Denis J. David
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View article: One-year versus three-year outcomes of DK-Crush versus Culotte for left main bifurcation lesions: A systematic review and meta-analysis of RCTs
One-year versus three-year outcomes of DK-Crush versus Culotte for left main bifurcation lesions: A systematic review and meta-analysis of RCTs Open
Background: The long-term comparative effectiveness of the Double Kissing (DK) Crush and Culotte stenting techniques for left main bifurcation lesions (LMBLs) remains a subject of clinical debate. This meta-analysis aimed to evaluate and c…
View article: Novel, small molecules targeting the 5-HT<sub>4</sub> receptor protect against stress-induced maladaptive behavior with efficacy across age
Novel, small molecules targeting the 5-HT<sub>4</sub> receptor protect against stress-induced maladaptive behavior with efficacy across age Open
BACKGROUND Stress is a risk factor for developing psychiatric disorders, including major depressive disorder (MDD). Compounds targeting the serotonin type 4 receptor (5-HT 4 R) hold promise as novel rapid-acting treatments of mood disorder…
View article: Altered Ventilation in Rats With Established Severe Monocrotaline‐Induced Pulmonary Hypertension: The Role of the Dorsal Hypothalamus
Altered Ventilation in Rats With Established Severe Monocrotaline‐Induced Pulmonary Hypertension: The Role of the Dorsal Hypothalamus Open
Pulmonary hypertension (PH) is a progressive condition characterized by muscularization of precapillary arteries, chronic inflammation, and a loss of the distal pulmonary circulation. These changes can be mimicked in rats by monocrotaline …
View article: Leveraging Fiber Photometry to Decipher Neural Circuits Underlying Anxiety in Mice
Leveraging Fiber Photometry to Decipher Neural Circuits Underlying Anxiety in Mice Open
Anxiety disorders rank among the most prevalent mental health conditions worldwide, significantly affecting patients' lives. They are frequently comorbid with other psychiatric disorders, often exacerbating their severity. Current pharmaco…
View article: Psilocybin as Transformative Fast‐Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms
Psilocybin as Transformative Fast‐Acting Antidepressant: Pharmacological Properties and Molecular Mechanisms Open
In the 1950s–60s, serotonergic psychedelic drugs were studied as potential adjuvants to psychotherapy to treat addiction and alcoholism. However, starting in the 70s, preclinical and clinical studies on psychedelics stopped for decades bec…
View article: The Gut Microbiota Is Altered in Antidepressant‐Free Depressed Patients and Is Associated With Depression Severity
The Gut Microbiota Is Altered in Antidepressant‐Free Depressed Patients and Is Associated With Depression Severity Open
Interest in the microbiota‐gut‐brain axis is increasing, but data on the associations between the microbiota and major depressive disorder (MDD), particularly in relation to symptomatology and treatment response, remain scarce and inconsis…
View article: Chronic α5‐<scp>GABA</scp>‐A Receptor Potentiation Promotes Mouse Adult Hippocampal Neurogenesis
Chronic α5‐<span>GABA</span>‐A Receptor Potentiation Promotes Mouse Adult Hippocampal Neurogenesis Open
Several lines of evidence implicate adult hippocampal neurogenesis (AHN) in cognitive functions, in mood‐ and anxiety‐related behaviors, and in the therapeutic effects of antidepressants. Augmenting α5‐γ‐Aminobutyric acid type A (GABAA) re…
View article: Neural correlates in basolateral and central amygdala during reward seeking in the face of punishment
Neural correlates in basolateral and central amygdala during reward seeking in the face of punishment Open
The inability to suppress actions despite adverse consequences is a hallmark of compulsive behaviors and is amygdala dependent. To study the amygdala’s role in responding despite adverse consequences, we compared single-unit activity in th…
View article: Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Male Mice
Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Male Mice Open
View article: Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions
Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions Open
View article: Habenular volume changes after venlafaxine treatment in patients with major depression
Habenular volume changes after venlafaxine treatment in patients with major depression Open
Background Habenula, a hub brain region controlling monoaminergic brain center, has been implicated in major depressive disorder (MDD) and as a possible target of antidepressant response. Nevertheless, the effect of antidepressant drug tre…
View article: Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions
Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions Open
( R,S )-ketamine (ketamine) has rapid and sustained antidepressant (AD) efficacy at sub-anesthetic doses in depressed patients. A metabolite of ketamine, including ( 2R,6R )-hydroxynorketamine (( 6 )-HNKs) has been reported to exert antide…
View article: Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Mice
Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Mice Open
BACKGROUND Impairments in behavioral pattern separation (BPS)—the ability to distinguish between similar contexts or experiences—contribute to memory interference and overgeneralization seen in many neuropsychiatric conditions, including d…
View article: Cover Image, Volume 33, Issue 10
Cover Image, Volume 33, Issue 10 Open
The cover image is based on the Research Article A complex relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin by Indira Mendez-David et al., https://doi.org/10.1002/hipo.2356…
View article: A tale of two receptors: simultaneous targeting of NMDARs and 5-HT<sub>4</sub>Rs exerts additive effects against stress
A tale of two receptors: simultaneous targeting of NMDARs and 5-HT<sub>4</sub>Rs exerts additive effects against stress Open
