Denis Plotnikov
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View article: Association Between Neck Pain and Osteoarthritis: A Bidirectional Mendelian Randomisation Study
Association Between Neck Pain and Osteoarthritis: A Bidirectional Mendelian Randomisation Study Open
Background Neck pain is one of the most prevalent musculoskeletal complaints and has recently been recognized as a frequent comorbidity of osteoarthritis (OA). Whether this association reflects shared biological mechanisms or bidirectional…
View article: Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking
Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking Open
View article: Genetic Variants Linked with the Concentration of Sex Hormone-Binding Globulin Correlate with Uterine Fibroid Risk
Genetic Variants Linked with the Concentration of Sex Hormone-Binding Globulin Correlate with Uterine Fibroid Risk Open
In this study we searched for correlations between polymorphic variants that determine sex hormone-binding globulin concentration (SHBGcon) and uterine fibroids (UFs). The work was performed on a sample of 1542 women (569 with UFs and 973 …
View article: Association between migraine and primary open-angle glaucoma: A two-sample Mendelian randomization study
Association between migraine and primary open-angle glaucoma: A two-sample Mendelian randomization study Open
Introduction To investigate the association of genetically predicted migraine with the risk of primary open-angle glaucoma (POAG). Methods To estimate the shared genetic basis of migraine and POAG, we conducted genome-wide genetic correlat…
View article: Effect of antihypertensive drugs on glaucoma: a Mendelian randomization and triangulation analysis
Effect of antihypertensive drugs on glaucoma: a Mendelian randomization and triangulation analysis Open
Importance Glaucoma is one of the world’s leading causes of irreversible blindness and effective interventions with less side effect and less cost were still in need. Objective To investigate the potential of repurposing antihypertensive d…
View article: GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma
GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma Open
The etiology of primary open angle glaucoma is constituted by both intraocular pressure-dependent and intraocular pressure-independent mechanisms. However, GWASs of traits affecting primary open angle glaucoma through mechanisms independen…
View article: Epidemiological Assessment of Factors Associated with Myopia in Medical Students
Epidemiological Assessment of Factors Associated with Myopia in Medical Students Open
Relevance. Myopia in students can lead to various problems with vision and affect quality of life and academic achievement. Aim. To analyze factors associated with the presence of myopia among medical students to develop effective methods …
View article: Factors Associated with the Myopia Degree in Students
Factors Associated with the Myopia Degree in Students Open
Purpose : to identify the most significant factors associated with myopic refraction in medical university students, which can be used for early prediction and prevention of myopia. Materials and methods . The survey data of students of 1–…
View article: Mendelian randomization in eye disorders (review)
Mendelian randomization in eye disorders (review) Open
Background: Mendelian randomization (MR) is an analytic approach in genetic epidemiology which uses the results of genome-wide association studies (GWAS) to assess causal relationships between various risk factors and phenotypes of interes…
View article: Genetic studies of normal tension glaucoma
Genetic studies of normal tension glaucoma Open
The paper presents a review of literature on genetic studies of normal tension glaucoma (NTG). Actually, it is known that NTG is a multifactorial disease whose development includes environmental and genetic factors. To date, a number of st…
View article: Time Spent Outdoors Partly Accounts for the Effect of Education on Myopia
Time Spent Outdoors Partly Accounts for the Effect of Education on Myopia Open
Accounting for the effects of time outdoors reduced the estimated causal effect of education on myopia by 40%. These results suggest about half of the relationship between education and myopia may be mediated by children not being outdoors…
View article: Editorial: Exploiting genetics and genomics to improve the understanding of eye diseases
Editorial: Exploiting genetics and genomics to improve the understanding of eye diseases Open
Editorial on the Research Topic
Exploiting genetics and genomics to improve the understanding of eye diseases
View article: Mendelian randomization: using genetic information in epidemiological studies (review)
Mendelian randomization: using genetic information in epidemiological studies (review) Open
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View article: Sex-Specific Features of the Correlation between GWAS-Noticeable Polymorphisms and Hypertension in Europeans of Russia
Sex-Specific Features of the Correlation between GWAS-Noticeable Polymorphisms and Hypertension in Europeans of Russia Open
The aim of the study was directed at studying the sex-specific features of the correlation between genome-wide association studies (GWAS)-noticeable polymorphisms and hypertension (HTN). In two groups of European subjects of Russia (n = 14…
