Explanipedia

Maternal obesity impairs fetal brown adipogenesis by attenuating fetal FGF21 signaling Open

Lun Hua, Wen Shen, Dengfeng Gao, Yi Yang, Xiaohan Yang , et al. · 2025

Impact of self-reported SARS-CoV-2 antibody positivity on cardiac structure and function: findings from UK Biobank CMR cohort Open

Chang Liu, Yao Ma, Shiyuan Qiao, Kexin Li, Mengyao Qi , et al. · 2025

Background SARS-CoV-2 antibody positivity, whether due to natural infection or vaccination, is known to be associated with specific cardiac and vascular damage, yet its impact on cardiac structure and function in prospective cohorts remain…

The relationship between complement C1q and coronary plaque vulnerability based on optical coherence tomography analysis Open

Yuan Wang, Jiawei Zheng, Qing Li, Yao Ma, Chang Liu , et al. · 2024

To determine the association between complement C1q and vulnerable plaque morphology among coronary artery disease (CAD) patients. We conducted a retrospective observational study of 221 CAD patients admitted to The Second Affiliated Hospi…

The role of cardiac remodeling associated with renal function in mediating cardiovascular event outcomes Open

Zhi Lv, Yangzhi Fu, Chang Liu, Yao Ma, Yuan Miao , et al. · 2024

The potential impact of renal function-related cardiovascular remodeling on associated cardiovascular risk has not been previously investigated. Hence, we conducted multiple mediation analyses in the UK Biobank study to evaluate this assoc…

Sodium intake and the risk of heart failure and hypertension: epidemiological and Mendelian randomization analysis Open

Yuan Miao, Dingyi Yan, Yu Wang, Mengyao Qi, Kexin Li , et al. · 2024

Background This study aimed to analysis the relationship between sodium intake and the risk of heart failure and hypertension through epidemiological studies and Mendelian randomization analysis. Methods and result We initially conducted a…

Sk-Conv and SPP-based UNet for lesion segmentation of coronary optical coherence tomography Open

Zhan Wang, Jiawei Zheng, Peilin Jiang, Dengfeng Gao · 2023

BACKGROUND: Coronary artery disease (CAD) manifests with a blockage the coronary arteries, usually due to plaque buildup, and has a serious impact on the human life. Atherosclerotic plaques, including fibrous plaques, lipid plaques, and ca…

Conventional and genetic associations between resting heart rate, cardiac morphology and function as assessed by magnetic resonance imaging: Insights from the UK biobank population study Open

Yao Ma, Mengyao Qi, Kexin Li, Yuan Wang, Fuxian Ren , et al. · 2023

Aim To examine the direction, strength and causality of the associations of resting heart rate (RHR) with cardiac morphology and function in 20,062 UK Biobank participants. Methods and results Participants underwent cardiac magnetic resona…

Development of a novel tool: a nomogram for predicting in-hospital mortality of patients in intensive care unit after percutaneous coronary intervention Open

Yuan Miao, Bin Cheng Ren, Yu Wang, Fuxian Ren, Dengfeng Gao · 2023

Development of a complete blood count with differential—based prediction model for in-hospital mortality among patients with acute myocardial infarction in the coronary care unit Open

Yu Wang, Changfu Li, Yuan Miao, Bincheng Ren, Chang Liu , et al. · 2022

Purpose In recent years, the complete blood count with differential (CBC w/diff) test has drawn strong interest because of its prognostic value in cardiovascular diseases. We aimed to develop a CBC w/diff-based prediction model for in-hosp…

Assessing potassium levels in critically ill patients with heart failure: application of a group‐based trajectory model Open

Zehao Lin, Jiawei Zheng, Xiaochun Liu, Xiaojun Hu, Fuxian Ren , et al. · 2022

Aims Abnormalities in potassium homeostasis are frequently seen in hospitalized patients. A poor outcome in heart failure (HF) has been linked to both hypokalaemia and hyperkalaemia. The studies on the connection between variations in pota…

A TWO-STAGE EXTRACTION NETWORK FOR THE OPTICAL COHERENCE TOMOGRAPHY CONTOUR Open

Xinyu Cao, Peilin Jiang, Dengfeng Gao · 2022

Optical coherence tomography (OCT) with high resolution was found lucrative for coronary heart disease diagnosis and treatment such as evaluating the degree of vascular stenosis and guiding stent implantation. Lumen contour is an essential…

Qualitative and Quantitative Analysis of Ejiao-Related Animal Gelatins through Peptide Markers Using LC-QTOF-MS/MS and Scheduled Multiple Reaction Monitoring (MRM) by LC-QQQ-MS/MS Open

Wenjie Wu, Lifeng Li, Hau-Yee Fung, Huiyuan Cheng, Hau‐Yee Kong , et al. · 2022

Donkey-hide gelatin, also called Ejiao (colla corii asini), is commonly used as a food health supplement and valuable Chinese medicine. Its growing popular demand and short supply make it a target for fraud, and many other animal gelatins …

The Value of SII in Predicting the Mortality of Patients with Heart Failure Open

Yuan Miao, Fuxian Ren, Dengfeng Gao · 2022

Background. The main purpose of this study was to explore the predictive value of the systemic immune inflammation index (SII), a novel clinical marker, in heart failure (HF) patients. Methods. Critically ill patients with HF were identifi…

The Admission (Neutrophil+Monocyte)/Lymphocyte Ratio Is an Independent Predictor for In-Hospital Mortality in Patients With Acute Myocardial Infarction Open

Yu Wang, Yuan Miao, Yao Ma, Congcong Shao, Yuan Wang , et al. · 2022

Purpose Peripheral differential leukocyte counts are accepted prognostic indicators in patients with acute myocardial infarction (AMI). Herein, we assessed the value of the admission (neutrophil+monocyte)/lymphocyte ratio (NMLR) in predict…

