Dennis Böttner
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View article: Single-cell landscape of peripheral immune cells in MASLD/MASH
Single-cell landscape of peripheral immune cells in MASLD/MASH Open
Background: Metabolic dysfunction–associated steatotic liver disease (MASLD) progresses to metabolic dysfunction–associated steatohepatitis (MASH) and is a major cause of liver cirrhosis. Although liver inflammation is the hallmark feature…
View article: Deciphering integration loci of CHO manufacturing cell lines using long read nanopore sequencing
Deciphering integration loci of CHO manufacturing cell lines using long read nanopore sequencing Open
Despite advances in genetic characterization of Chinese hamster ovary (CHO) cell lines regarding identification of integration sites using next generation sequencing, e.g. targeted locus amplification sequencing (TLA-seq), the concatemer s…