Explanipedia

Cathepsin-D and outcomes in peripartum cardiomyopathy: Results from IPAC Open

Vincenzo B. Polsinelli, Karen Hanley‐Yanez, Charles F. McTiernan, Kalgi Modi, Jennifer Haythe , et al. · 2024

CMR and adverse clinical outcomes in peripartum cardiomyopathy Open

Agnes Koczo, Deeksha Acharya, Benay Özbay, Rami Alharethi, Michael M. Givertz , et al. · 2024

Impact of cannabidiol on myocardial recovery in patients with acute myocarditis: Rationale & design of the ARCHER trial Open

Dennis M. McNamara, Leslie T. Cooper, Yaron Arbel, Arvind Bhimaraj, Edimar Alcides Bocchi , et al. · 2024

Aims Acute myocarditis, although a rare disease, can be associated with sudden cardiac death or the need for transplantation in both children and young adults. To date, there is no definitive evidence to support the routine use of immunosu…

Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human Open

Jason D. Roh, Claire Castro, Andy Yu, Sarosh Rana, Sajid Shahul , et al. · 2024

Peripartum cardiomyopathy (PPCM) is an idiopathic form of pregnancy-induced heart failure associated with preeclampsia. Circulating factors in late pregnancy are thought to contribute to both diseases, suggesting a common underlying pathop…

Impact of post-transplant stroke and subsequent functional independence on outcomes following heart transplantation under the 2018 United States heart allocation system Open

Yeahwa Hong, Lauren V. Huckaby, Nicholas R. Hess, Luke A. Ziegler, Gavin Hickey , et al. · 2024

Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension Open

Yi‐Yin Tai, Qiujun Yu, Ying Tang, Wei Sun, Neil J. Kelly , et al. · 2024

Hypoxic reprogramming of vasculature relies on genetic, epigenetic, and metabolic circuitry, but the control points are unknown. In pulmonary arterial hypertension (PAH), a disease driven by hypoxia inducible factor (HIF)–dependent vascula…

CMR and Clinical Outcomes in Peripartum Cardiomyopathy: Moving Beyond LVEF Open

Agnes Koczo, Deeksha Acharya, Benay Özbay, Dennis M. McNamara, Timothy C. Wong · 2024

An individualized Bayesian method for estimating genomic variants of hypertension Open

Md Asad Rahman, Chunhui Cai, Na Bo, Dennis M. McNamara, Ying Ding , et al. · 2023

Background Genomic variants of the disease are often discovered nowadays through population-based genome-wide association studies (GWAS). Identifying genomic variations potentially underlying a phenotype, such as hypertension, in an indivi…

Race, Hypertensive Disorders of Pregnancy and Outcomes in Peripartum Cardiomyopathy Open

Vincenzo B. Polsinelli, Agnes Koczo, Amber E. Johnson, Uri Elkayam, Leslie Cooper , et al. · 2023

Introduction Black women with peripartum cardiomyopathy (PPCM) have a high prevalence of hypertensive disorders of pregnancy (HDP) and worse clinical outcomes compared with other races. We examined the role of HDP and race on myocardial re…

Association of activin A and postpartum blood pressure in peripartum cardiomyopathy Open

Agnes Koczo, Amy Marino, Vincenzo B. Polsinelli, Rami Alharethi, Julie B. Damp , et al. · 2023

Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of <i>CDCP1</i> and Cardiac Fibrosis Open

Duan Liu, Min Wang, Vishakantha Murthy, Dennis M. McNamara, Thanh Thanh L. Nguyen , et al. · 2023

BACKGROUND: Dilated cardiomyopathy (DCM) is a major cause of heart failure and carries a high mortality rate. Myocardial recovery in DCM-related heart failure patients is highly variable, with some patients having little or no response to …

Sex Differences in Myocardial Histology, Gene Expression, and Myocardial Recovery in Recent-Onset Cardiomyopathy Open

Agnes Koczo, Anjali Rao, Randall C. Starling, Leslie T. Cooper, G. William Dec , et al. · 2023

Improved waitlist and comparable post-transplant outcomes in simultaneous heart-kidney transplantation under the 2018 heart allocation system Open

Yeahwa Hong, Nicholas R. Hess, Luke A. Ziegler, Gavin Hickey, Jessica Huston , et al. · 2023

Serum proteomic analysis of peripartum cardiomyopathy reveals a unique disease with distinctive dysregulation of inflammatory and cholesterol metabolism pathways Open

Jana Lovell, Kevin Bermea, Sylvie Rousseau, Charles D. Cohen, Aashik Bhalodia , et al. · 2023

Background The pathophysiology of peripartum cardiomyopathy (PPCM) and its defining features when compared to other forms of cardiomyopathy remain unclear, thus limiting the development of targeted therapies. Methods To address this knowle…

Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4‐Human Leukocyte Antigen‐DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension Open

Neha Hafeez, Anna Kirillova, Yunshan Yue, Rashmi J. Rao, Neil J. Kelly , et al. · 2023

Background Pulmonary arterial hypertension (PAH) is a complex, fatal disease where disease severity has been associated with the single nucleotide polymorphism (SNP) rs2856830, located near the human leukocyte antigen DPA1 (HLA‐DPA1) gene.…