Hub Targets Analysis of miRNA-mRNA-TF Network in Diabetic Cardiomyopathy Open

Bincheng Ren, Kaini He, Yuan Miao, Yu Wang, Yuanyuan Tie , et al. · 2021

Background : The pathogenic mechanism and development of the diabetic cardiomyopathy(DCM) has been generally explained, and it is clear that the microRNAs(miRNAs), mRNAs and transcription factors(TFs) participate in the process of the DCM …

Efficacy and Safety of Ejiao (Asini Corii Colla) in Women With Blood Deficient Symptoms: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial Open

Li Zhang, Xu Zhongju, Tao Jiang, Jialu Zhang, Pinxian Huang , et al. · 2021

Equus asinus L [Equidae; Asini Corii Colla] (donkey-hide gelatin, Ejiao), a well-known traditional Chinese medicine, has been widely used to nourish the blood, especially for women. The aim of this study was to assess the efficacy and safe…

Role of PCSK9 in Homocysteine-Accelerated Lipid Accumulation in Macrophages and Atherosclerosis in ApoE−/− Mice Open

Ping Jin, Dengfeng Gao, Guangzhi Cong, Ru Yan, Shaobin Jia · 2021

Background: Homocysteine (Hcy) has been established as an independent risk factor for atherosclerosis, and the involvement of hyperhomocysteinemia (HHcy) in atherosclerotic lesions is complex. Proprotein convertase subtilisin kexin 9 (PCSK…

rGO/Silk Fibroin-Modified Nanofibrous Patches Prevent Ventricular Remodeling via Yap/Taz-TGFβ1/Smads Signaling After Myocardial Infarction in Rats Open

Yanjing Feng, Guoxu Zhao, Min Xu, Xin Xing, Lijun Yang , et al. · 2021

Objective: After acute myocardial infarction (AMI), the loss of cardiomyocytes and dysregulation of extracellular matrix homeostasis results in impaired cardiac function and eventually heart failure. Cardiac patches have emerged as a poten…

The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study Open

Dengfeng Gao, Min Xu, Gang Wang, Jianrui Lv, Xiaorong Ma , et al. · 2021

High-dose vitamin C may reduce the mortality and improve oxygen support status in patients with Coronavirus disease 2019 without adverse events.

Increased levels of ferritin on admission predicts intensive care unit mortality in patients with COVID-19 Open

Fuxue Deng, Lisha Zhang, Lyu Lyu, Ziwei Lu, Dengfeng Gao , et al. · 2020

MicroRNA‐26a Protects the Heart Against Hypertension‐Induced Myocardial Fibrosis Open

Wenqian Zhang, Qiaozhu Wang, Yanjing Feng, Xuegui Chen, Lijun Yang , et al. · 2020

Background Hypertensive myocardial fibrosis (MF) is characterized by excessive deposition of extracellular matrix and cardiac fibroblast proliferation, which can lead to heart failure, malignant arrhythmia, and sudden death. In recent year…

The antagonistic effects and mechanisms of microRNA-26a action in hypertensive vascular remodeling Open

Wenqian Zhang, Qiaozhu Wang, Xin Xing, Lijun Yang, Min Xu , et al. · 2020

Background and Purpose: Hypertensive vascular remodeling (VR) is responsible for end-organ damage and is the result of increased extracellular matrix accumulation and excessive vascular smooth muscle cell (VSMC) proliferation. MicroRNA-26a…

Corticosteroids in diabetes patients infected with COVID-19 Open

Fuxue Deng, Dengfeng Gao, Xiaorong Ma, Yonghong Guo, Rong Wang , et al. · 2020

MicroRNA-26a Protects the Heart Against Hypertension-Induced Ventricular Remodeling Open

Wenqian Zhang, Qiaozhu Wang, Yanjing Feng, Xuegui Chen, Lijun Yang , et al. · 2019

Integrated analysis of microRNA and mRNA expression profiles in rats with selenium deficiency and identification of associated miRNA-mRNA network Open

Yanjing Feng, Yunjie Xing, Zhongwei Liu, Guang Yang, Xiaolin Niu , et al. · 2018

Mechanism of Clustering Transportation for Projectiles Mixed Storage in Magazines Open

Zhang Jian-bin, Yiyuan Chen, Dengfeng Gao · 2018

To focus on the problems of low transport efficiency, poor ship-borne suitability of the present large and medium caliber naval guns, utilizing information correlation and integration technology, this paper put forward and built the decisi…

A case report and literature review of Churg–Strauss syndrome presenting with myocarditis Open

Lu Qiao, Dengfeng Gao · 2016

By reviewing the present case reports, we concluded that (1) the younger age of CSS, the greater occurrence rate of complicating myocarditis and the poorer prognosis; (2) female CSS patients are older than male patients; (3) patients with …

Age-related changes in hypertensive brain damage in the hippocampi of spontaneously hypertensive rats Open

Yali Li, Jian Liu, Dengfeng Gao, Jin Wei, Haifeng Yuan , et al. · 2016

The aim of the present study was to investigate the age‑related alterations in hypertensive brain damage in the hippocampi of spontaneously hypertensive rats (SHR) and the underlying mechanisms. Aging resulted in a significant increase in …

CCDC 1443664: Experimental Crystal Structure Determination Open

Li Guan, Anyang Li, Yinyin Song, Mengqi Yan, Dengfeng Gao , et al. · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1443661: Experimental Crystal Structure Determination Open

Li Guan, Anyang Li, Yinyin Song, Mengqi Yan, Dengfeng Gao , et al. · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

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