Dennis M. Hedderich
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View article: The Expertise Paradox: Who Benefits from LLM-Assisted Brain MRI Differential Diagnosis?
The Expertise Paradox: Who Benefits from LLM-Assisted Brain MRI Differential Diagnosis? Open
Purpose To evaluate how reader experience influences the diagnostic benefit from LLM assistance in brain MRI differential diagnosis. Materials and Methods Neuroradiologists (n = 4), radiology residents (n = 4), and neurology/neurosurgery r…
View article: Diffusion Bridge Networks Simulate Clinical-grade PET from MRI for Dementia Diagnostics
Diffusion Bridge Networks Simulate Clinical-grade PET from MRI for Dementia Diagnostics Open
Positron emission tomography (PET) with 18F-Fluorodeoxyglucose (FDG) is an established tool in the diagnostic workup of patients with suspected dementing disorders. However, compared to the routinely available magnetic resonance imaging (M…
View article: Radiation-free cochlear implant position estimation in pediatric patients using impedance telemetry
Radiation-free cochlear implant position estimation in pediatric patients using impedance telemetry Open
View article: Febrile Infection-Related Epilepsy Syndrome (FIRES) in a Young Adult: A Case Report Highlighting Advanced Neuroimaging
Febrile Infection-Related Epilepsy Syndrome (FIRES) in a Young Adult: A Case Report Highlighting Advanced Neuroimaging Open
View article: Individualized mapping of aberrant cortical thickness via stochastic cortical self-reconstruction
Individualized mapping of aberrant cortical thickness via stochastic cortical self-reconstruction Open
Understanding individual differences in cortical structure is key to advancing diagnostics in neurology and psychiatry. Reference models aid in detecting aberrant cortical thickness, yet site-specific biases limit their direct application …
View article: Claustrum volume in humans – lifespan trajectory and effect of age, hemisphere, and sex
Claustrum volume in humans – lifespan trajectory and effect of age, hemisphere, and sex Open
The human claustrum is a bilateral, thin, irregularly shaped gray matter structure located between the striatum and insula. While previous research demonstrated the effect of distinct medical conditions, such as prematurity, schizophrenia,…
View article: Heterogeneous, temporally consistent, and plastic brain development after preterm birth
Heterogeneous, temporally consistent, and plastic brain development after preterm birth Open
The current view of neurodevelopment after preterm birth presents a strong paradox: diverse neurocognitive outcomes suggest heterogeneous neurodevelopment, yet numerous brain imaging studies focusing on average dysmaturation imply largely …
View article: Evaluating large language model-generated brain MRI protocols: performance of GPT4o, o3-mini, DeepSeek-R1 and Qwen2.5-72B
Evaluating large language model-generated brain MRI protocols: performance of GPT4o, o3-mini, DeepSeek-R1 and Qwen2.5-72B Open
Objectives To evaluate the potential of LLMs to generate sequence-level brain MRI protocols. Materials and methods This retrospective study employed a dataset of 150 brain MRI cases derived from local imaging request forms. Reference proto…
View article: Increased coupling between global grey matter and CSF-derived fMRI signal in young adults after partial sleep deprivation – evidence from the sleepy brain study
Increased coupling between global grey matter and CSF-derived fMRI signal in young adults after partial sleep deprivation – evidence from the sleepy brain study Open
Evidence indicates that brain waste clearance happens more efficiently during sleep. Recent studies suggest that the correlation, i.e., coupling, between the cortical grey matter (gGM) blood oxygenation level-dependent signal and cerebrosp…
View article: Lower hippocampal volumes at baseline are associated with higher volume loss in healthy elderly
Lower hippocampal volumes at baseline are associated with higher volume loss in healthy elderly Open
Introduction Hippocampal volume loss occurs physiologically with age, but an accelerated rate of volume loss is linked to neurodegenerative diseases. While evidence suggests that cross-sectional study designs tend to underestimate hippocam…
View article: LLM Reasoning Does Not Protect Against Clinical Cognitive Biases - An Evaluation Using BiasMedQA
LLM Reasoning Does Not Protect Against Clinical Cognitive Biases - An Evaluation Using BiasMedQA Open
Background Cognitive biases are an important source of clinical errors. Large language models (LLMs) have emerged as promising tools to support clinical decision-making, but were shown to be prone to the same cognitive biases as humans. Re…
View article: Data extraction from free-text stroke CT reports using GPT-4o and Llama-3.3-70B: the impact of annotation guidelines
Data extraction from free-text stroke CT reports using GPT-4o and Llama-3.3-70B: the impact of annotation guidelines Open
Background To evaluate the impact of an annotation guideline on the performance of large language models (LLMs) in extracting data from stroke computed tomography (CT) reports. Methods The performance of GPT-4o and Llama-3.3-70B in extract…
View article: Boosting LLM-assisted diagnosis: 10-minute LLM tutorial elevates radiology residents’ performance in brain MRI interpretation
Boosting LLM-assisted diagnosis: 10-minute LLM tutorial elevates radiology residents’ performance in brain MRI interpretation Open
View article: Total cerebral blood volume changes drive macroscopic cerebrospinal fluid flux in humans
Total cerebral blood volume changes drive macroscopic cerebrospinal fluid flux in humans Open
In the mammalian brain, the directed motion of cerebrospinal fluid (CSF-flux) is instrumental in the distribution and removal of solutes. Changes in total cerebral blood volume (CBV) have been hypothesized to drive CSF-flux. We tested this…
View article: Evaluating Large Language Model-Generated Brain MRI Protocols: Performance of GPT4o, o3-mini, DeepSeek-R1 and Qwen2.5-72B
