Denise R. Cooper
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View article: Multiomics Reveals Compartmentalized Immune Responses and Tissue-Vascular Signatures in Lyme Disease
Multiomics Reveals Compartmentalized Immune Responses and Tissue-Vascular Signatures in Lyme Disease Open
Lyme disease (LD) is growing in incidence, with nearly 500,000 cases diagnosed annually in the United States. Despite treatment, some patients experience persistent symptoms. The immune mechanisms underlying LD remain poorly understood. We…
View article: Regulation of bacterial phosphorelay systems
Regulation of bacterial phosphorelay systems Open
This review examines the regulatory mechanisms governing the catalytic activities of diverse classes of bacterial kinases and evaluates their viability as targets for the development of novel antimicrobial strategies.
View article: Ceramide synthesis regulates biogenesis and packaging of exosomal MALAT1 from adipose derived stem cells, increases dermal fibroblast migration and mitochondrial function
Ceramide synthesis regulates biogenesis and packaging of exosomal MALAT1 from adipose derived stem cells, increases dermal fibroblast migration and mitochondrial function Open
View article: Induction of beige‐like adipocyte markers and functions in 3T3‐L1 cells by Clk1 and PKCβII inhibitory molecules
Induction of beige‐like adipocyte markers and functions in 3T3‐L1 cells by Clk1 and PKCβII inhibitory molecules Open
Excessive dietary intake of fat results in its storage in white adipose tissue (WAT). Energy expenditure through lipid oxidation occurs in brown adipose tissue (BAT). Certain WAT depots can undergo a change termed beiging where markers tha…
View article: Ceramide synthesis regulates biogenesis and packaging of exosomal MALAT1 from adipose derived stem cells, increases dermal fibroblast migration and mitochondrial function.
Ceramide synthesis regulates biogenesis and packaging of exosomal MALAT1 from adipose derived stem cells, increases dermal fibroblast migration and mitochondrial function. Open
Background The function of exosomes, small extracellular vesicles (EVs) secreted from human adipose-derived stem cells (ADSC), is becoming increasingly recognized as a means of transferring the regenerative power of stem cells to injured c…
View article: Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus
Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus Open
Diet‐induced obesity, the metabolic syndrome, type 2 diabetes (DIO/MetS/T2DM), and their adverse sequelae have reached pandemic levels. In mice, DIO/MetS/T2DM initiation involves diet‐dependent increases in lipids that activate hepatic aty…
View article: Measurement of Organ-Specific and Acute-Phase Blood Protein Levels in Early Lyme Disease
Measurement of Organ-Specific and Acute-Phase Blood Protein Levels in Early Lyme Disease Open
Lyme disease results from infection of humans with the spirochete Borrelia burgdorferi. The first and most common clinical manifestation is the circular, inflamed skin lesion referred to as erythema migrans; later manifestations res…
View article: Measurement of organ-specific and acute-phase blood protein levels in early Lyme disease
Measurement of organ-specific and acute-phase blood protein levels in early Lyme disease Open
Lyme disease results from infection of humans with the spirochete Borrelia burgdorferi . The first and most common clinical manifestation is the circular, inflamed skin lesion referred to as erythema migrans; later manifestations result fr…
View article: Co-infections in Persons with Early Lyme Disease, New York, USA
Co-infections in Persons with Early Lyme Disease, New York, USA Open
In certain regions of New York state, USA, Ixodes scapularis ticks can potentially transmit 4 pathogens in addition to Borrelia burgdorferi: Anaplasma phagocytophilum, Babesia microti, Borrelia miyamotoi, and the deer tick virus subtype of…
View article: Long noncoding RNA MALAT1 in exosomes drives regenerative function and modulates inflammation-linked networks following traumatic brain injury
Long noncoding RNA MALAT1 in exosomes drives regenerative function and modulates inflammation-linked networks following traumatic brain injury Open
View article: Human Adipose-Derived Stem Cell Conditioned Media and Exosomes Containing<i>MALAT1</i>Promote Human Dermal Fibroblast Migration and Ischemic Wound Healing
Human Adipose-Derived Stem Cell Conditioned Media and Exosomes Containing<i>MALAT1</i>Promote Human Dermal Fibroblast Migration and Ischemic Wound Healing Open
Objective: Chronically ill patients heal recalcitrant ulcerative wounds more slowly. Human adipose-derived stem cells (hADSCs) play an important role in tissue regeneration and exosomes secreted by hADSC contribute to their paracrin…
View article: MALAT1 in human adipose stem cells modulates survival and alternative splicing of PKCδII in HT22 cells
MALAT1 in human adipose stem cells modulates survival and alternative splicing of PKCδII in HT22 cells Open
Brain injury may be caused by trauma or may occur in stroke and neurodegenerative diseases. Because the central nervous system is unable to regenerate efficiently, there is utmost interest in the use of stem cells to promote neuronal survi…
View article: Long-term Assessment of Post-Treatment Symptoms in Patients With Culture-Confirmed Early Lyme Disease
Long-term Assessment of Post-Treatment Symptoms in Patients With Culture-Confirmed Early Lyme Disease Open
PTLDS may persist for >10 years in some patients with culture-confirmed early Lyme disease. Such long-standing symptoms were not associated with functional impairment or a particular strain of B. burgdorferi.