Dennis E. Mayock
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View article: Prenatal Magnesium Sulfate Exposure Is Not Associated with Different Neurodevelopmental Outcomes by Sex in Extremely Preterm Infants
Prenatal Magnesium Sulfate Exposure Is Not Associated with Different Neurodevelopmental Outcomes by Sex in Extremely Preterm Infants Open
Background/Objectives: Magnesium sulfate (MgSO4) has historically been used in obstetrics as a tocolytic and to prevent eclamptic seizures. MgSO4 has also been investigated as a potential neonatal neuroprotectant for infants born preterm. …
View article: Childhood Differences in Healthcare Utilization Between Extremely Preterm Infants and the General Population
Childhood Differences in Healthcare Utilization Between Extremely Preterm Infants and the General Population Open
Background/Objective(s): Post-discharge clinical needs of extremely preterm (EP) infants are not well defined. The aim of this study is to evaluate healthcare utilization after discharge in infants born EP and compare it to the general ped…
View article: Perinatal arterial ischemic stroke diagnosed in infants receiving therapeutic hypothermia for hypoxic-ischemic encephalopathy
Perinatal arterial ischemic stroke diagnosed in infants receiving therapeutic hypothermia for hypoxic-ischemic encephalopathy Open
Background Both perinatal arterial ischemic stroke (PAIS) and hypoxic-ischemic encephalopathy (HIE) can present with neonatal encephalopathy. We hypothesized that among infants undergoing therapeutic hypothermia, presence of PAIS is associ…
View article: Table of Contents
Table of Contents Open
View article: Genetic and Congenital Anomalies in Infants With Hypoxic-Ischemic Encephalopathy
Genetic and Congenital Anomalies in Infants With Hypoxic-Ischemic Encephalopathy Open
View article: Relationship of Neonatal Seizure Burden Before Treatment and Response to Initial Antiseizure Medication
Relationship of Neonatal Seizure Burden Before Treatment and Response to Initial Antiseizure Medication Open
Maximal seizure burden may be more important than other, more commonly used measures in predicting response to acute seizure treatments.
View article: Yoga in the Neonatal Intensive Care Unit for parents: a needs assessment and acceptability study
Yoga in the Neonatal Intensive Care Unit for parents: a needs assessment and acceptability study Open
Aim: To explore NICU parent and staff attitudes towards yoga for parents as a stress reduction intervention and determine the acceptability of an online yoga curriculum. Methods: A 13-item survey on yoga for parents was emailed to clinical…
View article: Contemporary definitions of infant growth failure and neurodevelopmental and behavioral outcomes in extremely premature infants at two years of age
Contemporary definitions of infant growth failure and neurodevelopmental and behavioral outcomes in extremely premature infants at two years of age Open
Background Associations of 2-year neurodevelopmental and behavioral outcomes with growth trajectories of preterm infants are unknown. Methods This secondary analysis of a preterm cohort examined in-hospital and discharge to 2-year changes …
View article: Evolution of the Sarnat exam and association with 2-year outcomes in infants with moderate or severe hypoxic-ischaemic encephalopathy: a secondary analysis of the HEAL Trial
Evolution of the Sarnat exam and association with 2-year outcomes in infants with moderate or severe hypoxic-ischaemic encephalopathy: a secondary analysis of the HEAL Trial Open
Objective To study the association between the Sarnat exam (SE) performed before and after therapeutic hypothermia (TH) and outcomes at 2 years in infants with moderate or severe hypoxic-ischaemic encephalopathy (HIE). Design Secondary ana…
View article: Time to Reaching Target Cooling Temperature and 2-year Outcomes in Infants with Hypoxic-Ischemic Encephalopathy
Time to Reaching Target Cooling Temperature and 2-year Outcomes in Infants with Hypoxic-Ischemic Encephalopathy Open
View article: Association of EEG Background and Neurodevelopmental Outcome in Neonates With Hypoxic-Ischemic Encephalopathy Receiving Hypothermia
Association of EEG Background and Neurodevelopmental Outcome in Neonates With Hypoxic-Ischemic Encephalopathy Receiving Hypothermia Open
EEG background is strongly associated with NDI at age 2 years. These results can be used to assist health care providers to plan follow-up care and counsel families for decision-making related to goals of care.
