Denis Blanchet
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View article: High Genetic Diversity of <i>Histoplasma</i> in the Amazon Basin, 2006–2017
High Genetic Diversity of <i>Histoplasma</i> in the Amazon Basin, 2006–2017 Open
Histoplasmosis is one of the most common pulmonary mycosis diseases in the world. Genome sequencing has revealed that Histoplasma, the cause of histoplasmosis, is composed of several phylogenetic species. The genetic diversity of the patho…
View article: High genetic diversity of<i>Histoplasma</i>in the Amazon basin, 2006-2017
High genetic diversity of<i>Histoplasma</i>in the Amazon basin, 2006-2017 Open
Genome sequencing has revealed that Histoplasma , the etiological agent of histoplasmosis is composed of several phylogenetic species. Nonetheless, the genetic diversity of the pathogen remains largely unknown, especially in the tropics. W…
View article: Molecular epidemiology of<i>Candida africana</i>isolates collected from vagina swabs in French Guiana
Molecular epidemiology of<i>Candida africana</i>isolates collected from vagina swabs in French Guiana Open
Candida africana corresponds to the clade 13 of Candia albicans . It has been mostly involved in vulvovaginal candidiasis worldwide but few data exist in South America. The aim of our study was to investigate the prevalence of C. africana …
View article: Pulmonary Histoplasmosis in People Living with Human Immunodeficiency Virus in French Guiana: Clinical Epidemiology, Medical Imaging and Prognostic
Pulmonary Histoplasmosis in People Living with Human Immunodeficiency Virus in French Guiana: Clinical Epidemiology, Medical Imaging and Prognostic Open
Background Histoplasmosis is mainly described as a disseminated disease in people living with HIV (PLHIV). Compared to historical descriptions in immunocompetent individuals, knowledge is lacking on the detailed clinical and radiological f…
View article: Morphological and Molecular Characterizations of Cochliomyia hominivorax (Diptera: Calliphoridae) Larvae Responsible for Wound Myiasis in French Guiana
Morphological and Molecular Characterizations of Cochliomyia hominivorax (Diptera: Calliphoridae) Larvae Responsible for Wound Myiasis in French Guiana Open
Myiasis is an ectoparasitic infection caused by the larvae of true flies (Diptera). We came across a rather rare case of myiasis in an immunocompetent 34-year-old man from French Guiana with advanced wound myiasis masquerading as cavitary …
View article: Yellow Fever Reemergence Risk in the Guiana Shield: a Comprehensive Review of Cases Between 1990 and 2022
Yellow Fever Reemergence Risk in the Guiana Shield: a Comprehensive Review of Cases Between 1990 and 2022 Open
View article: Case Report: Acute Brucellosis Due to Brucella suis in a Brazilian Gold Miner Diagnosed in French Guiana
Case Report: Acute Brucellosis Due to Brucella suis in a Brazilian Gold Miner Diagnosed in French Guiana Open
A 29-year-old Brazilian illegal gold miner developed intermittent fever. Blood cultures were positive for Gram-negative coccobacilli and, after an initial misidentification by an automated identification system, the diagnosis of brucellosi…
View article: Dynamics of SARS-CoV-2 lineages in French Guiana in 2020–2021: 4 epidemic waves with cross-influences from Europe and South America
Dynamics of SARS-CoV-2 lineages in French Guiana in 2020–2021: 4 epidemic waves with cross-influences from Europe and South America Open
View article: Novel Chronic Anaplasmosis in Splenectomized Patient, Amazon Rainforest
Novel Chronic Anaplasmosis in Splenectomized Patient, Amazon Rainforest Open
We report a case of unusual human anaplasmosis in the Amazon rainforest of French Guiana. Molecular typing demonstrated that the pathogen is a novel Anaplasma species, distinct to all known species, and more genetically related to recently…
View article: Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018)
Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018) Open
The epidemiology of invasive fungal diseases (IFDs) is hard to delineate given the difficulties in ascertaining the diagnosis that is often based on the confrontation of clinical and microbiological criteria. The present report underlines …
View article: Case Report: Invasive Cryptococcosis in French Guiana: Immune and Genetic Investigation in Six Non-HIV Patients
Case Report: Invasive Cryptococcosis in French Guiana: Immune and Genetic Investigation in Six Non-HIV Patients Open
Objectives We describe the clinical, mycological, immunological, and genetic characteristics of six HIV-negative patients presenting with invasive cryptococcosis. Methods Patients with cryptococcosis without any of the classical risk facto…
