Denis Escobar
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View article: A decade of health research capacity building in Honduras: institutional transformation, challenges, and lessons learned
A decade of health research capacity building in Honduras: institutional transformation, challenges, and lessons learned Open
The Honduran case illustrates how targeted, multi-level investment in individuals, institutions, and governance can foster long-term research capacity in resource-constrained settings, while underscoring the need for national policies, car…
View article: Genetic diversity of Plasmodium vivax and Plasmodium falciparum field isolates from Honduras in the malaria elimination phase
Genetic diversity of Plasmodium vivax and Plasmodium falciparum field isolates from Honduras in the malaria elimination phase Open
Malaria continues to be a major threat to public health in tropical regions, primarily affecting sub-Saharan Africa but also Asia, the Middle East, and Latin America. Malaria cases in Honduras have seen a significant decline and the countr…
View article: Asymptomatic Malaria Reservoirs in Honduras: A Challenge for Elimination
Asymptomatic Malaria Reservoirs in Honduras: A Challenge for Elimination Open
Background: Efforts on a global scale for combating malaria have achieved substantial progress over the past twenty years. Two Central American nations have accomplished their goal of eliminating malaria: El Salvador and Belize. Honduras h…
View article: Asymptomatic malaria reservoirs in Honduras: a challenge for elimination
Asymptomatic malaria reservoirs in Honduras: a challenge for elimination Open
Background Efforts on a global scale for combating malaria have achieved substantial progress over the past twenty years. Two Central American nations have accomplished their goal of eliminating malaria: El Salvador and Belize. Honduras ha…
View article: Coevolutionary Analysis of the Pfs47-P47Rec Complex: A Bioinformatics Approach
Coevolutionary Analysis of the Pfs47-P47Rec Complex: A Bioinformatics Approach Open
Background: The ability to predict and comprehend molecular interactions offers significant insights into the biological functions of proteins. The interaction between surface protein 47 of Plasmodium falciparum (Pfs47) and receptor of the…
View article: Coevolutionary analysis of the Pfs47-P47Rec complex: a bioinformatics approach
Coevolutionary analysis of the Pfs47-P47Rec complex: a bioinformatics approach Open
Background : The ability to predict and comprehend molecular interactions offers significant insights into the biological functions of proteins. The interaction between Pfs47 and P47Rec has attracted increased attention due to their roles …
View article: PET-PCR reveals low parasitaemia and submicroscopic malarial infections in Honduran Moskitia
PET-PCR reveals low parasitaemia and submicroscopic malarial infections in Honduran Moskitia Open
Background Malaria remains a main parasitic disease of humans. Although the largest number of cases is reported in the African region, there are still endemic foci in the Americas. Central America reported 36,000 malaria cases in 2020, whi…
View article: PCR-RFLP assays for the identification of Anopheles (Diptera: Culicidae) species circulating in Honduras
PCR-RFLP assays for the identification of Anopheles (Diptera: Culicidae) species circulating in Honduras Open
Background Vector populations are a key target for malaria control and elimination. In Honduras there are at least 12 reported anopheline species, however, the definitive number of species remains uncertain. Due to the inherent limitations…
View article: PET-PCR reveals low parasitaemia and submicroscopic malarial infections in Honduran Moskitia
PET-PCR reveals low parasitaemia and submicroscopic malarial infections in Honduran Moskitia Open
Background: Malaria remains the main parasitic disease of humans. Although the largest number of cases is reported in the African region, there are still endemic foci in the Americas. Central America reported 36,000 malaria cases in 2020, …
View article: A PCR-RFLP Technique to Assess the Geographic Origin of Plasmodium falciparum Strains in Central America
A PCR-RFLP Technique to Assess the Geographic Origin of Plasmodium falciparum Strains in Central America Open
The elimination of malaria requires strengthening diagnosis and offering adequate and timely treatment. Imported cases of falciparum malaria represent a major challenge for pre-elimination areas, such as Central America, where chloroquine …
View article: A Follow-Up to the Geographical Distribution of Anopheles Species in Malaria-Endemic and Non-Endemic Areas of Honduras
A Follow-Up to the Geographical Distribution of Anopheles Species in Malaria-Endemic and Non-Endemic Areas of Honduras Open
