bone tissue integrating spatial and single-cell transcriptomics Open
Bone is a multifaceted tissue requiring orchestrated interplays of diverse cells within specialized microenvironments. Although significant progress has been made in understanding cellular and molecular mechanisms of component cells of bon…
View article: Stereo-seq of the prefrontal cortex in aging and Alzheimer’s disease
Stereo-seq of the prefrontal cortex in aging and Alzheimer’s disease Open
View article: The Gigaassay: A Combined High Throughput and Highly Accurate Platform for Variant Classification
The Gigaassay: A Combined High Throughput and Highly Accurate Platform for Variant Classification Open
View article: Recent Advances in Biological Applications of NaErF<sub>4</sub>-based NIR-Ⅱ Luminescent Nanomaterials
Recent Advances in Biological Applications of NaErF<sub>4</sub>-based NIR-Ⅱ Luminescent Nanomaterials Open
View article: Domain-Adversarial Personalized Federated Learning for Multi-Site Non-Iid Fmri Connectivity Analysis
Domain-Adversarial Personalized Federated Learning for Multi-Site Non-Iid Fmri Connectivity Analysis Open