Denise L. Doolan
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View article: When venom calms the storm: Stonefish venoms suppress LPS-induced Th1 cytokine expression and secretion in human PBMCs
When venom calms the storm: Stonefish venoms suppress LPS-induced Th1 cytokine expression and secretion in human PBMCs Open
Venoms are known to modulate immunological processes. In this study, we investigated the immunomodulatory properties of venoms from two stonefish species, Synanceia verrucosa (SvV) and Synanceia horrida (ShV), using immunological assays in…
View article: Distal airway epithelial progenitors mediate TGF-β release to drive lung CD8+ TRM induction following mucosal BCG vaccination
Distal airway epithelial progenitors mediate TGF-β release to drive lung CD8+ TRM induction following mucosal BCG vaccination Open
A principal reason for the high global morbidity and mortality of tuberculosis (TB) is the lack of efficacy of the only licensed TB vaccine, Bacillus Calmette-Guérin (BCG), as intradermal BCG does not induce local pulmonary immune memory. …
View article: Differential reactivity of <scp>SARS</scp>‐<scp>C</scp>o<scp>V</scp>‐2 S‐protein T‐cell epitopes in vaccinated versus naturally infected individuals
Differential reactivity of <span>SARS</span>‐<span>C</span>o<span>V</span>‐2 S‐protein T‐cell epitopes in vaccinated versus naturally infected individuals Open
Objectives Vaccine‐induced protective immunity against SARS‐CoV‐2 has proved difficult to sustain. Robust T‐cell responses are thought to play an important role, but T‐cell responses against the SARS‐CoV‐2 spike protein (S‐protein), the co…
View article: Sex Differences in Anti–Epstein-Barr Virus Antibody Responses
Sex Differences in Anti–Epstein-Barr Virus Antibody Responses Open
We investigated anti–Epstein-Barr virus (EBV) immunoglobulin A (IgA) and immunoglobulin G (IgG) responses by sex among 387 cancer-free individuals in Asia. Antibody responses were measured using an EBV proteome array to assess age-adjusted…
View article: Differential antibody response to EBV proteome following EBVST immunotherapy in EBV-associated lymphomas
Differential antibody response to EBV proteome following EBVST immunotherapy in EBV-associated lymphomas Open
Epstein-Barr virus (EBV) is associated with a diverse range of lymphomas. EBV-specific T-cell (EBVST) infusions have shown promise in safety and clinical effectiveness in treating EBV-associated lymphomas; however, not all patients respond…
View article: Lung epithelial progenitor-mediated release of TGF-β regulates induction and persistence of lung CD8<sup>+</sup>T<sub>RM</sub>cells following mucosal BCG vaccination
Lung epithelial progenitor-mediated release of TGF-β regulates induction and persistence of lung CD8<sup>+</sup>T<sub>RM</sub>cells following mucosal BCG vaccination Open
A principal reason for the high global morbidity and mortality of tuberculosis (TB) is the lack of efficacy of the only licensed TB vaccine, Bacillus Calmette-Guérin (BCG), as parenteral BCG does not induce local pulmonary immune memory. A…
View article: Aboriginal families living with MJD in remote Australia: questions of access and equity
Aboriginal families living with MJD in remote Australia: questions of access and equity Open
View article: Differential EBV protein-specific antibody response between responders and non-responders to EBVSTs immunotherapy
Differential EBV protein-specific antibody response between responders and non-responders to EBVSTs immunotherapy Open
Epstein–Barr virus (EBV) is associated with a diverse range of lymphomas. EBV-specific T-cell (EBVST) immunotherapies have shown promise in safety and clinical effectiveness in treating EBV-associated lymphomas, but not all patients respon…
View article: A proteome‐wide analysis unveils a core <scp>Epstein–Barr</scp> virus antibody signature of classic <scp>Hodgkin</scp> lymphoma across ethnically diverse populations
A proteome‐wide analysis unveils a core <span>Epstein–Barr</span> virus antibody signature of classic <span>Hodgkin</span> lymphoma across ethnically diverse populations Open
Epstein–Barr virus (EBV) is an oncogenic virus associated with various malignancies, including classical Hodgkin lymphoma (cHL). Despite its known association, the specific role of humoral immune response to EBV remains poorly characterize…
View article: Optimization and application of bacterial environmental DNA and RNA isolation for qualitative and quantitative studies
Optimization and application of bacterial environmental DNA and RNA isolation for qualitative and quantitative studies Open
Molecular detection of environmental DNA (eDNA) and RNA (eRNA) allows highly sensitive qualitative (i.e., presence or absence) and quantitative (i.e., abundance) monitoring of aquatic bacteria. However, bacterial molecular diagnostics are …
View article: Technical pitfalls when collecting, cryopreserving, thawing, and stimulating human T-cells
Technical pitfalls when collecting, cryopreserving, thawing, and stimulating human T-cells Open
The collection, cryopreservation, thawing, and culture of peripheral blood mononuclear cells (PBMCs) can profoundly influence T cell viability and immunogenicity. Gold-standard PBMC processing protocols have been developed by the Office of…
View article: Evaluating the stability of host-reference gene expression and simultaneously quantifying parasite burden and host immune responses in murine malaria