Evaluating Large Language Model-Generated Brain MRI Protocols: Performance of GPT4o, o3-mini, DeepSeek-R1 and Qwen2.5-72B Open
Purpose To evaluate the potential of LLMs to generate sequence-level brain MRI protocols. Methods A dataset of 150 brain MRI cases was derived from imaging request forms obtained from the local institution. For each case, a reference MRI p…
View article: Human-AI collaboration in large language model-assisted brain MRI differential diagnosis: a usability study
Human-AI collaboration in large language model-assisted brain MRI differential diagnosis: a usability study Open
View article: The impact of socio-environmental factors on brain structure over the early life course of preterm-born individuals - A systematic review
The impact of socio-environmental factors on brain structure over the early life course of preterm-born individuals - A systematic review Open
Socio-environmental factors are associated with changes in grey and white matter in the brain, especially in the limbic system and associative areas. These findings underscore the influence of early environments on preterm-born brain devel…
View article: Automation bias in AI-assisted detection of cerebral aneurysms on time-of-flight MR angiography
Automation bias in AI-assisted detection of cerebral aneurysms on time-of-flight MR angiography Open
View article: Benchmarking the diagnostic performance of open source LLMs in 1933 Eurorad case reports
Benchmarking the diagnostic performance of open source LLMs in 1933 Eurorad case reports Open
View article: Domain‐Specific Prediction of Clinical Progression in Parkinson's Disease Using the Mosaic Approach
Domain‐Specific Prediction of Clinical Progression in Parkinson's Disease Using the Mosaic Approach Open
Purpose : Due to the highly individualized clinical manifestation of Parkinson's disease (PD), personalized patient care may require domain‐specific assessment of neurological disability. Evidence from magnetic resonance imaging (MRI) stud…
View article: Heterogeneous, temporally consistent, and plastic brain development after preterm birth
Heterogeneous, temporally consistent, and plastic brain development after preterm birth Open
The current view of neurodevelopment after preterm birth presents a strong paradox: diverse neurocognitive outcomes suggest heterogeneous neurodevelopment, yet numerous brain imaging studies focusing on average dysmaturation imply largely …
View article: MLV$^2$-Net: Rater-Based Majority-Label Voting for Consistent Meningeal Lymphatic Vessel Segmentation
MLV$^2$-Net: Rater-Based Majority-Label Voting for Consistent Meningeal Lymphatic Vessel Segmentation Open
Meningeal lymphatic vessels (MLVs) are responsible for the drainage of waste products from the human brain. An impairment in their functionality has been associated with aging as well as brain disorders like multiple sclerosis and Alzheime…
View article: Neurocognitive dysfunction in adolescents with recent onset major depressive disorder: a cross-sectional comparative study
Neurocognitive dysfunction in adolescents with recent onset major depressive disorder: a cross-sectional comparative study Open
View article: Human Claustrum Connections: Robust In Vivo Detection by <scp>DWI</scp>‐Based Tractography in Two Large Samples
Human Claustrum Connections: Robust In Vivo Detection by <span>DWI</span>‐Based Tractography in Two Large Samples Open
Despite substantial neuroscience research in the last decade revealing the claustrum's prominent role in mammalian forebrain organization, as evidenced by its extraordinarily widespread connectivity pattern, claustrum studies in humans are…
View article: Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Long-term outcome studies, developmental care, palliative care, ethical dilemmas, and challenging clinical scenarios in neonatal neurology
Proceedings of the 15 <sup>th</sup> International Newborn Brain Conference: Long-term outcome studies, developmental care, palliative care, ethical dilemmas, and challenging clinical scenarios in neonatal neurology Open
BACKGROUND: Preterm birth is associated with significant risks for long-term impairments in brain structure and cognitive functions (1). At the microscopic level, the transient inflammatory and hypoxic-ischemic events occurring during prem…
View article: Consistently lower volumes across thalamus nuclei in very premature-born adults
Consistently lower volumes across thalamus nuclei in very premature-born adults Open
Lasting thalamus volume reduction after preterm birth is a prominent finding. However, whether thalamic nuclei volumes are affected differentially by preterm birth and whether nuclei aberrations are relevant for cognitive functioning remai…
View article: Uncovering genetic mimics in multiple sclerosis: A single-center clinical exome sequencing study
Uncovering genetic mimics in multiple sclerosis: A single-center clinical exome sequencing study Open
Background Multiple sclerosis (MS) shares clinical/radiological features with several monogenic diseases that can mimic MS. Objective We aimed to determine if exome sequencing can identify monogenic diseases in patients diagnosed with MS a…
View article: Resolving spatial response heterogeneity in glioblastoma
Resolving spatial response heterogeneity in glioblastoma Open
View article: Automation Bias in AI-Assisted Detection of Cerebral Aneurysms on Time-of-Flight MR-Angiography
Automation Bias in AI-Assisted Detection of Cerebral Aneurysms on Time-of-Flight MR-Angiography Open
Background AI systems have the potential to support in detecting cerebral aneurysms. Yet, the role of automation bias (inclination of humans to overly rely on automated decision-making systems) in AI-assisted cerebral aneurysm detection re…
View article: PASTA: Pathology-Aware MRI to PET Cross-Modal Translation with Diffusion Models
PASTA: Pathology-Aware MRI to PET Cross-Modal Translation with Diffusion Models Open
Positron emission tomography (PET) is a well-established functional imaging technique for diagnosing brain disorders. However, PET's high costs and radiation exposure limit its widespread use. In contrast, magnetic resonance imaging (MRI) …