View article: Cryptosporidiosis outbreak in Amazonia, French Guiana, 2018
Cryptosporidiosis outbreak in Amazonia, French Guiana, 2018 Open
Background Cryptosporidiosis outbreaks in South America are poorly documented. In March 2018, 51 cases of cryptosporidiosis were reported in Maripasoula, a village located in a remote forest area along the border between Surinam and French…
View article: Chemosensory Gene Expression for Two Closely Relative Species Rhodnius robustus and R. prolixus (Hemiptera, Reduviidade, Triatominae) Vectors of Chagas Disease
Chemosensory Gene Expression for Two Closely Relative Species Rhodnius robustus and R. prolixus (Hemiptera, Reduviidade, Triatominae) Vectors of Chagas Disease Open
Two closely related species, Rhodnius prolixus and Rhodnius robustus , are the vectors of Trypanosoma cruzi , which is the causative agent of Chagas disease, but clearly exhibit clear-cut differences in their ecological behavior. R. prolix…
View article: Breakthrough Infections of SARS-CoV-2 Gamma Variant in Fully Vaccinated Gold Miners, French Guiana, 2021
Breakthrough Infections of SARS-CoV-2 Gamma Variant in Fully Vaccinated Gold Miners, French Guiana, 2021 Open
An outbreak of severe acute respiratory syndrome coronavirus 2 caused by the Gamma variant of concern infected 24/44 (55%) employees of a gold mine in French Guiana (87% symptomatic, no severe forms). The attack rate was 60% (15/25) among …
View article: Accuracy of SD Malaria Ag P.f/Pan® as a rapid diagnostic test in French Amazonia
Accuracy of SD Malaria Ag P.f/Pan® as a rapid diagnostic test in French Amazonia Open
View article: Diagnostic accuracy and acceptability of molecular diagnosis of COVID-19 on saliva samples relative to nasopharyngeal swabs in tropical hospital and extra-hospital contexts: The COVISAL study
Diagnostic accuracy and acceptability of molecular diagnosis of COVID-19 on saliva samples relative to nasopharyngeal swabs in tropical hospital and extra-hospital contexts: The COVISAL study Open
A prospective study was conducted among different intra and extra-hospital populations of French Guiana to evaluate the performance of saliva testing compared to nasopharyngeal swabs. Persons aged 3 years and older with mild symptoms sugge…
View article: Review of diagnostic methods and results for HIV‐associated disseminated histoplasmosis: Pathologists are not sufficiently involved
Review of diagnostic methods and results for HIV‐associated disseminated histoplasmosis: Pathologists are not sufficiently involved Open
Objectives Disseminated histoplasmosis is a major killer of HIV‐infected persons in Latin America. Antigen detection, fungal culture and Polymerase Chain Reaction are often not available, but cytology and histology are present in most hosp…
View article: Cytological Spectrum of Pulmonary Histoplasmosis Diagnosed by Bronchoalveolar Lavage: 12 Years of Experience in French Guiana
Cytological Spectrum of Pulmonary Histoplasmosis Diagnosed by Bronchoalveolar Lavage: 12 Years of Experience in French Guiana Open
Disseminated histoplasmosis is a major cause of mortality in HIV-infected patients. Rapid and efficient diagnosis of Histoplasma capsulatum is crucial. Cytopathology is available in most hospitals and represents a rapid diagnostic alternat…
View article: Invasive Fungal Infections in Persons Living with HIV in an Amazonian Context: French Guiana, 2009–2019
Invasive Fungal Infections in Persons Living with HIV in an Amazonian Context: French Guiana, 2009–2019 Open
Although the burden of histoplasmosis in patients with advanced HIV has been the focus of detailed estimations, knowledge about invasive fungal infections in patients living with HIV in an Amazonian context is somewhat scattered. Our goal …
View article: Histoplasmosis of the Central Nervous System: A Case Series between 1990 and 2019 in French Guiana
Histoplasmosis of the Central Nervous System: A Case Series between 1990 and 2019 in French Guiana Open
Disseminated histoplasmosis is the most frequent acquired immunodeficiency syndrome–defining illness in French Guiana. Paradoxically, central nervous system (CNS) involvement has been scarcely described. We aimed to identify CNS histoplasm…
View article: Accuracy of SD Malaria Ag P.f/Pan® As A Rapid Diagnosis Test of Malaria in French Amazonia
Accuracy of SD Malaria Ag P.f/Pan® As A Rapid Diagnosis Test of Malaria in French Amazonia Open
