Dennis Kätzel
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View article: Cav2.3 channels stimulate in vivo burst activity of vulnerable dopamine neurons and are elevated in Parkinson’s disease
Cav2.3 channels stimulate in vivo burst activity of vulnerable dopamine neurons and are elevated in Parkinson’s disease Open
The progressive degeneration of dopamine neurons (DAN) in the Substantia nigra (SN) is a hallmark of Parkinson’s disease (PD). R-type voltage gated Ca2+ channels (Cav2.3) contribute to activity-related Ca2+-influx in SN DAN which is linked…
View article: Neural effects of dopaminergic compounds revealed by multi-site electrophysiology and interpretable machine-learning
Neural effects of dopaminergic compounds revealed by multi-site electrophysiology and interpretable machine-learning Open
Background Neuropsychopharmacological compounds may exert complex brain-wide effects due to an anatomically and genetically broad expression of their molecular targets and indirect effects via interconnected brain circuits. Electrophysiolo…
View article: Editorial: Reviews in psychiatry 2023: schizophrenia
Editorial: Reviews in psychiatry 2023: schizophrenia Open
Keywords: schizophrenia, biomarkers, therapeutic targets, systematic reviews, psychosocial functioning, psychological therapy, symptom domains, pharmacological therapy
View article: Excitatory neurons of the anterior cingulate cortex encode chosen actions and their outcomes rather than cognitive state
Excitatory neurons of the anterior cingulate cortex encode chosen actions and their outcomes rather than cognitive state Open
The anterior cingulate cortex (ACC) causally influences cognitive control of goal-directed behaviour. However, it is unclear whether ACC directly encodes cognitive variables like attention or impulsivity, or implements goal-directed action…
View article: Control of sustained attention and impulsivity by Gq-protein signalling in parvalbumin interneurons of the anterior cingulate cortex
Control of sustained attention and impulsivity by Gq-protein signalling in parvalbumin interneurons of the anterior cingulate cortex Open
The anterior cingulate cortex (ACC) has been implicated in attention deficit hyperactivity disorder (ADHD). More specifically, an appropriate balance of excitatory and inhibitory activity in the ACC may be critical for the control of impul…
View article: Open-MAC: A low-cost open-source motorized commutator for electro- and opto-physiological recordings in freely moving rodents
Open-MAC: A low-cost open-source motorized commutator for electro- and opto-physiological recordings in freely moving rodents Open
In vivo electro- and optophysiology experiments in rodents reveal the neural mechanisms underlying behavior and brain disorders but mostly involve a cable connection between an implant in the animal and an external recording device. Standa…
View article: Open-MAC: A low-cost open-source motorized commutator for electro- and opto-physiological recordings in freely moving rodents
Open-MAC: A low-cost open-source motorized commutator for electro- and opto-physiological recordings in freely moving rodents Open
Design files for an open-source motorized all-in-one commutator (Open-MAC). These designs are released under the GNU General Public Licence v2.0 or later. The design files published here can also be found on GitHub, where future design cha…
View article: Open-MAC: A low-cost open-source motorized commutator for electro- and opto-physiological recordings in freely moving rodents
Open-MAC: A low-cost open-source motorized commutator for electro- and opto-physiological recordings in freely moving rodents Open
Design files for an open-source motorized all-in-one commutator (Open-MAC). These designs are released under the GNU General Public Licence v2.0 or later. The design files published here can also be found on GitHub, where future design cha…
View article: Open-MAC: A low-cost open-source motorized commutator for electro- and opto-physiological recordings in freely moving rodents
Open-MAC: A low-cost open-source motorized commutator for electro- and opto-physiological recordings in freely moving rodents Open
Design files for an open-source motorized all-in-one commutator (Open-MAC).