Evaluating the stability of host-reference gene expression and simultaneously quantifying parasite burden and host immune responses in murine malaria Open
View article: Small extracellular vesicles but not microvesicles from<i>Opisthorchis viverrini</i>promote cell proliferation in human cholangiocytes
Small extracellular vesicles but not microvesicles from<i>Opisthorchis viverrini</i>promote cell proliferation in human cholangiocytes Open
Chronic infection with O. viverrini has been linked to the development of cholangiocarcinoma (CCA), which is a major public health burden in the Lower Mekong River Basin countries, including Thailand, Lao PDR, Vietnam and Cambodia. Despite…
View article: Supplementary Table S3 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies
Supplementary Table S3 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies Open
Supplementary Table S3 shows positivity rates of the 46 individual markers among cases and controls in each study
View article: Supplementary Table S1 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies
Supplementary Table S1 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies Open
Supplementary Table S1 shows marker pathway allocation and corresponding citations
View article: Supplementary Table S2 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies
Supplementary Table S2 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies Open
Supplementary Table S2 shows summary of participant characteristics
View article: Data from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies
Data from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies Open
Background:Epstein–Barr virus (EBV) is linked to multiple cancers, including classical Hodgkin lymphoma (cHL), endemic Burkitt lymphoma (eBL), nasopharyngeal carcinoma (NPC), and extranodal natural killer/T-cell lymphoma (NKTCL).Methods:An…
View article: Supplementary Methods S1 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies
Supplementary Methods S1 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies Open
Supplementary Methods S1 expands upon data and statistical methods.
View article: Supplementary Table S2 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies
Supplementary Table S2 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies Open
Supplementary Table S2 shows summary of participant characteristics
View article: Supplementary Methods S1 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies
Supplementary Methods S1 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies Open
Supplementary Methods S1 expands upon data and statistical methods.
View article: Data from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies
Data from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies Open
Background:Epstein–Barr virus (EBV) is linked to multiple cancers, including classical Hodgkin lymphoma (cHL), endemic Burkitt lymphoma (eBL), nasopharyngeal carcinoma (NPC), and extranodal natural killer/T-cell lymphoma (NKTCL).Methods:An…
View article: Supplementary Table S1 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies
Supplementary Table S1 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies Open
Supplementary Table S1 shows marker pathway allocation and corresponding citations
View article: Supplementary Table S3 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies
Supplementary Table S3 from Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies Open
Supplementary Table S3 shows positivity rates of the 46 individual markers among cases and controls in each study
View article: Figure S3 from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan
Figure S3 from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan Open
Supplemental Figure 3
View article: Tables S2-S4 from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan
Tables S2-S4 from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan Open
Supplemental Tables S2-S4: Antibody Responses against 199 EBV peptide sequences and risk of early-stage NPC in a cross-sectional study
View article: Supplemental Methods from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan
Supplemental Methods from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan Open
Supplemental Methods
View article: Tables S2-S4 from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan
Tables S2-S4 from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan Open
Supplemental Tables S2-S4: Antibody Responses against 199 EBV peptide sequences and risk of early-stage NPC in a cross-sectional study
View article: Table S1 from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan
Table S1 from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan Open
Protein and sequence
View article: Data from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan
Data from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan Open
Background. Epstein–Barr virus (EBV) is necessary for the development of nasopharyngeal carcinoma (NPC). By adulthood, approximately 90% of individuals test EBV-positive, but only a fraction develop cancer. Factors that identify whi…
View article: Figure S1 from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan
Figure S1 from Identification of a Novel, EBV-Based Antibody Risk Stratification Signature for Early Detection of Nasopharyngeal Carcinoma in Taiwan Open
Percent sequence identity of 10 Chinese strains with protein sequences printed on the microarray