Deniz Ugurlar
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View article: Architectures of photosynthetic RC-LH1 supercomplexes from <i>Rhodobacter blasticus</i>
Architectures of photosynthetic RC-LH1 supercomplexes from <i>Rhodobacter blasticus</i> Open
The reaction center–light-harvesting complex 1 (RC-LH1) plays an essential role in the primary reactions of bacterial photosynthesis. Here, we present high-resolution structures of native monomeric and dimeric RC-LH1 supercomplexes from Rh…
View article: In-depth structure-function profiling of the complex formation between clotting factor VIII and heme
In-depth structure-function profiling of the complex formation between clotting factor VIII and heme Open
Our study provides not only novel molecular insights into the FVIII-heme interaction and its physiological relevance, but also strongly suggests the reduction of the intrinsic pathway and the accentuation of the final clotting step (by, fo…
View article: C1q binding to surface-bound IgG is stabilized by C1r <sub>2</sub> s <sub>2</sub> proteases
C1q binding to surface-bound IgG is stabilized by C1r <sub>2</sub> s <sub>2</sub> proteases Open
Significance Antibody-dependent complement activation plays a major role in various pathophysiological processes in our body, including infection, inflammation, autoimmunity, and transplant rejection. In order to activate complement, antib…
View article: C1q binding to surface-bound IgG is stabilized by C1r<sub>2</sub>s<sub>2</sub>proteases
C1q binding to surface-bound IgG is stabilized by C1r<sub>2</sub>s<sub>2</sub>proteases Open
Complement is an important effector mechanism for antibody-mediated clearance of infections and tumor cells. Upon binding to target cells, the antibody’s constant (Fc) domain recruits complement component C1 to initiate a proteolytic casca…
View article: Structural diversity in the atomic resolution 3D fingerprint of the titin M-band segment
Structural diversity in the atomic resolution 3D fingerprint of the titin M-band segment Open
In striated muscles, molecular filaments are largely composed of long protein chains with extensive arrays of identically folded domains, referred to as "beads-on-a-string". It remains a largely unresolved question how these domains have d…
View article: Understanding the first steps of the complement classical pathway: Structural studies on C1-antibody complexes
Understanding the first steps of the complement classical pathway: Structural studies on C1-antibody complexes Open
The complement system is a complex network of plasma and membrane-associated proteins, which can produce effective immune responses to infectious micro-organisms. Deficiencies of complement proteins cause diseases like systemic lupus eryth…
View article: Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen
Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen Open