Denis Infanger
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View article: Device-based day-to-day and observer variability to quantify dilation capacity in the retinal microcirculation
Device-based day-to-day and observer variability to quantify dilation capacity in the retinal microcirculation Open
Introduction Dynamic retinal analysis (DVA) is a validated method to quantify microvascular endothelial function. This study aimed to analyze day-to-day variability, intra- and interobserver variability and differences between two device g…
View article: Sport-specific performance assessment with oxygen uptake measurements in time trials and critical power tests
Sport-specific performance assessment with oxygen uptake measurements in time trials and critical power tests Open
This study investigated the added value of peak oxygen uptake ( $${\dot{\text{V}}}$$ O 2peak ) measurements during a 4-min time trial (4TT) or a 3-min all-out test (3MT) as compared to a ramp cycling test to enhance sport-specific performa…
View article: Personalised, GIS-based counselling to promote habitual walking in mobility-limited and chronically ill older adults: protocol of the MOBITEC-Routes randomised controlled trial
Personalised, GIS-based counselling to promote habitual walking in mobility-limited and chronically ill older adults: protocol of the MOBITEC-Routes randomised controlled trial Open
View article: Deciphering the effect of exercise timing on glucose metabolism: a randomised controlled trial
Deciphering the effect of exercise timing on glucose metabolism: a randomised controlled trial Open
Background Effective glucose control is key to preventing cardiovascular disease and is positively influenced by exercise. The circadian system, an important regulator of glucose metabolism, suggests that the positive effects of exercise m…
View article: Left atrial stiffness is associated with age-related decrease in exercise capacity in healthy aging
Left atrial stiffness is associated with age-related decrease in exercise capacity in healthy aging Open
Background/Purpose Left atrial (LA) function contributes essentially to left ventricular filling. LA function and exercise capacity decline with age. This study aimed to determine whether age-related changes in LA function contribute to th…
View article: Reliability of hemodynamic parameters measured by bioimpedance cardiography at different intensities during incremental exercise testing
Reliability of hemodynamic parameters measured by bioimpedance cardiography at different intensities during incremental exercise testing Open
Background Bioimpedance cardiography offers a non-invasive and time-efficient method to measure hemodynamic parameters. Previous studies only investigated its reliability under steady-state conditions and at maximum load but not at ventila…
View article: Relative and absolute intensity accelerometer metrics decipher the effects of age, sex, and occupation on physical activity
Relative and absolute intensity accelerometer metrics decipher the effects of age, sex, and occupation on physical activity Open
View article: Deciphering the effect of exercise timing on glucose metabolism: a randomised controlled trial
Deciphering the effect of exercise timing on glucose metabolism: a randomised controlled trial Open
Introduction Impaired glycaemic control is a major risk factor for cardiovascular disease, the leading cause of death worldwide (Roth et al., 2020). Reducing sedentary behaviour and increasing physical activity are key strategies for impro…
View article: A single HIIT session does not alter blood sphingolipid levels in healthy young adults: The SphingoHIIT randomized controlled trial
A single HIIT session does not alter blood sphingolipid levels in healthy young adults: The SphingoHIIT randomized controlled trial Open
View article: Circulating amino acid signature features urea cycle alterations associated with coronary artery disease
Circulating amino acid signature features urea cycle alterations associated with coronary artery disease Open
View article: VascuFit: Aerobic exercise improves endothelial function independent of cardiovascular risk: A randomized-controlled trial
VascuFit: Aerobic exercise improves endothelial function independent of cardiovascular risk: A randomized-controlled trial Open
The improvement of macrovascular endothelial function by aerobic exercise training was independent from CV risk factors. Increased heterogeneity among endomiRs did not explain this effect, but suggests an adaptive response to the exercise …
View article: Intensity or volume: the role of physical activity in longevity
Intensity or volume: the role of physical activity in longevity Open
Aims To investigate how physical activity (PA) volume, intensity, duration, and fragmentation are associated with the risk of all-cause and cardiovascular disease mortality. To produce centile curves for PA volume and intensity representat…
