Dengcheng Zhou
YOU?
Author Swipe
View article: Disruption of Hepatic Sinusoidal Homeostasis Leads to Hepatopulmonary Syndrome
Disruption of Hepatic Sinusoidal Homeostasis Leads to Hepatopulmonary Syndrome Open
Hepatopulmonary syndrome (HPS) is a pulmonary vascular complication of liver disease and/or portal hypertension. HPS manifests as impaired gas exchange and hypoxemia due to intrapulmonary vascular dilatations and shunts. In response to pri…
View article: Processing of angiocrine alarmin IL-1α in endothelial cells promotes lung and liver fibrosis
Processing of angiocrine alarmin IL-1α in endothelial cells promotes lung and liver fibrosis Open
Endothelial cell-produced IL-1α plays a unique role in promoting organ fibrosis. Furthermore, the release of this angiocrine alarmin relies on a unique molecular mechanism involving RIPK1, CASP8, and ion channel Pannexin 1.
View article: Trimethylamine-N-oxide (TMAO) mediates the crosstalk between the gut microbiota and hepatic vascular niche to alleviate liver fibrosis in nonalcoholic steatohepatitis
Trimethylamine-N-oxide (TMAO) mediates the crosstalk between the gut microbiota and hepatic vascular niche to alleviate liver fibrosis in nonalcoholic steatohepatitis Open
Liver fibrosis is one main histological characteristic of nonalcoholic steatohepatitis (NASH), a disease paralleling a worldwide surge in metabolic syndromes with no approved therapies. The role of the gut microbiota in NASH pathogenesis h…