View article: Time to Regain Birthweight and Association with Neurodevelopmental Outcomes among Extremely Preterm Newborns
Time to Regain Birthweight and Association with Neurodevelopmental Outcomes among Extremely Preterm Newborns Open
Objective Determine association between time to regain birthweight and 2-year neurodevelopment among extremely preterm (EP) newborns. Study Design: Secondary analysis of the Preterm Erythropoietin Neuroprotection Trial evaluating time to r…
View article: Early Glycemic State and Outcomes of Neonates With Hypoxic-Ischemic Encephalopathy
Early Glycemic State and Outcomes of Neonates With Hypoxic-Ischemic Encephalopathy Open
OBJECTIVES In infants with hypoxic-ischemic encephalopathy (HIE), conflicting information on the association between early glucose homeostasis and outcome exists. We characterized glycemic profiles in the first 12 hours after birth and the…
View article: Neighborhood Opportunity and Vulnerability and Incident Asthma Among Children
Neighborhood Opportunity and Vulnerability and Incident Asthma Among Children Open
Background The extent to which physical and social attributes of neighborhoods play a role in childhood asthma remains understudied. Objective To examine associations of neighborhood-level opportunity and social vulnerability measures with…
View article: Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age
Contemporary Definitions of Infant Growth Failure and Neurodevelopmental and Behavioral Outcomes in Extremely Premature Infants at Two Years of Age Open
Introduction: The association of 2-year neurodevelopmental and behavioral outcomes with in-hospital or post-discharge growth failure (GF) using contemporary definitions for preterm infants is unknown. Methods In a secondary analysis of a p…
View article: Association of High-Dose Erythropoietin With Circulating Biomarkers and Neurodevelopmental Outcomes Among Neonates With Hypoxic Ischemic Encephalopathy
Association of High-Dose Erythropoietin With Circulating Biomarkers and Neurodevelopmental Outcomes Among Neonates With Hypoxic Ischemic Encephalopathy Open
Importance The ability to predict neurodevelopmental impairment (NDI) for infants diagnosed with hypoxic ischemic encephalopathy (HIE) is important for parental guidance and clinical treatment as well as for stratification of patients for …
View article: Health Care Utilization During the COVID-19 Pandemic Among Individuals Born Preterm
Health Care Utilization During the COVID-19 Pandemic Among Individuals Born Preterm Open
Importance Limited data exist on pediatric health care utilization during the COVID-19 pandemic among children and young adults born preterm. Objective To investigate differences in health care use related to COVID-19 concerns during the p…
View article: Assessment of Psychosocial and Neonatal Risk Factors for Trajectories of Behavioral Dysregulation Among Young Children From 18 to 72 Months of Age
Assessment of Psychosocial and Neonatal Risk Factors for Trajectories of Behavioral Dysregulation Among Young Children From 18 to 72 Months of Age Open
Importance Emotional and behavioral dysregulation during early childhood are associated with severe psychiatric, behavioral, and cognitive disorders through adulthood. Identifying the earliest antecedents of persisting emotional and behavi…
View article: Safety of High Dose Erythropoietin Used with Therapeutic Hypothermia as Treatment for Newborn Hypoxic-Ischemic Encephalopathy: Secondary Analysis of the HEAL Randomized Controlled Trial
Safety of High Dose Erythropoietin Used with Therapeutic Hypothermia as Treatment for Newborn Hypoxic-Ischemic Encephalopathy: Secondary Analysis of the HEAL Randomized Controlled Trial Open
View article: Patterns of Infections among Extremely Preterm Infants
Patterns of Infections among Extremely Preterm Infants Open
Infections remain a leading cause of neonatal death, especially among the extremely preterm infants. To evaluate the incidence, pathogenesis, and in-hospital outcomes associated with sepsis among hospitalized extremely preterm infants born…
View article: Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program
Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program Open
View article: Trends in Screen Time Use Among Children During the COVID-19 Pandemic, July 2019 Through August 2021
Trends in Screen Time Use Among Children During the COVID-19 Pandemic, July 2019 Through August 2021 Open
Importance The COVID-19 pandemic led to widespread lockdowns and school closures that may have affected screen time among children. Although restrictions were strongest early in the pandemic, it is unclear how screen time changed as the pa…
View article: Placental Histologic Abnormalities and 2-Year Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy
Placental Histologic Abnormalities and 2-Year Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy Open
Objective: We aimed to examine the association between placental abnormalities and neurodevelopmental outcomes in a multicenter cohort of newborn infants with hypoxic-ischemic encephalopathy (HIE) that underwent therapeutic h…
View article: Predicting 2-year neurodevelopmental outcomes in extremely preterm infants using graphical network and machine learning approaches
Predicting 2-year neurodevelopmental outcomes in extremely preterm infants using graphical network and machine learning approaches Open
Supported by the National Institute of Neurological Disorders and StrokeU01NS077953 and U01NS077955.
View article: Associations of Neighborhood Opportunity and Social Vulnerability With Trajectories of Childhood Body Mass Index and Obesity Among US Children
Associations of Neighborhood Opportunity and Social Vulnerability With Trajectories of Childhood Body Mass Index and Obesity Among US Children Open
Importance Physical and social neighborhood attributes may have implications for children’s growth and development patterns. The extent to which these attributes are associated with body mass index (BMI) trajectories and obesity risk from …
View article: Risk of seizures in neonates with hypoxic-ischemic encephalopathy receiving hypothermia plus erythropoietin or placebo
Risk of seizures in neonates with hypoxic-ischemic encephalopathy receiving hypothermia plus erythropoietin or placebo Open
View article: Prevalence and Risk Factors for Kidney Disease and Elevated BP in 2-Year-Old Children Born Extremely Premature
Prevalence and Risk Factors for Kidney Disease and Elevated BP in 2-Year-Old Children Born Extremely Premature Open
Background and objectives Extremely low gestational age neonates born 90th percentile for height, age, and sex. Results A total of 832 survived to 2 years, and 565 (68%) had at least one outcome measured. Overall, 297 (53%) had one abnorma…
View article: Trial of Erythropoietin for Hypoxic–Ischemic Encephalopathy in Newborns
Trial of Erythropoietin for Hypoxic–Ischemic Encephalopathy in Newborns Open
The administration of erythropoietin to newborns undergoing therapeutic hypothermia for hypoxic-ischemic encephalopathy did not result in a lower risk of death or neurodevelopmental impairment than placebo and was associated with a higher …
View article: Iron supplementation and the risk of bronchopulmonary dysplasia in extremely low gestational age newborns
Iron supplementation and the risk of bronchopulmonary dysplasia in extremely low gestational age newborns Open
View article: Mild hypoxic-ischemic encephalopathy (HIE): timing and pattern of MRI brain injury
Mild hypoxic-ischemic encephalopathy (HIE): timing and pattern of MRI brain injury Open
Background Mild hypoxic-ischemic encephalopathy (HIE) is increasingly recognized as a risk factor for neonatal brain injury. We examined the timing and pattern of brain injury in mild HIE. Methods This retrospective cohort study includes i…