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View article: Preclinical Evidence of the Effects of Sweet Flavors: Sweetness Increases Nicotine Intake and Seeking
Preclinical Evidence of the Effects of Sweet Flavors: Sweetness Increases Nicotine Intake and Seeking Open
Introduction The influence of early exposure to sweet and fruit flavors on subsequent nicotine use behaviors during adolescence remains poorly understood. To address this gap, we utilized a rodent model to simulate childhood flavor exposur…
View article: The influence of ovarian hormones on the putative mechanisms that promote female nicotine use
The influence of ovarian hormones on the putative mechanisms that promote female nicotine use Open
View article: Impact of vanilla flavor on nicotine taste, choice, intake, and seeking behaviors
Impact of vanilla flavor on nicotine taste, choice, intake, and seeking behaviors Open
View article: Phosphosulindac (OXT-328) prevents and reverses chemotherapy induced peripheral neuropathy in mice
Phosphosulindac (OXT-328) prevents and reverses chemotherapy induced peripheral neuropathy in mice Open
Background Chemotherapy-induced peripheral neuropathy (CIPN), a side effect of chemotherapy, is particularly difficult to treat. We explored whether phosphosulindac (PS), a modified NSAID, could treat CIPN. Methods CIPN was induced in male…
View article: Chronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine’s effects in adolescent rats
Chronic oral nicotine exposure decreases aversive taste of nicotine, increases nicotine withdrawal and reinstatement, but cherry flavor does not alter nicotine’s effects in adolescent rats Open
View article: Pharmacological characterization of 5-iodo-A-85380, a β2-selective nicotinic receptor agonist, in mice
Pharmacological characterization of 5-iodo-A-85380, a β2-selective nicotinic receptor agonist, in mice Open
Background: Because of their implications in several pathological conditions, α4β2* nicotinic acetylcholine receptors (nAChRs) are potential targets for the treatment of nicotine dependence, pain, and many psychiatric and neurodegenerative…
View article: Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein
Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein Open
View article: Genotypic Differences in the Effects of Menthol on Nicotine Intake and Preference in Mice
Genotypic Differences in the Effects of Menthol on Nicotine Intake and Preference in Mice Open
Menthol has been shown to exacerbate elements of nicotine addiction in humans and rodents; however, the mechanisms mediating its effects are not fully understood. This study examined the impact of genetic factors in menthol’s effects on or…
View article: Animal Models to Investigate the Impact of Flavors on Nicotine Addiction and Dependence
Animal Models to Investigate the Impact of Flavors on Nicotine Addiction and Dependence Open
Background: Tobacco use in humans is a long-standing public health concern. Flavors are common additives in tobacco and alternative tobacco products, added to mask nicotine’s harsh orosensory effects and increase the appeal of these produc…
View article: Cholinergic and dopaminergic‐mediated motivated behavior in healthy states and in substance use and mood disorders
Cholinergic and dopaminergic‐mediated motivated behavior in healthy states and in substance use and mood disorders Open
Acetylcholine is an important neuromodulator of the mesolimbic dopamine (DA) system, which itself is a mediator of motivated behavior. Motivated behavior can be described by two primary components, termed directional and activational motiv…
View article: Evaluation of Flavor Effects on Oral Nicotine Liking and/or Disliking Using the Taste Reactivity Test in Rats
Evaluation of Flavor Effects on Oral Nicotine Liking and/or Disliking Using the Taste Reactivity Test in Rats Open
Introduction Tobacco product flavors may change the sensory properties of nicotine, such as taste and olfactory cues, which may alter nicotine reward and aversion and nicotine taking behavior. The hedonic or aversive value of a taste stimu…
View article: Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype
Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype Open
View article: Impact of menthol on nicotine intake and preference in mice: Concentration, sex, and age differences
Impact of menthol on nicotine intake and preference in mice: Concentration, sex, and age differences Open
View article: Conditional expression of HIV‐1 tat in the mouse alters the onset and progression of tonic, inflammatory and neuropathic hypersensitivity in a sex‐dependent manner
Conditional expression of HIV‐1 tat in the mouse alters the onset and progression of tonic, inflammatory and neuropathic hypersensitivity in a sex‐dependent manner Open
Background At least one‐third of HIV‐1‐afflicted individuals experience peripheral neuropathy. Although the underlying mechanisms are not known, they may involve neurotoxic HIV‐1 proteins. Methods We assessed the influence of the neurotoxi…
View article: Investigating The Role of AEG-1 in Mouse Models of Pain
