Dennis Häckl
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Diagnosis and management of male hypogonadism in Germany Open
Optimizing the diagnosis, treatment, and monitoring of male hypogonadism in clinical practice could enhance the quality of life for affected individuals and reduce societal costs.
View article: Epidemiology, Health Care Resource Utilization, and Costs of Hemophilia A and B by Treatment Regimen: A Retrospective Analysis of German Claims Data from 2016 to 2021
Epidemiology, Health Care Resource Utilization, and Costs of Hemophilia A and B by Treatment Regimen: A Retrospective Analysis of German Claims Data from 2016 to 2021 Open
In Germany, hemophilia patients with a severe bleeding phenotype receive lifelong prophylactic treatment with intravenous concentrated factor VIII (FVIII) or IX (FIX) to prevent bleeding events. To assess the economic value of emerging tre…
Burden of COVID-19 in immunocompromised patients in Germany: a retrospective, observational Study on Health Insurance Data from 2021 to 2022 Open
Purpose Patients with COVID-19 and immunocompromising conditions are threatened with higher morbidity, mortality and a greater economic burden than immunocompetent persons due to an inadequate immune response to infection and vaccination. …
Costs and Outcomes of Clostridioides difficile Infections in Germany: A Retrospective Health Claims Data Analysis Open
CDI in Germany is associated with a high clinical and economic burden, including significantly higher mortality, costs, and healthcare resource utilization, in patients with CDI versus their matched patients without CDI. This has important…
Prevalence of obesity and cardiovascular disease in adults with type 2 diabetes and use of diabetes medication in Germany: A claims data study Open
Aims To identify the prevalence of cardiovascular disease (CVD) and obesity in patients with type 2 diabetes (T2D) in Germany and to evaluate if antidiabetic treatment patterns varied by comorbidity status. Materials and Methods Patients w…
Epidemiology of paediatric chronic heart failure in Germany—A population‐based analysis Open
Aims Paediatric chronic heart failure (CHF) is associated with significant morbidity. The aim of this study was to describe paediatric CHF epidemiology in Germany. Methods and results This is a retrospective cross‐sectional analysis of ano…
The socio‐economic burden of H1‐antihistamine‐refractory chronic spontaneous urticaria in Germany Open
Background and Study Aim Data from the AWARE study (A Worldwide Antihistamine‐Refractory chronic urticaria patient Evaluation) illustrate a substantial disease burden in German patients with H1‐antihistamine (‐H1‐AH)‐refractory chronic spo…
Epidemiology and treatment of pain associated with osteoarthritis of the knee in Germany: A retrospective health claims data analysis Open
The number of patients with knee OA in Germany is steadily rising, along with an increasing number of surgical interventions, especially knee replacement. Time until first surgery and knee replacement is relatively short, even for newly di…
Agreement between self-reports and statutory health insurance claims data on healthcare utilization in patients with mental disorders Open
Background Data on resource use are frequently required for healthcare assessments. Studies on healthcare utilization (HCU) in individuals with mental disorders have analyzed both self-reports and administrative data. Source of data may af…
View article: Self-reported versus administrative data records: implications for assessing healthcare resource utilization of mental disorders
Self-reported versus administrative data records: implications for assessing healthcare resource utilization of mental disorders Open
Background : Data on resourceuse are frequently required for health economic evaluation. Studies on health care utilization in individuals with mental disorders have analyzed both self-reports and administrative data, each of which with st…
Lengths of inpatient stay and sick leave of patients with mental diseases: disorder-specific effects of flexible and integrated treatment programs in Germany Open
Mental disorders pose a worldwide growing public health burden. One of the major challenges for healthcare systems remains to respond to the need of patients with mental disorders for continuous and flexible treatment. The EVA64 study eval…
Lichen planus in Germany – epidemiology, treatment, and comorbidity. A retrospective claims data analysis Open
Summary Background and objectives Lichen planus (LP) is a chronic inflammatory skin disease and is a major burden for affected patients. However, data on this condition are scarce. This study aims to expand the knowledge on the epidemiolog…
Pneumococcal vaccination rates in immunocompromised patients in Germany: A retrospective cohort study to assess sequential vaccination rates and changes over time Open
Background Pneumococcal vaccination is recommended by the German Standing Committee on Vaccination (STIKO) for infants, elderly 60+ years and patients at risk. In 2016, a sequential pneumococcal vaccination schedule (conjugate vaccine foll…
Glycemic Variability Is Associated With All-Cause Mortality In COVID-19 Patients With ARDSFindings From The COVAS Cohort Open
There is high mortality among intensive care unit (ICU) patients with acute respiratory distress syndrome (ARDS) caused by coronavirus disease 19 (COVID-19). Important factors for COVID-19 mortality are diabetes status and elevated fasting…
Population-based incidence and mortality of community-acquired pneumonia in Germany Open
Background Little information on the current burden of community-acquired pneumonia (CAP) in adults in Germany is available. Methods We conducted a retrospective cohort study using a representative healthcare claims database of approx. 4 m…
Multiperspective and Multimethod Evaluation of Flexible and Integrative Psychiatric Care Models in Germany: Study Protocol of a Prospective, Controlled Multicenter Observational Study (PsychCare) Open
Background: New cross-sectoral mental health care models have been initiated in Germany to overcome the fragmentation of the German health care system. Starting in 2013, flexible and integrative psychiatric care model projects according to…
Early risk markers for severe clinical course and fatal outcome in German patients with COVID-19 Open
Background Some patients with Corona Virus Disease 2019 (COVID-19) develop a severe clinical course with acute respiratory distress syndrome (ARDS) and fatal outcome. Clinical manifestations and biomarkers in early stages of disease with r…
Vaccination rate and adherence of tick-borne encephalitis vaccination in Germany Open
While there was an overall low vaccination uptake and a discrepancy between areas of high vs. low TBE risk, this study also indicates a concerning decline in vaccination compliance. Vaccinating physicians should address the importance of a…
Effectiveness of Global Treatment Budgets for Patients With Mental Disorders—Claims Data Based Meta-Analysis of 13 Controlled Studies From Germany Open
Background: Individuals with mental disorders need continuous and efficient collaboration between different sectors of care. In 2012, a new law in Germany enabled the implementation of novel budgets in psychiatry (flexible and integrated t…
Clinical and economic burden of invasive meningococcal disease: Evidence from a large German claims database Open
IMD resulted in severe complications and sequelae and was associated with extensive costs and increased healthcare resource use in Germany, especially in the first year after IMD diagnosis and due the IMD-related hospitalization.
Effectiveness of cross-sectoral treatment models for patients with mental disorders - meta-analysis of 13 controlled studies from Germany Open
Background Individuals with mental disorders demand for a continuous and efficient collaboration between different sectors of care. In 2012, a new law in Germany enabled the implementation of cross-sectoral and patient-centered treatment m…
Pneumococcal vaccination rates in immunocompromised patients—A cohort study based on claims data from more than 200,000 patients in Germany Open
Although these vulnerable patients need protection most, our study suggests that the overall pnc-VR after a first episode of a high-risk condition for pneumococcal disease is very low and vaccination is far too late. To prevent pneumococca…