Clinical trends, risk factors, and temporal effects of post-transplant dialysis on outcomes following orthotopic heart transplantation in the 2018 United States heart allocation system Open

Yeahwa Hong, Nicholas R. Hess, Luke A. Ziegler, Gavin Hickey, Jessica H. Huston , et al. · 2023

Sex and age differences in sST2 in cardiovascular disease Open

Danielle J. Beetler, Katelyn A. Bruno, Damian N. Di Florio, Erika J. Douglass, S Shrestha , et al. · 2023

Aims The goal of this study was to determine whether sex and age differences exist for soluble ST2 (sST2) for several cardiovascular diseases (CVDs). Methods We examined sST2 levels using an ELISA kit for myocarditis ( n = 303), cardiomyop…

NAV3 is a genetic determinant of myocardial recovery in dilated cardiomyopathy and attenuates cardiac fibrosis Open

M Wang, D Liu, T. T. Nguyen, Dennis M. McNamara, Simona Barlera , et al. · 2022

Background A genome-wide association study (GWAS) assessing change in left ventricular ejection fraction (LVEF) in dilated cardiomyopathy (DCM), a surrogate marker of morbidity and mortality in heart failure (HF), had not been performed pr…

Loss of cardiomyocyte CYB5R3 impairs redox equilibrium and causes sudden cardiac death Open

Nolan T. Carew, Heidi M. Schmidt, Shuai Yuan, Joseph C. Galley, Robert M. Hall , et al. · 2022

Sudden cardiac death (SCD) in patients with heart failure (HF) is allied with an imbalance in reduction and oxidation (redox) signaling in cardiomyocytes; however, the basic pathways and mechanisms governing redox homeostasis in cardiomyoc…

An individualized Bayesian method for estimating genomic variants of hypertension Open

Md Asad Rahman, Chunhui Cai, Dennis M. McNamara, Ying Ding, Gregory F. Cooper , et al. · 2022

Background Genomic variants of disease are often discovered nowadays through population-based genome-wide association studies (GWAS). Identifying genomic variations potentially underlying a phenotype, such as hypertension, in an individual…

Left Ventricular Assist Device Outflow Graft Obstruction Caused by Extrinsic Compression Open

Z. Tushak, B.C. Morelli, Tim Montrief, A. Davila, K. Bahl , et al. · 2022

Developing and Implementing an mHealth Heart Failure Self-care Program to Reduce Readmissions: Randomized Controlled Trial Open

Amber E. Johnson, Shuvodra Routh, Christy Taylor, Meagan Leopold, Kathryn Beatty , et al. · 2022

Background Patients admitted with decompensated heart failure (HF) are at risk for hospital readmission and poor quality of life during the discharge period. Lifestyle behavior modifications that promote the self-management of chronic card…

Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease Open

Polakit Teekakirikul, Wenjuan Zhu, George C. Gabriel, Cullen B. Young, Kylia Williams , et al. · 2021

Heart Failure Association of the ESC, Heart Failure Society of America and Japanese Heart Failure Society Position statement on endomyocardial biopsy Open

Petar Seferović, Hiroyuki Tsutsui, Dennis M. McNamara, Arsen Ristić, Cristina Basso , et al. · 2021

Endomyocardial biopsy (EMB) is an invasive procedure, globally most often used for the monitoring of heart transplant (HTx) rejection. In addition, EMB can have an important complementary role to the clinical assessment in establishing the…

Genetic and Phenotypic Landscape of Peripartum Cardiomyopathy Open

Rahul Goli, Jian Li, Jeff Brandimarto, Lisa D. Levine, Valerie Riis , et al. · 2021

Background: Peripartum cardiomyopathy (PPCM) occurs in ≈1:2000 deliveries in the United States and worldwide. The genetic underpinnings of PPCM remain poorly defined. Approximately 10% of women with PPCM harbor truncating variants in TTN (…

SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function Open

Wei Sun, Ying Tang, Yi‐Yin Tai, Adam Handen, Jingsi Zhao , et al. · 2020

Heart Transplantation Open

Eileen Hsich, Eugene H. Blackstone, Lucy Thuita, Dennis M. McNamara, Joseph G. Rogers , et al. · 2020

20-Year Survival Following Orthotopic Heart Transplantation in the United States Open

Nicholas R. Hess, Laura Seese, Michael Mathier, Mary Keebler, Gavin Hickey , et al. · 2020

Background: This study evaluated 20-year survival following adult orthotopic heart transplantation (OHT). Methods: The United Network of Organ Sharing Registry database was queried to study adult OHT recipients between 1987-1998 with over …

Nationwide Variability in the Use of Induction Immunosuppression for Adult Heart Transplantation Open

Carlos E. Díaz-Castrillón, Laura Seese, Michael Mathier, Mary Keebler, Gavin Hickey , et al. · 2020

Background: Institutional factors have been shown to impact outcomes following orthotopic heart transplantation (OHT). This study evaluated center variability in the utilization of induction therapy for OHT and its implications on clinical…

Impact of Socioeconomic Factors on Patient Desire for Early LVAD Therapy Prior to Inotrope Dependence Open

Inna Tchoukina, Keyur B. Shah, Jennifer T. Thibodeau, Jerry D. Estep, Anuradha Lala , et al. · 2019

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