Denis Calise
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View article: Autonomic Nervous System Adaptation and Circadian Rhythm Disturbances of the Cardiovascular System in a Ground-Based Murine Model of Spaceflight
Autonomic Nervous System Adaptation and Circadian Rhythm Disturbances of the Cardiovascular System in a Ground-Based Murine Model of Spaceflight Open
Whether in real or simulated microgravity, Humans or animals, the kinetics of cardiovascular adaptation and its regulation by the autonomic nervous system (ANS) remain controversial. In this study, we used hindlimb unloading (HU) in 10 con…
View article: Evaluation of upconverting nanoparticles towards heart theranostics
Evaluation of upconverting nanoparticles towards heart theranostics Open
Restricted and controlled drug delivery to the heart remains a challenge giving frequent off-target effects as well as limited retention of drugs in the heart. There is a need to develop and optimize tools to allow for improved design of d…
View article: A novel 3D microdevice for the in vivo capture of cancer‐associated cells
A novel 3D microdevice for the in vivo capture of cancer‐associated cells Open
Circulating tumour cells (CTCs) correlate by their number to the lethal potential of the tumour and can be characterized in terms of molecular properties. The repeated isolation of living CTCs has now appeared as an unavoidable step toward…
View article: Ephrin-B1 blocks adult cardiomyocyte proliferation and heart regeneration
Ephrin-B1 blocks adult cardiomyocyte proliferation and heart regeneration Open
Aims Deciphering the innate mechanisms governing the blockade of proliferation in adult cardiomyocytes (CMs) is challenging for mammalian heart regeneration. Despite the exit of CMs from the cell cycle during the postnatal maturation perio…
View article: Evaluation of Upconverting nanoparticles towards heart theranostics
Evaluation of Upconverting nanoparticles towards heart theranostics Open
Restricted and controlled drug delivery to the heart remains a challenge giving frequent off-target effects as well as limited retention of drugs in the heart. There is a need to develop and optimize tools to allow for improved design of d…
View article: Macrophage‐derived HMGB1 is dispensable for tissue fibrogenesis
Macrophage‐derived HMGB1 is dispensable for tissue fibrogenesis Open
Alarmins and damage‐associated molecular patterns (DAMPs) are powerful inflammatory mediators, capable of initiating and maintaining sterile inflammation during acute or chronic tissue injury. Recent evidence suggests that alarmins/DAMPs m…
View article: Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction
Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction Open
Lymphatic endothelium serves as a barrier to control fluid balance and immune cell trafficking to maintain tissue homeostasis. Long-term alteration of lymphatic vasculature promotes edema and fibrosis, which is an aggravating factor in the…
View article: Additional file 8: of Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction
Additional file 8: of Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction Open
Molecular network predicted by IPA including miR-29b-3p and possibly related to cell death and survival and connective tissue development and function. Red = up regulated green = down regulated; all colored genes were identified in the par…
View article: Additional file 5: of Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction
Additional file 5: of Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction Open
miRNAs and their respective mRNA targets. (XLSX 12Â kb)
View article: Additional file 3: of Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction
Additional file 3: of Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction Open
Differentially expressed mRNAs in mouse partial UUO. (XLSX 44 kb)
View article: Additional file 1: of Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction
Additional file 1: of Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction Open
Differentially expressed miRNAs in human UPJ. (XLSX 15 kb)
View article: Additional file 4: of Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction
Additional file 4: of Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction Open
Common dysregulated miRNAs between human UPJ (urine) and mouse partial UUO (kidney tissue). (XLSX 9 kb)
View article: Additional file 2: of Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction
Additional file 2: of Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction Open
Differentially expressed miRNAs in mouse partial UUO. (XLSX 11 kb)
View article: Apelin‐13 administration protects against ischaemia/reperfusion‐mediated apoptosis through the FoxO1 pathway in high‐fat diet‐induced obesity
Apelin‐13 administration protects against ischaemia/reperfusion‐mediated apoptosis through the FoxO1 pathway in high‐fat diet‐induced obesity Open
Background and Purpose Apelin‐13, an endogenous ligand for the apelin (APJ) receptor, behaves as a potent modulator of metabolic and cardiovascular disorders. Here, we examined the effects of apelin‐13 on myocardial injury in a mouse model…
View article: Kinin B1 receptor antagonism is equally efficient as angiotensin receptor 1 antagonism in reducing renal fibrosis in experimental obstructive nephropathy, but is not additive
Kinin B1 receptor antagonism is equally efficient as angiotensin receptor 1 antagonism in reducing renal fibrosis in experimental obstructive nephropathy, but is not additive Open
As the B1R is induced specifically in the diseased organ and thus potentially displays low side effects it might be an interesting alternative in cases of poor tolerability to RAS inhibitors.