Investigating The Role of AEG-1 in Mouse Models of Pain Open
Background: Astrocyte Elevated Gene 1 (AEG-1) is a multifunctional protein shown to be a regulator of transcription and multiple intracellular signaling pathways. The role of AEG-1 in cellular inflammation appears to be primarily facilitat…
View article: A silent agonist of α7 nicotinic acetylcholine receptors modulates inflammation ex vivo and attenuates EAE
A silent agonist of α7 nicotinic acetylcholine receptors modulates inflammation ex vivo and attenuates EAE Open
View article: Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation
Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation Open
Background: Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studi…
View article: Pharmacological mechanisms of alcohol analgesic-like properties in mouse models of acute and chronic pain
Pharmacological mechanisms of alcohol analgesic-like properties in mouse models of acute and chronic pain Open
View article: Adolescent but not adult ethanol binge drinking modulates ethanol behavioral effects in mice later in life
Adolescent but not adult ethanol binge drinking modulates ethanol behavioral effects in mice later in life Open
View article: The α7 nicotinic receptor silent agonist R-47 prevents and reverses paclitaxel-induced peripheral neuropathy in mice without tolerance or altering nicotine reward and withdrawal
The α7 nicotinic receptor silent agonist R-47 prevents and reverses paclitaxel-induced peripheral neuropathy in mice without tolerance or altering nicotine reward and withdrawal Open
View article: Assessing nicotine dependence using an oral nicotine free-choice paradigm in mice
Assessing nicotine dependence using an oral nicotine free-choice paradigm in mice Open
View article: Neuropathic insult increases the responsiveness to acetic acid in mice
Neuropathic insult increases the responsiveness to acetic acid in mice Open
Chronic neuropathic pain is a burden to millions of patients every day. Patients with neuropathic pain will also experience acute pain throughout their everyday lives adding to their nociceptive burden. Using nociceptive models in mice thi…
View article: C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception
C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception Open
Sensitivity to different pain modalities has a genetic basis that remains largely unknown. Employing closely related inbred mouse substrains can facilitate gene mapping of nociceptive behaviors in preclinical pain models. We previously rep…
View article: C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception
C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception Open
Sensitivity to different pain modalities has a genetic basis that remains largely unknown. Employing closely related inbred mouse substrains can facilitate gene mapping of nociceptive behaviors in preclinical pain models. We previously rep…
View article: Early adolescent nicotine exposure affects later-life hippocampal mu-opioid receptors activity and morphine reward but not physical dependence in male mice
Early adolescent nicotine exposure affects later-life hippocampal mu-opioid receptors activity and morphine reward but not physical dependence in male mice Open
View article: The Antinociceptive and Anti-Inflammatory Properties of the α7 nAChR Weak Partial Agonist p-CF3 N,N-diethyl-N′-phenylpiperazine
The Antinociceptive and Anti-Inflammatory Properties of the α7 nAChR Weak Partial Agonist p-CF3 N,N-diethyl-N′-phenylpiperazine Open
View article: Knockout of alpha 5 nicotinic acetylcholine receptors subunit alters ethanol-mediated behavioral effects and reward in mice
Knockout of alpha 5 nicotinic acetylcholine receptors subunit alters ethanol-mediated behavioral effects and reward in mice Open
View article: New insights on the effects of varenicline on nicotine reward, withdrawal and hyperalgesia in mice
New insights on the effects of varenicline on nicotine reward, withdrawal and hyperalgesia in mice Open
View article: Reduced intraepidermal nerve fibre density, glial activation, and sensory changes in HIV type-1 Tat-expressing female mice: involvement of Tat during early stages of HIV-associated painful sensory neuropathy
Reduced intraepidermal nerve fibre density, glial activation, and sensory changes in HIV type-1 Tat-expressing female mice: involvement of Tat during early stages of HIV-associated painful sensory neuropathy Open
Introduction: HIV infection is associated with chronic pain states, including sensory neuropathy, which affects greater than 40% of patients. Objectives and Methods: To determine the impact of HIV-Tat induction on nociceptive behaviour in …
View article: New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on α7 nAChRs
New Insights on Neuronal Nicotinic Acetylcholine Receptors as Targets for Pain and Inflammation: A Focus on α7 nAChRs Open
This review provides the reader recent insights on α7 nAChRs from structure and function to the latest findings on the pharmacology and therapeutic targeting of these receptors for the treatment of pain and inflammation.