Anopheles species are the vectors of malaria, one of the diseases with the greatest impact on the health of the inhabitants of the tropics. Due to their epidemiological relevance and biological complexity, monitoring of anopheline populati…
View article: Genetic Diversity among Four Populations of Aedes aegypti (Diptera: Culicidae) from Honduras as Revealed by Mitochondrial DNA Cytochrome Oxidase I
Genetic Diversity among Four Populations of Aedes aegypti (Diptera: Culicidae) from Honduras as Revealed by Mitochondrial DNA Cytochrome Oxidase I Open
Aedes aegypti is a hematophagous and highly anthropophilic mosquito with a wide distribution, particularly in tropical and subtropical regions of the world. Ae. aegypti is the main vector of several febrile diseases called arboviruses (den…
View article: Field Evaluation of a Hemozoin-Based Malaria Diagnostic Device in Puerto Lempira, Honduras
Field Evaluation of a Hemozoin-Based Malaria Diagnostic Device in Puerto Lempira, Honduras Open
The diagnosis of malaria in Honduras is based mainly on microscopic observation of the parasite in thick smears or the detection of parasite antigens through rapid diagnostic tests when microscopy is not available. The specific treatment o…
View article: A follow-up to the geographical distribution of Anopheles species in malaria- endemic and non-endemic areas of Honduras
A follow-up to the geographical distribution of Anopheles species in malaria- endemic and non-endemic areas of Honduras Open
Background: Identification of Anopheles species can be challenging, particularly in regions where cryptic complexes coexist. Due to their epidemiological relevance and biological complexity, monitoring of anopheline populations in current …
View article: Micro-Stratification for Malaria Transmission Risk in a High Burden Area of Honduras
Micro-Stratification for Malaria Transmission Risk in a High Burden Area of Honduras Open
Background As Malaria cases are continuously reported across the globe, epidemiological and integral approaches should be considered for an optimal stratification on endemic areas for elimination goal. In Central America, a 75% reduction i…
View article: Blood Meal Sources of Anopheles spp. in Malaria Endemic Areas of Honduras
Blood Meal Sources of Anopheles spp. in Malaria Endemic Areas of Honduras Open
Malaria remains a life-threatening disease in many tropical countries. Honduras has successfully reduced malaria transmission as different control methods have been applied, focusing mainly on indoor mosquitoes. The selective pressure exer…
View article: Blood Meal Sources of <i>Anopheles</i> spp. in Malaria Endemic Areas of Honduras
Blood Meal Sources of <i>Anopheles</i> spp. in Malaria Endemic Areas of Honduras Open
Malaria remains a life-threatening disease in many tropical countries. Honduras has successfully reduced malaria transmission as different control methods have been applied focusing mainly on indoor mosquitoes. The selective pressure exert…
View article: Distribution of Anopheles species in malaria endemic areas of Honduras in an elimination setting
Distribution of Anopheles species in malaria endemic areas of Honduras in an elimination setting Open
Background: Anopheles mosquitoes are the vectors of malaria, one of the most important infectious diseases in the tropics. More than 500 Anopheles species have been described worldwide, and more than 30 are considered a public health probl…
View article: The need to harmonize insecticide resistance testing: methodology, intensity concentrations and molecular mechanisms evaluated in<i>Aedes aegypti</i>populations in Central America and Hispaniola
The need to harmonize insecticide resistance testing: methodology, intensity concentrations and molecular mechanisms evaluated in<i>Aedes aegypti</i>populations in Central America and Hispaniola Open
Background The Zika AIRS Project, a USAID-funded initiative worked across the Latin America and Caribbean regions from 2016 to 2019, as an emergency to contain the spread of the Zika virus. All entomological records in the target countries…
View article: Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum
Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum Open
INTRODUCTION: Benzimidazoles are commonly used for the control of veterinary nematodes. Resistance to benzimidazoles has been associated with three single nucleotide polymorphisms in the β-tubulin gene of common nematodes. However, these m…
View article: Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum
Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum Open
This is the first report of genetic sequences associated with benzimidazole resistance in A. suum.