Danielle Benedict Sacdalan
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View article: Effects of Structured Exercise Programs on Self-Reported Health-Related Quality of Life in Patients with Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Effects of Structured Exercise Programs on Self-Reported Health-Related Quality of Life in Patients with Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
Current treatments for metastatic non-small cell lung cancer (NSCLC) have improved survival but remain non-curative, primarily aiming to control disease and to extend life. Structured exercise has demonstrated clinical and quality-of-life …
View article: Identifying Novel Germline Mutations and Copy Number Variations in Patients With SCLC
Identifying Novel Germline Mutations and Copy Number Variations in Patients With SCLC Open
Our study identifies novel germline alterations, including a CNV, and provides additional evidence that germline factors could be important contributing factors to the development of SCLC.
View article: Plasma Cell-Free Tumor Methylome as a Biomarker in Solid Tumors: Biology and Applications
Plasma Cell-Free Tumor Methylome as a Biomarker in Solid Tumors: Biology and Applications Open
DNA methylation is a fundamental mechanism of epigenetic control in cells and its dysregulation is strongly implicated in cancer development. Cancers possess an extensively hypomethylated genome with focal regions of hypermethylation at CP…
View article: Cross-sectional Cranial CT Imaging Findings and Patterns in Clinically Diagnosed COVID-19 Cases in a Tertiary Referral Center
Cross-sectional Cranial CT Imaging Findings and Patterns in Clinically Diagnosed COVID-19 Cases in a Tertiary Referral Center Open
This study sheds light on the radiological patterns of CNS involvement in COVID-19 patients, highlighting frequent frontal lobe involvement possibly attributed to hypercoagulability and endotheliitis. Further research with larger sample si…
View article: Pre- and Post-operative Parameters among Patients Undergoing Pre-operative Embolization of Meningioma: a Tertiary Referral Center Experience
Pre- and Post-operative Parameters among Patients Undergoing Pre-operative Embolization of Meningioma: a Tertiary Referral Center Experience Open
In summary, this study represents a significant endeavor to elucidate factors influencing meningioma outcomes following pre-operative embolization. Despite limitations regarding patient numbers, our study offers valuable insights into oper…
View article: P078: Identification of novel germline mutations and copy-number variations in patients with small cell lung cancer
P078: Identification of novel germline mutations and copy-number variations in patients with small cell lung cancer Open
Small cell lung cancer (SCLC) is a highly aggressive cancer primarily associated with tobacco smoking. Recent findings have identified germline alterations that challenged the assumption that solely tobacco exposure causes SCLC. Currently,…
View article: Cell-free DNA methylation-defined prognostic subgroups in small-cell lung cancer identified by leukocyte methylation subtraction
Cell-free DNA methylation-defined prognostic subgroups in small-cell lung cancer identified by leukocyte methylation subtraction Open
View article: Choosing Wisely Philippines: ten low-value or harmful practices that should be avoided in cancer care
Choosing Wisely Philippines: ten low-value or harmful practices that should be avoided in cancer care Open
The Choosing Wisely Philippines campaign is an initiative that identifies low-value or potentially harmful practices that are relevant to patients with cancer in the Philippines. The main purpose of these initiatives is to facilitate quali…
View article: Cell-free Tumor Methylome Analysis of Small Cell Lung Cancer Patients Identifies Subgroups with Prognostic Associations
Cell-free Tumor Methylome Analysis of Small Cell Lung Cancer Patients Identifies Subgroups with Prognostic Associations Open
Introduction Small cell lung cancer (SCLC) is a highly aggressive type of cancer with a high risk of recurrence. The SCLC methylome may yield biologic insight but is understudied due to difficulty in acquiring primary patient tissue. Here,…
View article: A reduced dosing strategy can work for Alectinib in ALK rearranged non small cell lung cancer
A reduced dosing strategy can work for Alectinib in ALK rearranged non small cell lung cancer Open
View article: The role of the medical oncologist in the holistic care of patients with cancer in the Philippines
The role of the medical oncologist in the holistic care of patients with cancer in the Philippines Open
In the past decade, cancer care in the Philippines has advanced in response to the complex heterogeneity inherent to the disease and the constantly increasing number of patients. Central to this development is the increased awareness and u…
View article: The Association Between Inflammation and Immunosuppression: Implications for ICI Biomarker Development
The Association Between Inflammation and Immunosuppression: Implications for ICI Biomarker Development Open
Evasion of immune destruction is considered one of the hallmarks of cancer. Chronic inflammation can enable immune escape by suppressing immune surveillance and permitting the development of tumors and creating a tumor microenvironment tha…
View article: Clinicopathologic Factors Associated with Mismatch Repair Status Among Filipino Patients with Young-Onset Colorectal Cancer
Clinicopathologic Factors Associated with Mismatch Repair Status Among Filipino Patients with Young-Onset Colorectal Cancer Open
This is the first attempt to perform mismatch repair testing among young-onset colorectal cancer patients in the Philippines and to gather data on their clinicopathologic characteristics. However, the limited sample size precludes conclusi…