BACKGROUND Serotonin (5-HT) receptors and N -methyl-D-aspartate receptors (NMDARs) have both been implicated in the pathophysiology of depression and anxiety disorders. Here, we evaluated whether targeting both receptors through combined d…
View article: A complex relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin
A complex relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin Open
We investigated the mechanisms underlying the effects of the antidepressant fluoxetine on behavior and adult hippocampal neurogenesis (AHN). After confirming our earlier report that the signaling molecule β‐arrestin‐2 (β‐Arr2) is required …
View article: 128. Long Covid and Psychiatric Disorders 4 Months After a Hospitalization for COVID-19: A Cross Sectional Study
128. Long Covid and Psychiatric Disorders 4 Months After a Hospitalization for COVID-19: A Cross Sectional Study Open
View article: Peripheral proteomic changes after electroconvulsive seizures in a rodent model of non-response to chronic fluoxetine
Peripheral proteomic changes after electroconvulsive seizures in a rodent model of non-response to chronic fluoxetine Open
Major depressive disorder (MDD) is the psychiatric disorder with the highest prevalence in the world. Pharmacological antidepressant treatment (AD), such as selective serotonin reuptake inhibitors [SSRI, i.e., fluoxetine (Flx)] is the firs…
View article: The association of ARRB1 polymorphisms with response to antidepressant treatment in depressed patients
The association of ARRB1 polymorphisms with response to antidepressant treatment in depressed patients Open
Introduction: β-arrestin 1, a protein encoded by ARRB1 involved in receptor signaling, is a potential biomarker for the response to antidepressant drug (ATD) treatment in depression. We examined ARRB1 genetic variants for their association…
View article: P124. Which Patients Will Have Mental Disorders After Hospitalization for COVID-19?
P124. Which Patients Will Have Mental Disorders After Hospitalization for COVID-19? Open
View article: Blood microbiota and metabolomic signature of major depression before and after antidepressant treatment: a prospective case–control study
Blood microbiota and metabolomic signature of major depression before and after antidepressant treatment: a prospective case–control study Open
Background: The microbiota interacts with the brain through the gut–brain axis, and a distinct dysbiosis may lead to major depressive episodes. Bacteria can pass through the gut barrier and be found in the blood. Using a multiomic approach…
View article: Peripheral tryptophan and serotonin and kynurenine pathways in major depression: A case-control study
Peripheral tryptophan and serotonin and kynurenine pathways in major depression: A case-control study Open
Introduction The tryptophan pathway along with its two branches of metabolism to serotonin and kynurenine seems to be affected in major depression. In depressed patients, peripheral levels of tryptophan, serotonin, kynurenine and their met…
View article: Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin
Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin Open
Chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (CORT) correlates with reduced levels of both brain-derived neurotrophic factor (BDNF) and hippocampal neurogenesis. Precise…
View article: A non-linear relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin
A non-linear relation between levels of adult hippocampal neurogenesis and expression of the immature neuron marker doublecortin Open
We investigated the mechanisms underlying the effects of the antidepressant fluoxetine on behavior and adult hippocampal neurogenesis (AHN). After confirming our earlier report that the signaling molecule β2-arrestin is required for the an…
View article: Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine
Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine Open
View article: Cortical and raphe GABA<sub>A</sub>, AMPA receptors and glial GLT-1 glutamate transporter contribute to the sustained antidepressant activity of ketamine
Cortical and raphe GABA<sub>A</sub>, AMPA receptors and glial GLT-1 glutamate transporter contribute to the sustained antidepressant activity of ketamine Open
At sub-anaesthetic doses, ketamine, a non competitive N-methyl-d-aspartate (NMDA) receptor antagonist, has demonstrated remarkable and rapid antidepressant (AD) efficacy in patients with treatment-resistant depression (TRD). However, its m…
View article: A Non-Linear Relation between Levels of Adult Hippocampal Neurogenesis and Expression of the Immature Neuron Marker Doublecortin
A Non-Linear Relation between Levels of Adult Hippocampal Neurogenesis and Expression of the Immature Neuron Marker Doublecortin Open
View article: Peripheral tryptophan, serotonin, kynurenine, and their metabolites in major depression: A case–control study
Peripheral tryptophan, serotonin, kynurenine, and their metabolites in major depression: A case–control study Open
Aim Tryptophan is the sole precursor of both peripherally and centrally produced serotonin and kynurenine. In depressed patients, tryptophan, serotonin, kynurenine, and their metabolite levels remain unclear. Therefore, peripheral tryptoph…
View article: Prophylactic efficacy of 5-HT4R agonists against stress
Prophylactic efficacy of 5-HT4R agonists against stress Open
View article: S7B-09 SESSION 7B: HFM ROBIN - PART II SURGICAL CORRECTION OF SEVERE MANDIBULAR HYPOPLASIA IN HEMIFACIAL MICROSOMIA AT THE AUSTRALIAN CRANIOFACIAL UNIT.
S7B-09 SESSION 7B: HFM ROBIN - PART II SURGICAL CORRECTION OF SEVERE MANDIBULAR HYPOPLASIA IN HEMIFACIAL MICROSOMIA AT THE AUSTRALIAN CRANIOFACIAL UNIT. Open
Introduction: Repair of the severe mandibular deformity in hemifacial microsomia (HFM) remains a challenge and there is limited information in the literature regarding long term outcomes. The aim of this study was to evaluate long-term out…