Dengfeng Cheng
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View article: Using 18F-ML-10 PET/CT imaging to detect atherosclerosis lesions and apoptotic processes in mice
Using 18F-ML-10 PET/CT imaging to detect atherosclerosis lesions and apoptotic processes in mice Open
The 18F-ML-10 PET/CT imaging technique enables the visualization of atherosclerotic plaques that are rich in apoptotic cells.
View article: Fibroblast Activation Protein Acts as a Biomarker for Monitoring ECM Remodeling During Aortic Aneurysm via <sup>68</sup> Ga‐FAPI‐04 PET Imaging
Fibroblast Activation Protein Acts as a Biomarker for Monitoring ECM Remodeling During Aortic Aneurysm via <sup>68</sup> Ga‐FAPI‐04 PET Imaging Open
Traditional imaging modalities used to monitor the diameter of aortic aneurysms (AAs) often fail to follow pathological progression. Fibroblast activation protein (FAP), a key regulator of extracellular matrix (ECM) remodeling, plays a piv…
View article: Identification of localized moisture defects in power cables based on frequency domain reflection coefficient spectra method
Identification of localized moisture defects in power cables based on frequency domain reflection coefficient spectra method Open
Based on the frequency domain reflection method, this paper studies the reflection coefficient spectrum characteristics of the head-end of the cable. The vector network analyzer is used to obtain the logarithmic amplitude, linear amplitude…
View article: Identification of local thermal aging defects in power cables based on frequency domain reflection coefficient spectroscopy method
Identification of local thermal aging defects in power cables based on frequency domain reflection coefficient spectroscopy method Open
This paper is based on the frequency domain reflection method to measure the reflection coefficient spectrum at the first end of the cable. A vector network analyzer is used to obtain the logarithmic amplitude and phase spectra of normal c…
View article: Noninvasive Monitoring of Early Cardiac Fibrosis in Diabetic Mice by [<sup>68</sup>Ga]Ga-DOTA-FAPI-04 PET/CT Imaging
Noninvasive Monitoring of Early Cardiac Fibrosis in Diabetic Mice by [<sup>68</sup>Ga]Ga-DOTA-FAPI-04 PET/CT Imaging Open
Cardiac fibrosis represents one of the representative pathological characteristics in the diabetic heart. Active fibroblasts play an essential role in the progression of cardiac fibrosis. The technologies for noninvasive monitoring of acti…
View article: Targeting colony‐stimulating factor 1 receptor: From therapeutic drugs to diagnostic radiotracers
Targeting colony‐stimulating factor 1 receptor: From therapeutic drugs to diagnostic radiotracers Open
Colony‐stimulating factor 1 receptor (CSF1R) is highly expressed in mononuclear phagocytes and in the central nervous system. It has emerged as a promising target for tumor therapy and neuroinflammation imaging. Although therapeutic agents…
View article: Application of New Molecular Probes in the Diagnosis and Treatment of Malignant Tumors
Application of New Molecular Probes in the Diagnosis and Treatment of Malignant Tumors Open
Molecular probes, specialized tools or substances meticulously designed to bind to specific molecules or biomarkers within cells, tissues, or biological samples, play a pivotal role in various domains such as biomedical research, diagnosti…
View article: Dynamic 68Ga-DOTA0-Tyr3-octreotate positron emission tomography-computed tomography for the evaluation of pancreatic neuroendocrine tumors: a pilot study
Dynamic 68Ga-DOTA0-Tyr3-octreotate positron emission tomography-computed tomography for the evaluation of pancreatic neuroendocrine tumors: a pilot study Open
The uptake of 68Ga-DOTATATE by pNETs can be explained by its high Ki value and K1:k2 ratio. Dynamic 68Ga-DOTATATE PET-CT can serve as a potential tool for evaluating pNETs and support the further assessment of a larger cohort of patients.
