Explanipedia

Protein arginine methyltransferase 1 stimulates basal cell proliferation and migration to maintain corneal epithelial homeostasis Open

Jia Yang, Mingzheng Hu, Mulin Yang, Hua Ni, Jun Zhou , et al. · 2025

Coordination of IFT20 With Other IFT Components Is Required for Ciliogenesis Open

W. Wang, Ying Chun Shan, Ruming Liu, Dengwen Li, Jun Zhou , et al. · 2025

Background Primary cilia are organelles formed on the cell surface. They can act as cellular antennae to sense signals and play important roles in various biological processes. Abnormalities in primary cilia lead to a variety of diseases c…

UFMylation Modulates OFIP Stability and Centrosomal Localization Open

Mulin Yang, Zhiyang Zhao, Jie Di, Dan Dong, Dengwen Li , et al. · 2025

Background OFIP, also known as KIAA0753, is a centrosomal and pericentriolar satellite protein implicated in ciliogenesis, centriolar duplication, and microtubule stability. In humans, genetic mutations affecting OFIP have been implicated …

CYLD Maintains Retinal Homeostasis by Deubiquitinating ENKD1 and Promoting the Phagocytosis of Photoreceptor Outer Segments Open

Song Yang, Yu Fan, Mulin Yang, Hua Ni, Weiwen Bu , et al. · 2024

Phagocytosis of shed photoreceptor outer segments by the retinal pigment epithelium (RPE) is essential for retinal homeostasis. Dysregulation of the phagocytotic process is associated with irreversible retinal degenerative diseases. Howeve…

CYLD/HDAC6 signaling regulates the interplay between epithelial-mesenchymal transition and ciliary homeostasis during pulmonary fibrosis Open

Hua Ni, Miao Chen, Dan Dong, Yunqiang Zhou, Yu Cao , et al. · 2024

The primary cilium behaves as a platform for sensing and integrating extracellular cues to control a plethora of cellular activities. However, the functional interaction of this sensory organelle with epithelial-mesenchymal transition (EMT…

KIF11 UFMylation Maintains Photoreceptor Cilium Integrity and Retinal Homeostasis Open

Jie Ran, Guizhi Guo, Sai Zhang, Yufei Zhang, Liang Zhang , et al. · 2024

The photoreceptor cilium is vital for maintaining the structure and function of the retina. However, the molecular mechanisms underlying the photoreceptor cilium integrity and retinal homeostasis are largely unknown. Herein, it is shown th…

High LGALS3 expression induced by HCP5/hsa-miR-27b-3p correlates with poor prognosis and tumor immune infiltration in hepatocellular carcinoma Open

Yinghui Ren, Yongmei Qian, Qicheng Zhang, Xiaoping Li, Mingjiang Li , et al. · 2024

XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis Open

Renjie Hong, Yanjie Tan, Xiaoyu Tian, Zhenzhou Huang, Jiaying Wang , et al. · 2024

Activation of hepatic stellate cells (HSCs) plays a critical role in liver fibrosis. However, the molecular basis for HSC activation remains poorly understood. Herein, we demonstrate that primary cilia are present on quiescent HSCs but exh…

Pathologically relevant aldoses and environmental aldehydes cause cilium disassembly via formyl group-mediated mechanisms Open

Te Li, Min Liu, Yu Fan, Song Yang, Weiwen Bu , et al. · 2023

Carbohydrate metabolism disorders (CMDs), such as diabetes, galactosemia, and mannosidosis, cause ciliopathy-like multiorgan defects. However, the mechanistic link of cilia to CMD complications is still poorly understood. Herein, we descri…

O‐GlcNAcylation Regulates Centrosome Behavior and Cell Polarity to Reduce Pulmonary Fibrosis and Maintain the Epithelial Phenotype Open

Yu Fan, Song Yang, Hua Ni, Heng Dai, Xuemei Wu , et al. · 2023

O ‐GlcNAcylation functions as a cellular nutrient and stress sensor and participates in almost all cellular processes. However, it remains unclear whether O ‐GlcNAcylation plays a role in the establishment and maintenance of cell polarity,…

HDAC6 deacetylates IDH1 to promote the homeostasis of hematopoietic stem and progenitor cells Open

Jia Yang, Yang Liu, Hanxiao Yin, Songbo Xie, Linlin Zhang , et al. · 2023

CYLD deubiquitinates plakoglobin to promote Cx43 membrane targeting and gap junction assembly in the heart Open

Wei Xie, Siqi Gao, Yunfan Yang, Kai Li, Junyan Zhou , et al. · 2022

During heart maturation, gap junctions assemble into hemichannels and polarize to the intercalated disc at cell borders to mediate electrical impulse conduction. However, the molecular mechanism underpinning cardiac gap junction assembly r…

Targeting the HDAC6‐Cilium Axis Ameliorates the Pathological Changes Associated with Retinopathy of Prematurity Open

Jie Ran, Yao Zhang, Sai Zhang, Haixia Li, Liang Zhang , et al. · 2022

Retinopathy of prematurity (ROP) is one of the leading causes of childhood visual impairment and blindness. However, there are still very few effective pharmacological interventions for ROP. Histone deacetylase 6 (HDAC6)‐mediated disassemb…

ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis Open

Ting Song, Yunfan Yang, Peng Zhou, Jie Ran, Liang Zhang , et al. · 2022

ENKD1 promotes epidermal stratification by regulating spindle orientation in basal keratinocytes Open

Tao Zhong, Xiaofan Wu, Wei Xie, Xiangrui Luo, Ting Song , et al. · 2022

Functions and Diseases of the Retinal Pigment Epithelium Open

Song Yang, Jun Zhou, Dengwen Li · 2021

The retinal pigment epithelium is a fundamental component of the retina that plays essential roles in visual functions. Damage to the structure and function of the retinal pigment epithelium leads to a variety of retinopathies, and there i…

Potential role for the tumor suppressor CYLD in brain and notochord development Open

Te Li, Yiyan Wang, Dengwen Li, Jun Zhou, Bo Zhang , et al. · 2021

Background The cylindromatosis (CYLD) tumor suppressor is a microtubule‐associated deubiquitinase that plays a critical role in the regulation of cell signaling and contributes to a variety of physiological and pathological processes. Howe…

CYLD deficiency causes auditory neuropathy due to reduced neurite outgrowth Open

Song Yang, Nan Ma, Xuemei Wu, Hua Ni, Siqi Gao , et al. · 2021

Background Auditory neuropathy is a cause of hearing loss that has been studied in a number of animal models. Signal transmission from hair cells to spiral ganglion neurons plays an important role in normal hearing. CYLD is a microtubule‐b…

New Insights Into Functions of IQ67-Domain Proteins Open

Chunyue Guo, Jun Zhou, Dengwen Li · 2021

IQ67-domain (IQD) proteins, first identified in Arabidopsis and rice, are plant-specific calmodulin-binding proteins containing highly conserved motifs. They play a critical role in plant defenses, organ development and shape, and drought …

HIV-1 exposure promotes PKG1-mediated phosphorylation and degradation of stathmin to increase epithelial barrier permeability Open

Wei Xie, Mingzhen Chen, Zhaodong Zhai, Hongjie Li, Ting Song , et al. · 2021

Orientation of the Mitotic Spindle in Blood Vessel Development Open

Xuemei Wu, Jun Zhou, Dengwen Li · 2020

Angiogenesis requires coordinated endothelial cell specification, proliferation, and collective migration. The orientation of endothelial cell division is tightly regulated during the earliest stages of blood vessel formation in response t…

HDAC6 regulates antibody-dependent intracellular neutralization of viruses via deacetylation of TRIM21 Open

Songbo Xie, Linlin Zhang, Dan Dong, Ruixin Ge, Qianqian He , et al. · 2020

Tripartite motif-containing protein 21 (TRIM21) is a cytosolic antibody receptor that targets the internalized virus-antibody complex to the proteasome for degradation. However, the precise mechanism regulating TRIM21 activity is unknown. …

O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis Open

Fan Yu, Te Li, Yanchao Sui, Qingxia Chen, Song Yang , et al. · 2020

O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis

Histone Deacetylase 6 as a Therapeutic Target in B cell-associated Hematological Malignancies Open

Jia Yang, Dengwen Li, Jun Zhou · 2020

B lymphocytes play a critical role in humoral immunity. Abnormal B cell development and function cause a variety of hematological malignancies such as myeloma, B cell lymphoma, and leukemia. Histone deacetylase 6 (HDAC6) inhibitors alone o…

HIV-1 exposure triggers autophagic degradation of stathmin and hyperstabilization of microtubules to disrupt epithelial cell junctions Open

Wei Xie, Dengwen Li, Dan Dong, Yuanyuan Li, You Zhang , et al. · 2020

Microtubule-Associated Protein Mdp3 Promotes Breast Cancer Growth and Metastasis: Erratum Open

Tala, Songbo Xie, Xiaodong Sun, Xiaoou Sun, Jie Ran , et al. · 2020

[This corrects the article DOI: 10.7150/thno.9727.].

Mixed-lineage leukemia protein 2 suppresses ciliary assembly by the modulation of actin dynamics and vesicle transport Open

Yang Yang, Huijie Hao, Xiaofan Wu, Song Guo, Yang Liu , et al. · 2019

Primary cilia are critically involved in the coordination of diverse signaling pathways and ciliary defects are associated with a variety of human diseases. The past decades have witnessed great progress in the core machinery orchestrating…

Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications Open

Fan Yu, Song Guo, Te Li, Jie Ran, Wei Zhao , et al. · 2018

Exopolysaccharides from a Codonopsis pilosula endophyte activate macrophages and inhibit cancer cell proliferation and migration Open

Min Chen, Yuanyuan Li, Zhu Liu, Yajun Qu, Huajie Zhang , et al. · 2018

Background Exopolysaccharides with structural diversity have shown wide applications in biomaterial, food, and pharmaceutical industries. Herein, we isolated an endophytic strain, 14‐DS‐1, from the traditional medicinal plant Codonopsis pi…

Histone deacetylase 6 modulates macrophage infiltration during inflammation Open

Bing Yan, Songbo Xie, Yang Liu, Wenxuan Liu, Dengwen Li , et al. · 2018

Mice with histone deacetylase 6 (HDAC6) deficiency grow and develop normally but exhibit impaired immune response. The molecular mechanisms for this phenotype remain largely elusive. Methods: A mouse acute peritonitis model was used…

Dengwen Li YOU? Author Swipe