Dennis E. Kyle
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View article: Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malaria 2178
Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malaria 2178 Open
Description Plasmodium parasites develop and replicate within the hepatocytes before infecting the erythrocytes and initiating clinical malaria. Although type-I interferons (IFNs) can hinder Plasmodium infection within the liver, the under…
View article: Characterization of β-Carboline Derivatives Reveals a High Barrier to Resistance and Potent Activity against Ring-Stage and DHA-Induced Dormant <i>Plasmodium falciparum</i>
Characterization of β-Carboline Derivatives Reveals a High Barrier to Resistance and Potent Activity against Ring-Stage and DHA-Induced Dormant <i>Plasmodium falciparum</i> Open
Malaria, caused by Plasmodium falciparum, remains a major global health challenge, with an estimated 263 million new infections and 597,000 deaths annually. Increasing resistance to current antimalarial drugs underscores the urgent need fo…
View article: A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites
A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites Open
Radical cure of Plasmodium vivax malaria must include elimination of quiescent ‘hypnozoite’ forms in the liver; however, the only FDA-approved treatments are contraindicated in many vulnerable populations. To identify new drugs and drug ta…
View article: Secreted small RNAs of Naegleria fowleri are biomarkers for diagnosis of primary amoebic meningoencephalitis
Secreted small RNAs of Naegleria fowleri are biomarkers for diagnosis of primary amoebic meningoencephalitis Open
Rapid and accurate diagnostics are needed to effectively detect and treat primary amoebic meningoencephalitis (PAM) caused by the free-living amoeba, Naegleria fowleri. Delayed diagnosis and similarities to other causes of meningitis contr…
View article: Virulence of <i>Naegleria fowleri</i> isolates varies significantly in the mouse model of primary amoebic meningoencephalitis
Virulence of <i>Naegleria fowleri</i> isolates varies significantly in the mouse model of primary amoebic meningoencephalitis Open
Naegleria fowleri is a small free-living amoeba that causes an acute, fatal disease called primary amoebic meningoencephalitis (PAM). One persisting question is why few people succumb to disease when so many are potentially exposed. We tes…
View article: Secreted small RNAs of Naegleria fowleri are biomarkers for diagnosis of primary amoebic meningoencephalitis
Secreted small RNAs of Naegleria fowleri are biomarkers for diagnosis of primary amoebic meningoencephalitis Open
Rapid and accurate diagnostics are needed to effectively detect and treat primary amoebic meningoencephalitis (PAM) caused by the free-living amoeba, Naegleria fowleri. Delayed diagnosis and similarities to other causes of meningitis contr…
View article: Secreted small RNAs of Naegleria fowleri are biomarkers for diagnosis of primary amoebic meningoencephalitis
Secreted small RNAs of Naegleria fowleri are biomarkers for diagnosis of primary amoebic meningoencephalitis Open
Rapid and accurate diagnostics are needed to effectively detect and treat primary amoebic meningoencephalitis (PAM) caused by Naegleria fowleri (Nf). Delayed diagnosis and similarities to other causes of meningitis contribute to a case mor…
View article: Discovery and optimization of a novel carboxamide scaffold with selective antimalarial activity
Discovery and optimization of a novel carboxamide scaffold with selective antimalarial activity Open
Artemisinin combination therapies (ACTs) are critical components of malaria control worldwide. Alarmingly, ACTs have begun to fail, owing to the rise in artemisinin resistance. Thus, there is an urgent need for an expanded set of novel ant…
View article: Secreted small RNAs of <i>Naegleria fowleri</i> are biomarkers for diagnosis of primary amoebic meningoencephalitis
Secreted small RNAs of <i>Naegleria fowleri</i> are biomarkers for diagnosis of primary amoebic meningoencephalitis Open
Rapid and accurate diagnostics are needed to effectively detect and treat primary amoebic meningoencephalitis (PAM) caused by Naegleria fowleri ( Nf ). Delayed diagnosis and similarities to other causes of meningitis contribute to a case m…
View article: Discovery and Optimization of a Novel Carboxamide Scaffold with Selective Antimalarial Activity
Discovery and Optimization of a Novel Carboxamide Scaffold with Selective Antimalarial Activity Open
Artemisinin combination therapies (ACTs) are critical components of malaria control worldwide. Alarmingly, ACTs have begun to fail, owing to the rise in artemisinin resistance. Thus, there is an urgent need for an expanded set of novel ant…
View article: Screening the Global Health Priority Box against Plasmodium berghei liver stage parasites using an inexpensive luciferase detection protocol
Screening the Global Health Priority Box against Plasmodium berghei liver stage parasites using an inexpensive luciferase detection protocol Open
Background Malaria, a disease caused by parasites of the genus Plasmodium , continues to impact many regions globally. The rise in resistance to artemisinin-based anti-malarial drugs highlights the need for new treatments. Ideally, new ant…
View article: Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malaria
Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malaria Open
Plasmodium parasites undergo development and replication within the hepatocytes before infecting the erythrocytes and initiating clinical malaria. Although type-I interferons (IFNs) are known to hinder Plasmodium infection within the liver…