View article: Multi-Time-Scale Volt/var Control in Distribution networks with the Coordination of PV Inverters and Capacitor Banks
Multi-Time-Scale Volt/var Control in Distribution networks with the Coordination of PV Inverters and Capacitor Banks Open
With the increasing penetration of photovoltaics (PVs) in distribution networks, PV inverters and capacitor banks (CBs) should be well utilized for volt/var control and tackle fluctuations and uncertainty introduced by PVs. This paper prop…
View article: Exploration of <sup>68</sup>Ga-DOTA-MAL as a Versatile Vehicle for Facile Labeling of a Variety of Thiol-Containing Bioactive Molecules
Exploration of <sup>68</sup>Ga-DOTA-MAL as a Versatile Vehicle for Facile Labeling of a Variety of Thiol-Containing Bioactive Molecules Open
Efficient and site-specific radiolabeling reactions are essential in molecular probe synthesis. Thus, selecting an effective method for radiolabeling that does not affect bioactivity of the molecule is critical. Varieties of bifunctional c…
View article: Dynamic Total-Body PET/CT Imaging Reveals Kinetic Distribution of 68Ga-DOTATATE in Normal Organs
Dynamic Total-Body PET/CT Imaging Reveals Kinetic Distribution of 68Ga-DOTATATE in Normal Organs Open
Objective. To investigate the biodistribution and kinetic constants of 68Ga-DOTATATE in normal organs through dynamic total-body positron emission tomography/computed tomography (PET/CT). Methods. Seven patients who experienced endoscopic …
View article: A personal acquisition time regimen of 68Ga-DOTATATE total-body PET/CT in patients with neuroendocrine tumor (NET): a feasibility study
A personal acquisition time regimen of 68Ga-DOTATATE total-body PET/CT in patients with neuroendocrine tumor (NET): a feasibility study Open
Background The injection activity of tracer, acquisition time, patient-specific photon attenuation, and large body mass, can influence on image quality. Fixed acquisition time and body mass related injection activity in clinical practice r…
View article: Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design
Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design Open
The positron emission tomography (PET) molecular imaging technology has gained universal value as a critical tool for assessing biological and biochemical processes in living subjects. The favorable chemical, physical, and nuclear characte…
View article: CD11b-Based Pre-Targeted SPECT/CT Imaging Allows for the Detection of Inflammation in Aortic Aneurysm
CD11b-Based Pre-Targeted SPECT/CT Imaging Allows for the Detection of Inflammation in Aortic Aneurysm Open
SPECT/CT imaging using the anti-CD11b-TCO/Tz-PEG11-HYNIC-99mTc based pre-targeting imaging strategy allows for the detection of inflammation in progressive AA.
View article: Noninvasive Evaluation of EGFR Expression of Digestive Tumors Using <sup>99m</sup>Tc-MAG<sub>3</sub>-Cet-F(ab′)<sub>2</sub>-Based SPECT/CT Imaging
Noninvasive Evaluation of EGFR Expression of Digestive Tumors Using <sup>99m</sup>Tc-MAG<sub>3</sub>-Cet-F(ab′)<sub>2</sub>-Based SPECT/CT Imaging Open
Purpose. This study is aimed at investigating the feasibility of cetuximab (Cet) F(ab[Formula: see text]) 2 fragment- (Cet-F(ab[Formula: see text]) 2 -) based single photon emission tomography/computed tomography (SPECT/CT) for assessing t…
View article: Feasibility of Low-Dose 68Ga-DOTATATE With Short Acquisition Time Using Total-Body PET/CT in Patients With Neuroendocrine Tumor
Feasibility of Low-Dose 68Ga-DOTATATE With Short Acquisition Time Using Total-Body PET/CT in Patients With Neuroendocrine Tumor Open
Purpose To explore the feasibility of a low dose regimen with short acquisition time of 68 Ga-DOTATATE total-body PET/CT without compromising image quality of patients with NETs. Methods Fifty-seven consecutive NETs patients who underwent …
View article: Gadolinium-Based Nanoparticles for Theranostic MRI-Guided Radiosensitization in Hepatocellular Carcinoma
Gadolinium-Based Nanoparticles for Theranostic MRI-Guided Radiosensitization in Hepatocellular Carcinoma Open
Background: Radiation therapy (RT) of hepatocellular carcinoma (HCC) is limited by low tolerance of the liver to radiation, whereas radiosensitizers are effective in reducing the required radiation dose. Multimodality gadolinium-based nano…