View article: A systematic review and meta-analysis on the efficacy and safety of metformin as adjunctive therapy among women with metastatic breast cancer
A systematic review and meta-analysis on the efficacy and safety of metformin as adjunctive therapy among women with metastatic breast cancer Open
View article: Empathy
Empathy Open
View article: Revisiting a lower starting dose of alectinib in ALK-Positive non-small cell lung cancer
Revisiting a lower starting dose of alectinib in ALK-Positive non-small cell lung cancer Open
We present here a case of ALK-positive lung adenocarcinoma that has been started on Alectinib. Treatment has been initiated at the recommended initial dose, but it subsequently required a dose adjustment following adverse drug events. Alec…
View article: 292P Shared decision-making at the cancer institute adult outpatient clinics of a tertiary hospital in the Philippines: A cross sectional study
292P Shared decision-making at the cancer institute adult outpatient clinics of a tertiary hospital in the Philippines: A cross sectional study Open
View article: Patterns of Biomarker Use in Cancer Treatment Among Medical Oncologists in the Philippines
Patterns of Biomarker Use in Cancer Treatment Among Medical Oncologists in the Philippines Open
PURPOSE Several factors affect how medical oncologists in the Philippines use biomarkers in real-world practice. This study describes patterns of biomarker testing for the management of breast, colorectal, and lung cancers among medical on…
View article: Updated general recommendations in cancer management during the COVID-19 pandemic in the Philippines
Updated general recommendations in cancer management during the COVID-19 pandemic in the Philippines Open
In May 2020, the Philippine Society of Medical Oncology published its initial recommendations on the treatment of cancer patients during the SARS-Cov-2 pandemic. The objective of this update is to provide answers to the questions pertainin…
View article: Medical oncology care amidst the COVID-19 pandemic at the National University Hospital in the Philippines
Medical oncology care amidst the COVID-19 pandemic at the National University Hospital in the Philippines Open
COVID-19 has abruptly and radically changed the landscape of cancer care delivery throughout the world, including the Philippines. The Philippine General Hospital is the academic hospital of the University of the Philippines. Its cancer ce…
View article: Fan-on-Face Therapy in Relieving Dyspnea of Adult Terminally Ill Cancer Patients: A Meta-Analysis
Fan-on-Face Therapy in Relieving Dyspnea of Adult Terminally Ill Cancer Patients: A Meta-Analysis Open
Introduction Dyspnea is often encountered in terminally ill cancer patients and is attributed to multiple factors. The use of fan-on-face therapy is a nonpharmacologic adjunct treatment for adult cancer patients suffering from dyspnea at t…
View article: Treatment of cancer patients during the COVID-19 pandemic in the Philippines
Treatment of cancer patients during the COVID-19 pandemic in the Philippines Open
The COVID-19 pandemic has caused disruptions in cancer care around the world due to logistical and psychosocial reasons. This paper was written with the primary objective of providing a guide for medical oncologists in addressing concerns …
View article: Treatment Outcomes of Patients With Colorectal Cancer Enrolled in a Comprehensive Benefits Program of the National Insurance System in the Philippines: Data From the Pilot Site
Treatment Outcomes of Patients With Colorectal Cancer Enrolled in a Comprehensive Benefits Program of the National Insurance System in the Philippines: Data From the Pilot Site Open
PURPOSE Cancer treatment causes significant financial burden, especially in developing countries such as the Philippines. This led the Philippine Department of Health to create the Z-Package colorectal cancer benefit program, an insurance …
View article: COVID-19 in cancer patients can be challenging to screen in a resource limited setting
COVID-19 in cancer patients can be challenging to screen in a resource limited setting Open
During this COVID-19 pandemic, patients with symptoms such as fever, cough, sore throat, and coryza were advised to have RT-PCR testing for SARS-CoV-2 infection. We described here an elderly female with chronic lymphocytic leukemia, who pr…
View article: Giant cell tumor of soft tissue of the nasopharynx: A case report
Giant cell tumor of soft tissue of the nasopharynx: A case report Open
View article: Prognostic value of C-reactive protein, albumin and C-reactive protein to albumin ratio in small cell lung cancer: A meta-analysis
Prognostic value of C-reactive protein, albumin and C-reactive protein to albumin ratio in small cell lung cancer: A meta-analysis Open
View article: Treatment outcomes of colorectal cancer patients enrolled in a comprehensive benefits program of the National Health Insurance System in the Philippines: Data from the program pilot site
Treatment outcomes of colorectal cancer patients enrolled in a comprehensive benefits program of the National Health Insurance System in the Philippines: Data from the program pilot site Open
View article: Prognostic significance of serum biomarkers in small cell lung cancer: A meta-analysis and systematic review
Prognostic significance of serum biomarkers in small cell lung cancer: A meta-analysis and systematic review Open
View article: PREDICTIVE MARKERS FOR EARLY DETECTION OF HAZARDOUS EFFECTS OF NANOMATERIALS
PREDICTIVE MARKERS FOR EARLY DETECTION OF HAZARDOUS EFFECTS OF NANOMATERIALS Open
View article: PROGNOSTIC SIGNIFICANCE OF HEMATOLOGIC BIOMARKERS IN SMALL CELL LUNG CANCER: A META-ANALYSIS AND SYSTEMATIC REVIEW
PROGNOSTIC SIGNIFICANCE OF HEMATOLOGIC BIOMARKERS IN SMALL CELL LUNG CANCER: A META-ANALYSIS AND SYSTEMATIC REVIEW Open