Deniz Ragipoglu
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View article: TAM receptors control actomyosin dynamics in osteoclasts via RHOA-COFILIN-MYOSIN II signaling
TAM receptors control actomyosin dynamics in osteoclasts via RHOA-COFILIN-MYOSIN II signaling Open
The TAM family of receptor tyrosine kinases were recently identified to regulate bone homeostasis by controlling osteoblasts and bone formation. Despite extensive knowledge of TAM receptor function in the mononuclear phagocyte system, the …
View article: The Role of TAM Receptors in Bone
The Role of TAM Receptors in Bone Open
The TAM (TYRO3, MERTK, and AXL) family of receptor tyrosine kinases are pleiotropic regulators of adult tissue homeostasis maintaining organ integrity and self-renewal. Disruption of their homeostatic balance fosters pathological condition…
View article: Role of Mast-Cell-Derived RANKL in Ovariectomy-Induced Bone Loss in Mice
Role of Mast-Cell-Derived RANKL in Ovariectomy-Induced Bone Loss in Mice Open
Mast cells may contribute to osteoporosis development, because patients with age-related or post-menopausal osteoporosis exhibit more mast cells in the bone marrow, and mastocytosis patients frequently suffer from osteopenia. We previously…
View article: Mast Cells Drive Systemic Inflammation and Compromised Bone Repair After Trauma
Mast Cells Drive Systemic Inflammation and Compromised Bone Repair After Trauma Open
There is evidence that mast cells contribute to inflammation induced by hemorrhagic shock, severe tissue injury or sepsis. Mast cells are highly responsive to alarm signals generated after trauma, and release many inflammatory mediators in…
View article: Mast Cells Trigger Disturbed Bone Healing in Osteoporotic Mice
Mast Cells Trigger Disturbed Bone Healing in Osteoporotic Mice Open
Mast cells are important tissue-resident sensor and effector immune cells but also play a major role in osteoporosis development. Mast cells are increased in numbers in the bone marrow of postmenopausal osteoporotic patients, and mast cell…
View article: Wnt1 Boosts Fracture Healing by Enhancing Bone Formation in the Fracture Callus
Wnt1 Boosts Fracture Healing by Enhancing Bone Formation in the Fracture Callus Open
Despite considerable improvement in fracture care, 5%–10% of all fractures still heal poorly or result in nonunion formation. Therefore, there is an urgent need to identify new molecules that can be used to improve bone fracture healing. O…
View article: The Role of Mast Cells in Bone Metabolism and Bone Disorders
The Role of Mast Cells in Bone Metabolism and Bone Disorders Open
Mast cells (MCs) are important sensor and effector cells of the immune system that are involved in many physiological and pathological conditions. Increasing evidence suggests that they also play an important role in bone metabolism and bo…