Denise Balta
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View article: Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology
Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology Open
View article: SARS‐CoV‐2 Spike Protein Induces Time‐Dependent CTSL Upregulation in HeLa Cells and Alveolarspheres
SARS‐CoV‐2 Spike Protein Induces Time‐Dependent CTSL Upregulation in HeLa Cells and Alveolarspheres Open
Autophagy and lysosomal pathways are involved in the cell entry of SARS‐CoV‐2 virus. To infect the host cell, the spike protein of SARS‐CoV‐2 binds to the cell surface receptor angiotensin‐converting enzyme 2 (ACE2). To allow the fusion of…
View article: Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival
Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival Open
Lysosomes are the major cellular organelles responsible for nutrient recycling and degradation of cellular material. Maintenance of lysosomal integrity is essential for cellular homeostasis and lysosomal membrane permeabilization (LMP), in…
View article: Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models Open
Parkinson disease (PD) is a neurodegenerative disorder characterized by the abnormal intracellular accumulation of SNCA/α-synuclein. While the exact mechanisms underlying SNCA pathology are not fully understood, increasing evidence suggest…
View article: Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models Open
Parkinson disease (PD) is a neurodegenerative disorder characterized by the abnormal intracellular accumulation of SNCA/α-synuclein. While the exact mechanisms underlying SNCA pathology are not fully understood, increasing evidence suggest…
View article: Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models Open
Parkinson disease (PD) is a neurodegenerative disorder characterized by the abnormal intracellular accumulation of SNCA/α-synuclein. While the exact mechanisms underlying SNCA pathology are not fully understood, increasing evidence suggest…
View article: The role of lysosomes in alpha-synucleinopathies: a focus on glial cells
The role of lysosomes in alpha-synucleinopathies: a focus on glial cells Open
Lysosomes are the major degradative compartments within eukaryotic cells. Besides their role in the degradation and recycling of intra- and extracellular molecules, they further mediate important biological processes, such as immune signal…