View article: Directed acyclic graphs in planning clinical and epidemiological trials
Directed acyclic graphs in planning clinical and epidemiological trials Open
Establishing and quantifying the causal relationship between risk factors and outcomes are essential in epidemiology. Proper planning of epidemiological study makes it possible to avoid bias in estimating the effect and obtain significant …
View article: Analysis of the Prevalence of Myopia in Medical Students
Analysis of the Prevalence of Myopia in Medical Students Open
Myopia continues to be a serious public health problem due to the steady increase in the prevalence of the disease and the presence of serious complications leading to the loss of vision. The aim of the study was to investigate the prevale…
View article: Mendelian Randomization in Drug Repurposing
Mendelian Randomization in Drug Repurposing Open
The development of new drugs is a time consuming and costly process, so the use of approved drugs for new indications (repurposing) is a promising area of development for the pharmaceutical industry. There are two main approaches for drug …
View article: High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study
High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study Open
A range of different MR analysis methods provided evidence, in general, that the causal effect of BP on IOP (and POAG) was modest, or even zero. However, interpretation was complicated by SNPs associated with BP potentially having pleiotro…
View article: Hyperopia Is Not Causally Associated With a Major Deficit in Educational Attainment
Hyperopia Is Not Causally Associated With a Major Deficit in Educational Attainment Open
These findings suggest that moderate hyperopia does not cause a major deficit in educational attainment.
View article: Genetic Variants Associated With Human Eye Size Are Distinct From Those Conferring Susceptibility to Myopia
Genetic Variants Associated With Human Eye Size Are Distinct From Those Conferring Susceptibility to Myopia Open
These results support the hypothesis that genetic variants regulating eye size in emmetropic eyes do not overlap with those conferring susceptibility to myopia. This suggests that distinct biological pathways regulate normal eye growth and…
View article: Effect of Education on Myopia: Evidence from the United Kingdom ROSLA 1972 Reform
Effect of Education on Myopia: Evidence from the United Kingdom ROSLA 1972 Reform Open
Additional compulsory schooling due to the ROSLA 1972 reform was associated with a more negative refractive error, providing additional support for a causal relationship between education and myopia.
View article: Exploiting genetics to understand paediatric eye disorders
Exploiting genetics to understand paediatric eye disorders Open
The primary aim of this series of investigations was to identify causal risk factors for paediatric eye disorders (e.g. myopia, hyperopia, strabismus and amblyopia). A series of hypotheses was tested in this project by exploiting state-of-…
View article: Evidence That Emmetropization Buffers Against Both Genetic and Environmental Risk Factors for Myopia
Evidence That Emmetropization Buffers Against Both Genetic and Environmental Risk Factors for Myopia Open
Risk factors for myopia were associated with much larger effects in children in the extremes of the refractive error distribution, providing indirect evidence that emmetropization buffers against both genetic and environmental risk factors.
View article: Association Between Polygenic Risk Score and Risk of Myopia
Association Between Polygenic Risk Score and Risk of Myopia Open
A personalized medicine approach may be feasible for detecting very young children at risk of myopia. However, accuracy must improve further to merit uptake in clinical practice; currently, cycloplegic autorefraction remains a better indic…
View article: Genome-wide association study identifies a novel locus associated with strabismus
Genome-wide association study identifies a novel locus associated with strabismus Open
View article: Association between birth weight and refractive error in adulthood: a Mendelian randomisation study
Association between birth weight and refractive error in adulthood: a Mendelian randomisation study Open
Background Pathological myopia is one of the leading causes of blindness globally. Lower birth weight (BW) within the normal range has been reported to increase the risk of myopia, although findings conflict. We sought to estimate the caus…
View article: A commonly occurring genetic variant within the NPLOC4–TSPAN10–PDE6G gene cluster is associated with the risk of strabismus
A commonly occurring genetic variant within the NPLOC4–TSPAN10–PDE6G gene cluster is associated with the risk of strabismus Open
View article: Education and myopia: assessing the direction of causality by mendelian randomisation
Education and myopia: assessing the direction of causality by mendelian randomisation Open
This study shows that exposure to more years in education contributes to the rising prevalence of myopia. Increasing the length of time spent in education may inadvertently increase the prevalence of myopia and potential future visual disa…