Denise Feick
YOU?
Author Swipe
View article: Harnessing Open‐Source Solutions: Insights From the First Open Systems Pharmacology (<scp>OSP</scp>) Community Conference
Harnessing Open‐Source Solutions: Insights From the First Open Systems Pharmacology (<span>OSP</span>) Community Conference Open
In 2017, the free and open‐source software Open Systems Pharmacology (OSP) was launched. Since then, OSP has evolved from a small community into a diverse network of stakeholders committed to advancing open‐source solutions for model‐infor…
View article: A Comprehensive <scp>CYP2D6</scp> Drug–Drug–Gene Interaction Network for Application in Precision Dosing and Drug Development
A Comprehensive <span>CYP2D6</span> Drug–Drug–Gene Interaction Network for Application in Precision Dosing and Drug Development Open
Conducting clinical studies on drug–drug‐gene interactions (DDGIs) and extrapolating the findings into clinical dose recommendations is challenging due to the high complexity of these interactions. Here, physiologically‐based pharmacokinet…
View article: Physiologically‐based pharmacokinetic modeling of quinidine to establish a <scp>CYP3A4</scp>, P‐gp, and <scp>CYP2D6 drug–drug–gene</scp> interaction network
Physiologically‐based pharmacokinetic modeling of quinidine to establish a <span>CYP3A4</span>, P‐gp, and <span>CYP2D6 drug–drug–gene</span> interaction network Open
The antiarrhythmic agent quinidine is a potent inhibitor of cytochrome P450 (CYP) 2D6 and P‐glycoprotein (P‐gp) and is therefore recommended for use in clinical drug–drug interaction (DDI) studies. However, as quinidine is also a substrate…
View article: Physiologically based pharmacokinetic modeling of tacrolimus for <scp>food–drug</scp> and <scp>CYP3A drug–drug–gene</scp> interaction predictions
Physiologically based pharmacokinetic modeling of tacrolimus for <span>food–drug</span> and <span>CYP3A drug–drug–gene</span> interaction predictions Open
The immunosuppressant and narrow therapeutic index drug tacrolimus is metabolized mainly via cytochrome P450 (CYP) 3A4 and CYP3A5. For its pharmacokinetics (PK), high inter‐ and intra‐individual variability can be observed. Underlying caus…