View article: Treatment of Hepatocellular Carcinoma by Intratumoral Injection of 125I-AA98 mAb and Its Efficacy Assessments by Molecular Imaging
Treatment of Hepatocellular Carcinoma by Intratumoral Injection of 125I-AA98 mAb and Its Efficacy Assessments by Molecular Imaging Open
Objective: To investigate the therapeutic efficacy of intratumoral injection of 125I-AA98 mAb for hepatocellular carcinoma (HCC) and its therapy efficacy assessment by 99mTc-HYNIC-duramycin and 99mTc-HYNIC-3PRGD2 SPECT/CT imaging. Methods:…
View article: Pretargeted Nuclear Imaging and Radioimmunotherapy Based on the Inverse Electron-Demand Diels–Alder Reaction and Key Factors in the Pretargeted Synthetic Design
Pretargeted Nuclear Imaging and Radioimmunotherapy Based on the Inverse Electron-Demand Diels–Alder Reaction and Key Factors in the Pretargeted Synthetic Design Open
The exceptional speed and biorthogonality of the inverse electron-demand Diels–Alder (IEDDA) click chemistry between 1,2,4,5-tetrazines and strained alkene dienophiles have made it promising in the realm of pretargeted imaging and therapy.…
View article: Evaluation of EGFR-TK Expression with a <sup>99m</sup> Tc-Labeled Complex Bearing Quinazoline Pharmacophore
Evaluation of EGFR-TK Expression with a <sup>99m</sup> Tc-Labeled Complex Bearing Quinazoline Pharmacophore Open
Objectives: The epidermal growth factor receptor (EGFR) signaling pathway is widely recognized to play an important role in development and progression of many malignant tumors, including lung cancer. The aim of this study was to produce a…
View article: P2X7 PET Radioligand <sup>18</sup>F-PTTP for Differentiation of Lung Tumor from Inflammation
P2X7 PET Radioligand <sup>18</sup>F-PTTP for Differentiation of Lung Tumor from Inflammation Open
Site-specific imaging agents play a key role in tumor targeting, but only a few agents are currently available for inflammation targeting. Since the P2X7 receptor (P2X7R) is a promising molecular target for inflammation, we evaluated the p…
View article: Decreased vesicular acetylcholine transporter related to memory deficits in epilepsy: A [<sup>18</sup>F] VAT positron emission tomography brain imaging study
Decreased vesicular acetylcholine transporter related to memory deficits in epilepsy: A [<sup>18</sup>F] VAT positron emission tomography brain imaging study Open
Summary Objective Vesicular acetylcholine transporter ( VAC hT) is a rate‐limiting factor for synaptic acetylcholine transport. Our study focused on whether [ 18 F] VAT , a novel positron emission tomography ( PET ) tracer, could be used i…
View article: A Novel Ideal Radionuclide Imaging System for Non-invasively Cell Monitoring built on Baculovirus Backbone by Introducing Sleeping Beauty Transposon
A Novel Ideal Radionuclide Imaging System for Non-invasively Cell Monitoring built on Baculovirus Backbone by Introducing Sleeping Beauty Transposon Open
Sleeping Beauty (SB) transposon is an attractive tool in stable transgene integration both in vitro and in vivo ; and we introduced SB transposon into recombinant sodium-iodide symporter baculovirus system (Bac-NIS system) to facilitate lo…
View article: Radiosynthesis and pharmacokinetics of [<sup>18</sup>F]fluoroethyl bufalin in hepatocellular carcinoma-bearing mice
Radiosynthesis and pharmacokinetics of [<sup>18</sup>F]fluoroethyl bufalin in hepatocellular carcinoma-bearing mice Open
[18F]fluoroethyl bufalin was accumulated rapidly in the liver at an early time point (5 min) post injection (pi) and then declined slowly, mainly through both the hepatic pathway and the renal pathway. Our study showed the biodistribution …
View article: Re-188 Enhances the Inhibitory Effect of Bevacizumab in Non-Small-Cell Lung Cancer
Re-188 Enhances the Inhibitory Effect of Bevacizumab in Non-Small-Cell Lung Cancer Open
The malignant behaviors of solid tumors such as growth, infiltration and metastasis are mainly nourished by tumor neovascularization. Thus, anti-angiogenic therapy is key to controlling tumor progression. Bevacizumab, a humanized anti-vasc…