View article: Chronic N-acetylcysteine treatment improves anhedonia and cognition in a mouse model of the schizophrenia prodrome
Chronic N-acetylcysteine treatment improves anhedonia and cognition in a mouse model of the schizophrenia prodrome Open
Schizophrenia is a severe psychiatric disorder whose neurodevelopmental pathogenesis includes a prodromal phase before its diagnostically decisive—namely psychotic—symptoms are present. This prodrome is characterized by cognitive and affec…
View article: Open-source, Python-based, hardware and software for controlling behavioural neuroscience experiments
Open-source, Python-based, hardware and software for controlling behavioural neuroscience experiments Open
Laboratory behavioural tasks are an essential research tool. As questions asked of behaviour and brain activity become more sophisticated, the ability to specify and run richly structured tasks becomes more important. An increasing focus o…
View article: Highly task-specific and distributed neural connectivity in working memory revealed by single-trial decoding in mice and humans
Highly task-specific and distributed neural connectivity in working memory revealed by single-trial decoding in mice and humans Open
Working memory (WM), the capacity to briefly and intentionally maintain mental items, is key to successful goal-directed behaviour and impaired in a range of psychiatric disorders. To date, several brain regions, connections, and types of …
View article: pyControl: Open source, Python based, hardware and software for controlling behavioural neuroscience experiments
pyControl: Open source, Python based, hardware and software for controlling behavioural neuroscience experiments Open
Laboratory behavioural tasks are an essential research tool. As questions asked of behaviour and brain activity become more sophisticated, the ability to specify and run richly structured tasks becomes more important. An increasing focus o…
View article: Lack of redundancy between electrophysiological measures of long-range neuronal communication
Lack of redundancy between electrophysiological measures of long-range neuronal communication Open
Background Communication between brain areas has been implicated in a wide range of cognitive and emotive functions and is impaired in numerous mental disorders. In rodent models, various metrics have been used to quantify inter-regional n…
View article: Additional file 1 of Lack of redundancy between electrophysiological measures of long-range neuronal communication
Additional file 1 of Lack of redundancy between electrophysiological measures of long-range neuronal communication Open
Additional file 1: Contains four tables, Table S1-S4, that state the results of pairwise Spearman correlations between all metrics analysed in this study for a given connection. The first number in each cell states Spearman’s rho, the seco…
View article: Hippocampal Hyperactivity as a Druggable Circuit-Level Origin of Aberrant Salience in Schizophrenia
Hippocampal Hyperactivity as a Druggable Circuit-Level Origin of Aberrant Salience in Schizophrenia Open
The development of current neuroleptics was largely aiming to decrease excessive dopaminergic signaling in the striatum. However, the notion that abnormal dopamine creates psychotic symptoms by causing an aberrant assignment of salience th…
View article: Lack of redundancy between electrophysiological measures of long-range neuronal communication
Lack of redundancy between electrophysiological measures of long-range neuronal communication Open
Communication between brain areas has been implicated in a wide range of cognitive and emotive functions and is impaired in numerous mental disorders. In rodent models, various functional connectivity metrics have been used to quantify int…
View article: Can N-Methyl-D-Aspartate Receptor Hypofunction in Schizophrenia Be Localized to an Individual Cell Type?
Can N-Methyl-D-Aspartate Receptor Hypofunction in Schizophrenia Be Localized to an Individual Cell Type? Open
Hypofunction of N-methyl-D-aspartate glutamate receptors (NMDARs), whether caused by endogenous factors like auto-antibodies or mutations, or by pharmacological or genetic manipulations, produces a wide variety of deficits which overlap wi…
View article: Operant Assessment of DMTP Spatial Working Memory in Mice
Operant Assessment of DMTP Spatial Working Memory in Mice Open
Working memory (WM) is required to bridge the time between the moment of sensory perception and the usage of the acquired information for subsequent actions. Its frequent and pharmacoresistent impairment in mental health disorders urges th…
View article: Hippocampal–prefrontal coherence mediates working memory and selective attention at distinct frequency bands and provides a causal link between schizophrenia and its risk gene GRIA1
Hippocampal–prefrontal coherence mediates working memory and selective attention at distinct frequency bands and provides a causal link between schizophrenia and its risk gene GRIA1 Open
Increased fronto-temporal theta coherence and failure of its stimulus-specific modulation have been reported in schizophrenia, but the psychological correlates and underlying neural mechanisms remain elusive. Mice lacking the putative schi…
View article: Gene-Environment Interaction in a Conditional NMDAR-Knockout Model of Schizophrenia
Gene-Environment Interaction in a Conditional NMDAR-Knockout Model of Schizophrenia Open
Interactions between genetic and environmental risk factors take center stage in the pathology of schizophrenia. We assessed if the stressor of reduced environmental enrichment applied in adulthood provokes deficits in the positive, negati…
View article: Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity
Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity Open
Elevated activity at the output stage of the anterior hippocampus has been described as a physiological endophenotype of schizophrenia, and its development maps onto the transition from the prodromal to the psychotic state. Interventions t…