View article: Subcutaneous advanced glycation end products, cardiovascular risk factors and vascular health during childhood development in a Swiss population
Subcutaneous advanced glycation end products, cardiovascular risk factors and vascular health during childhood development in a Swiss population Open
Background Skin-derived advanced glycation end products (sAGEs) have been associated with cardiovascular (CV) risk and mortality in adults. We hypothesize that cardiorespiratory fitness (CRF), body mass index (BMI) and vascular health are …
View article: Medium- to long-term health condition of patients post-COVID-19, exercise intolerance and potential mechanisms: A narrative review and perspective
Medium- to long-term health condition of patients post-COVID-19, exercise intolerance and potential mechanisms: A narrative review and perspective Open
Background: Patients recovering from COVID-19 often present with impaired health and persisting symptoms such as exercise intolerance ⩾3 months post-infection. Uncertainty remains about long-term recovery. We aimed to review studies examin…
View article: Effect of an eight-week high-intensity interval training programme on circulating sphingolipid levels in middle-aged adults at elevated cardiometabolic risk (SphingoFIT)—Protocol for a randomised controlled exercise trial
Effect of an eight-week high-intensity interval training programme on circulating sphingolipid levels in middle-aged adults at elevated cardiometabolic risk (SphingoFIT)—Protocol for a randomised controlled exercise trial Open
Introduction Evidence indicates that sphingolipid accumulation drives complex molecular alterations promoting cardiometabolic diseases. Clinically, it was shown that sphingolipids predict cardiometabolic risk independently of and beyond tr…
View article: Relative and absolute intensity accelerometer metrics decipher the effects of age, sex, and occupation on physical activity
Relative and absolute intensity accelerometer metrics decipher the effects of age, sex, and occupation on physical activity Open
Background To investigate whether quantifying both the absolute and relative intensity of physical activity (PA) improves understanding of age, sex, and occupation-related differences in PA in healthy adults aged 20–89. Methods In the cros…
View article: Increasing habitual walking in mobility-limited older adults through a personalized GIS-based intervention
Increasing habitual walking in mobility-limited older adults through a personalized GIS-based intervention Open
Background
Ample evidence supports the health benefits of low-intensity physical activity such as walking, which is universally accessible and impacted by neighbourhood environmental factors like green spaces and availability of local ame…
View article: Association of accelerometry-based and self-reported physical activity with cardiovascular risk in South African children
Association of accelerometry-based and self-reported physical activity with cardiovascular risk in South African children Open
The burden of non-communicable diseases is increasing, with risk factors emerging early in life. Physical activity reduces cardiovascular risk, but limited evidence exists for children from lower-income countries and mostly relies on self-…
View article: Accelerometer Metrics: Healthy Adult Reference Values, Associations with Cardiorespiratory Fitness, and Clinical Implications
Accelerometer Metrics: Healthy Adult Reference Values, Associations with Cardiorespiratory Fitness, and Clinical Implications Open
Purpose Accelerometer-assessed physical activity (PA) can be summarized using cut-point–free or population-specific cut-point–based outcomes. We aimed to 1) examine the interrelationship between cut-point–free (intensity gradient (IG) and …
View article: Cardiorespiratory fitness and development of childhood cardiovascular risk: The EXAMIN YOUTH follow-up study
Cardiorespiratory fitness and development of childhood cardiovascular risk: The EXAMIN YOUTH follow-up study Open
Background: Obesity- and hypertension-related cardiovascular (CV) risk has been shown to originate in childhood. Higher body mass index (BMI) and blood pressure (BP) have been associated with increased large artery stiffness and a lower mi…
View article: Investigating the circulating sphingolipidome response to a single high-intensity interval training session within healthy females and males in their twenties (SphingoHIIT): Protocol for a randomised controlled trial
Investigating the circulating sphingolipidome response to a single high-intensity interval training session within healthy females and males in their twenties (SphingoHIIT): Protocol for a randomised controlled trial Open