BackgroundFrench Guiana (FG) is, with Mayotte island, one of the two French overseas territories where malaria is still endemic. Ten years ago, French health authorities implemented a strategy to eradicate malaria disease in the region. Th…
View article: Immunoblot for the Diagnosis of Cutaneous Leishmaniasis in French Guiana
Immunoblot for the Diagnosis of Cutaneous Leishmaniasis in French Guiana Open
Cutaneous leishmaniasis (CL) is firmly established in South America. We aimed to assess the detection of IgG antibodies against 14 and/or 16 kDa antigens by immunoblot (IB) for CL serological diagnosis in French Guiana, an area where many …
View article: HIV-Associated Disseminated Histoplasmosis and Rare Adrenal Involvement: Evidence of Absence or Absence of Evidence
HIV-Associated Disseminated Histoplasmosis and Rare Adrenal Involvement: Evidence of Absence or Absence of Evidence Open
Adrenal histoplasmosis and primary adrenal insufficiency are mostly described in immunocompetent patients. This particular tropism is attributed to the presence of cortisol within the adrenal gland, a privileged niche for Histoplasma growt…
View article: Prospective Comparison of Saliva and Nasopharyngeal Swab Sampling for Mass Screening for COVID-19
Prospective Comparison of Saliva and Nasopharyngeal Swab Sampling for Mass Screening for COVID-19 Open
Current testing for COVID-19 relies on reverse-transcriptase polymerase chain reaction from a nasopharyngeal swab specimen. Saliva samples have advantages regarding ease and painlessness of collection, which does not require trained staff …
View article: Prevalence of intestinal parasite among patients attending two hospitals in French Guiana: A 6-year retrospective study
Prevalence of intestinal parasite among patients attending two hospitals in French Guiana: A 6-year retrospective study Open
Introduction Intestinal parasitic diseases are a global health problem. Due to its equatorial climate, vast territory with isolated areas and the precariousness of its population, intestinal parasitosis is considered to be a major issue in…
View article: Validation of Swab Sampling and SYBR Green-Based Real-Time PCR for the Diagnosis of Cutaneous Leishmaniasis in French Guiana
Validation of Swab Sampling and SYBR Green-Based Real-Time PCR for the Diagnosis of Cutaneous Leishmaniasis in French Guiana Open
Recent studies have highlighted the interest in noninvasive sampling procedures coupled with real-time PCR methods for the detection of Leishmania species in South America. In French Guiana, the sampling method still relied on skin biopsie…
View article: Cytological and Histopathological Spectrum of Histoplasmosis: 15 Years of Experience in French Guiana
Cytological and Histopathological Spectrum of Histoplasmosis: 15 Years of Experience in French Guiana Open
From the pathologist perspective, this is the largest series to date showing that digestive involvement was the most frequent, usually with a tuberculoid form and a greater load of Histoplasma. With awareness and expertise, cytology…
View article: A Review of Diagnostic Methods and Results for HIV-associated Disseminated Histoplasmosis: Shouldn’t We be Involving Pathologists More Systematically?
A Review of Diagnostic Methods and Results for HIV-associated Disseminated Histoplasmosis: Shouldn’t We be Involving Pathologists More Systematically? Open
Background . Disseminated histoplasmosis is a major killer of HIV-infected persons in Latin America. Antigen detection, fungal culture, or Polymerase Chain Reaction are often not available, but cytology and histology are usually present in…
View article: Temporal trends of cutaneo-mucous histoplasmosis in persons living with HIV in French Guiana: Early diagnosis defuses South American strain dermotropism
Temporal trends of cutaneo-mucous histoplasmosis in persons living with HIV in French Guiana: Early diagnosis defuses South American strain dermotropism Open
Histoplasmosis is the most frequent opportunistic infection and the first cause of mortality in HIV-infected patients in French Guiana and presumably in much of Latin America. Mucocutaneous lesions of histoplasmosis are considered as rare …
View article: Hemophagocytic Lymphohistiocytosis During HIV Infection in Cayenne Hospital 2012–2015: First Think Histoplasmosis
Hemophagocytic Lymphohistiocytosis During HIV Infection in Cayenne Hospital 2012–2015: First Think Histoplasmosis Open
Introduction: Haemophagocytic Lymphohistiocytosis (HLH), during HIV infection is a rare complication with a poor prognosis. There are few data on HLH within the Amazon region. The objective was to describe epidemiological, clinical …