View article: Screening the Global Health Priority Box Against Plasmodium berghei Liver Stage Parasites Using an Inexpensive Luciferase Detection Protocol
Screening the Global Health Priority Box Against Plasmodium berghei Liver Stage Parasites Using an Inexpensive Luciferase Detection Protocol Open
Background Malaria, a disease caused by parasites of the genus Plasmodium, continues to impact many regions globally. The rise in resistance to artemisinin-based antimalarial drugs highlights the need for new treatments. Ideally, new antim…
View article: A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites
A drug repurposing approach reveals targetable epigenetic pathways in Plasmodium vivax hypnozoites Open
Radical cure of Plasmodium vivax malaria must include elimination of quiescent ‘hypnozoite’ forms in the liver; however, the only FDA-approved treatments are contraindicated in many vulnerable populations. To identify new drugs and drug ta…
View article: A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites
A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites Open
Radical cure of Plasmodium vivax malaria must include elimination of quiescent ‘hypnozoite’ forms in the liver; however, the only FDA-approved treatments are contraindicated in many vulnerable populations. To identify new drugs and drug ta…
View article: Extended blood stage sensitivity profiles of <i>Plasmodium cynomolgi</i> to doxycycline and tafenoquine, as a model for <i>Plasmodium vivax</i>
Extended blood stage sensitivity profiles of <i>Plasmodium cynomolgi</i> to doxycycline and tafenoquine, as a model for <i>Plasmodium vivax</i> Open
Testing Plasmodium vivax antimicrobial sensitivity is limited to ex vivo schizont maturation assays, which preclude determining the IC50s of delayed action antimalarials such as doxycycline. Using Plasmodium cynomolgi as a model for P. viv…
View article: Extended blood stage sensitivity profiles of<i>Plasmodium vivax</i>to doxycycline and tafenoquine using<i>Plasmodium cynomolgi</i>as a model
Extended blood stage sensitivity profiles of<i>Plasmodium vivax</i>to doxycycline and tafenoquine using<i>Plasmodium cynomolgi</i>as a model Open
Testing Plasmodium vivax antimicrobial sensitivity is limited to ex vivo schizont maturation assays, which precludes determining the IC 50s of delayed action antimalarials such as doxycycline. Using Plasmodium cynomolgi as a model for P. v…
View article: Oviposition status and sugar availability influence measures of transmission potential in malaria-infected mosquitoes
Oviposition status and sugar availability influence measures of transmission potential in malaria-infected mosquitoes Open
Background Like other oviparous organisms, the gonotrophic cycle of mosquitoes is not complete until they have selected a suitable habitat to oviposit. In addition to the evolutionary constraints associated with selective oviposition behav…
View article: In Vitro Antimalarial Activity of Trichothecenes against Liver and Blood Stages of <i>Plasmodium</i> Species
In Vitro Antimalarial Activity of Trichothecenes against Liver and Blood Stages of <i>Plasmodium</i> Species Open
Trichothecenes (TCNs) are a large group of tricyclic sesquiterpenoid mycotoxins that have intriguing structural features and remarkable biological activities. Herein, we focused on three TCNs (anguidine, verrucarin A, and verrucarol) and t…
View article: Corrigendum: Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes
Corrigendum: Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes Open
[This corrects the article DOI: 10.3389/fmicb.2023.1149145.].
View article: Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases
Shotgun Kinetic Target-Guided Synthesis Approach Enables the Discovery of Small-Molecule Inhibitors against Pathogenic Free-Living Amoeba Glucokinases Open
Pathogenic free-living amoebae (pFLA) can cause life-threatening central nervous system (CNS) infections and warrant the investigation of new chemical agents to combat the rise of infection from these pathogens. Naegleria fowleri glucokina…
View article: Characterization of the extracellular vesicles, ultrastructural morphology, and intercellular interactions of multiple clinical isolates of the brain-eating amoeba, Naegleria fowleri
Characterization of the extracellular vesicles, ultrastructural morphology, and intercellular interactions of multiple clinical isolates of the brain-eating amoeba, Naegleria fowleri Open
Introduction As global temperatures rise to unprecedented historic levels, so too do the latitudes of habitable niches for the pathogenic free-living amoeba, Naegleria fowleri . This opportunistic parasite causes a rare, but >97% fatal,…
View article: Sheptide A: an antimalarial cyclic pentapeptide from a fungal strain in the Herpotrichiellaceae
Sheptide A: an antimalarial cyclic pentapeptide from a fungal strain in the Herpotrichiellaceae Open
As part of ongoing efforts to isolate biologically active fungal metabolites, a cyclic pentapeptide, sheptide A ( 1 ), was discovered from strain MSX53339 ( Herpotrichiellaceae ). The structure and sequence of 1 were determined primarily b…
View article: Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes
Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes Open
Acanthamoeba species, Naegleria fowleri , and Balamuthia mandrillaris are opportunistic pathogens that cause a range of brain, skin, eye, and disseminated diseases in humans and animals. These pathogenic free-living amoebae (pFLA) are comm…