Introduction: Growing scientific evidence indicates that sphingolipids predict cardiometabolic risk, independently of and beyond traditional biomarkers such as low-density lipoprotein cholesterol. To date, it remains largely unknown if and…
View article: Bivariate relation of vascular health and blood pressure progression during childhood
Bivariate relation of vascular health and blood pressure progression during childhood Open
Retinal arteriolar diameter and PWV independently predict progression of childhood BP, while initial BP is linked to development of micro- and macrovascular impairments, describing a bivariate temporal relationship between vascular health …
View article: Prospective associations of physical fitness with spinal flexibility in childhood: implications for primary prevention of non-specific back pain
Prospective associations of physical fitness with spinal flexibility in childhood: implications for primary prevention of non-specific back pain Open
Objectives Early predictors for back pain need to be identified for the development of prevention strategies starting as early as childhood. For this purpose, the relationship between physical fitness and spinal flexibility at the age of s…
View article: Investigating the circulating sphingolipidome response to a single high-intensity interval training session within healthy females and males in their twenties (SphingoHIIT): Protocol for a randomised controlled trial
Investigating the circulating sphingolipidome response to a single high-intensity interval training session within healthy females and males in their twenties (SphingoHIIT): Protocol for a randomised controlled trial Open
Introduction: Growing scientific evidence indicates that sphingolipids predict cardiometabolic risk, independently of and beyond traditional biomarkers such as low-density lipoprotein cholesterol. To date, it remains largely unknown if and…
View article: Self-reported life-space mobility in the first year after ischemic stroke: longitudinal findings from the MOBITEC-Stroke project
Self-reported life-space mobility in the first year after ischemic stroke: longitudinal findings from the MOBITEC-Stroke project Open
View article: Reference values for cut-point-free and traditional accelerometer metrics and associations with cardiorespiratory fitness: a cross-sectional study of healthy adults aged 20 to 89 years
Reference values for cut-point-free and traditional accelerometer metrics and associations with cardiorespiratory fitness: a cross-sectional study of healthy adults aged 20 to 89 years Open
Objectives To compare the association between cardiorespiratory fitness (CRF) and cut-point-free accelerometer metrics (intensity gradient [IG] and average acceleration [AvAcc]) to that with traditional metrics in healthy adults aged 20 to…
View article: Reference values for accelerometer metrics and associations with cardiorespiratory fitness: a prospective cohort study of healthy adults and patients with heart failure
Reference values for accelerometer metrics and associations with cardiorespiratory fitness: a prospective cohort study of healthy adults and patients with heart failure Open
Background Accelerometry has gained increasing popularity and yields numerous physical activity (PA) outcomes (Rowlands et al., 2019). These include traditional cut-point-based (i.e. light, moderate, and vigorous PA) and cut-point-free met…
View article: Effect of lifestyle interventions on carotid arterial structure – The DR's EXTRA study
Effect of lifestyle interventions on carotid arterial structure – The DR's EXTRA study Open
No lifestyle-based interventions with medium-term duration on carotid atherosclerotic have been performed so far. We aimed to investigate whether guideline-based dietary and physical activity interventions slow the progression of atheroscl…
View article: Timed up-and-go performance is associated with objectively measured life space in patients 3 months after ischemic stroke: a cross-sectional observational study
Timed up-and-go performance is associated with objectively measured life space in patients 3 months after ischemic stroke: a cross-sectional observational study Open
View article: Investigating the circulating sphingolipidome response to a single high-intensity interval training session within healthy females and males in their twenties (SphingoHIIT): Protocol for a randomised controlled trial
Investigating the circulating sphingolipidome response to a single high-intensity interval training session within healthy females and males in their twenties (SphingoHIIT): Protocol for a randomised controlled trial Open
Introduction: Growing scientific evidence indicates that sphingolipids predict cardiometabolic risk, independently of and beyond traditional biomarkers such as low-density lipoprotein cholesterol. To date, it remains largely unknown if and…