Explanipedia

Genome-wide association study of lung function decline using elastic-net regression: a prospective analysis in Korean cohort Open

Eunhye Bae, Sohee Oh, Jung‐Kyu Lee, Deog Kyeom Kim · 2025

Our study identified novel SNPs associated with FEV₁ decline and developed a GRS that could help predict individuals at higher risk of rapid FEV₁ decline. The influence of genetic factors on the annual rate of decline…

Efficacy and safety of HL-301 compared with erdosteine in acute bronchitis: a randomized, double-blind, non-inferiority trial Open

Ji-Yong Moon, Joon Young Choi, Youlim Kim, Hye Jung Park, Yong Bum Park , et al. · 2025

Background/Aims: This study evaluated the non-inferiority of HL-301 to erdosteine in terms of symptom relief and the anti- inflammatory effects in acute bronchitis patients not treated with antibiotics.Methods: In a double-blind, non-infer…

Smartphone App–Guided Pulmonary Rehabilitation in Chronic Respiratory Diseases: Randomized Controlled Trial Open

Chiwook Chung, Deog Kyeom Kim, Jung‐Kyu Lee, Eun Young Heo, Hee Kwon , et al. · 2025

Background Pulmonary rehabilitation improves exercise capacity, dyspnea, quality of life, and survival in patients with chronic respiratory disease. However, center-based pulmonary rehabilitation programs remain unavailable in many health …

Mucus plug and lung cancer incidence in patients with COPD Open

Soo‐Chan Kim, Heemoon Park, Hyo Jin Lee, Jung‐Kyu Lee, Eun Young Heo , et al. · 2025

Airway mucus plugs are frequently observed on chest computed tomography (CT) scans in patients with chronic obstructive pulmonary disease (COPD). However, the association between the presence of mucus plugs and the risk of lung cancer in C…

A Decade of Healthcare Quality Assessment for Chronic Obstructive Pulmonary Disease in South Korea: Trends and Implications (2014–2023) Open

Hyeon‐Kyoung Koo, Chin Kook Rhee, Kyung Hoon Min, Ji‐Yong Moon, Yong Il Hwang , et al. · 2025

Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder associated with substantial morbidity and healthcare costs. Effective outpatient management can prevent exacerbations and reduce hospitalization rates. Sinc…

Response to Daungsupawong et al. Open

Sang Hyuk Kim, Hyun Lee, Min Ji Kim, Min Gu Kang, Jong Seung Kim , et al. · 2025

Unbalanced Associations between Physical, Psychological, and Social Domains of the Leicester Cough Questionnaire: Network and Mediation Analyses Open

Jieun Kang, Jiyeon Kang, Sung Jun Chung, Hyung Koo Kang, Sung-Soon Lee , et al. · 2025

Background: The Leicester Cough Questionnaire (LCQ) is a validated instrument for evaluating cough-related impairments within three domains: physical, psychological, and social. This study investigated how the physical, psychological, and …

Deep Learning–Based Chronic Obstructive Pulmonary Disease Exacerbation Prediction Using Flow-Volume and Volume-Time Curve Imaging: Retrospective Cohort Study Open

Eun‐Tae Jeon, Heemoon Park, Jung‐Kyu Lee, Eun Young Heo, Chang‐Hoon Lee , et al. · 2025

Background Chronic obstructive pulmonary disease (COPD) is a common and progressive respiratory condition characterized by persistent airflow limitation and symptoms such as dyspnea, cough, and sputum production. Acute exacerbations (AE) o…

Maximal Forced Inspiratory Flow Dynamics and Acute Exacerbation in Chronic Obstructive Pulmonary Disease Patients with Exacerbation History Open

Heemoon Park, Jung‐Kyu Lee, Eun Young Heo, Deog Kyeom Kim, Hyun Woo Lee · 2025

Background: Chronic obstructive pulmonary disease (COPD), characterized by progressive airflow obstruction and frequent exacerbations, is a significant global health burden. COPD severity has traditionally been assessed using expiratory fl…

Distinct risks of exacerbation and lung function decline between never-smokers and ever-smokers with COPD Open

Heemoon Park, Soo Min Jo, Kwang Nam Jin, Hyo Jin Lee, Hyun Woo Lee , et al. · 2025

Background Chronic obstructive pulmonary disease (COPD) can occur in patients without a history of smoking, which is a strong risk factor for COPD. However, few studies have focused on the prognosis of never-smokers with COPD. We investiga…

Effects of Vaccination on Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Nationwide Population-Based Cohort Study Open

Sang Hyuk Kim, Hyun Lee, Min Ji Kim, Min Gu Kang, Jong Seung Kim , et al. · 2025

Background: Coronavirus disease 2019 (COVID-19) vaccination may offer benefits for patients with chronic obstructive pulmonary disease (COPD). However, the evidence on whether the vaccination decreases the frequency of acute exacerbation o…

Effects of Triple Therapy on the Clinical Course of Non-Eosinophilic COPD Groups B Open

Jin Hwa Song, Shinhee Park, Jong Geol Jang, Youlim Kim, Chin Kook Rhee , et al. · 2025

In conclusion, our research suggests that triple therapy was associated with a higher risk of moderate-to-severe exacerbations in non-eosinophilic COPD categorized as GOLD B compared with dual therapy.

Risk Factors of FEV<sub>1</sub>/FVC Decline in COPD Patients Open

Na Young Kim, Deog Kyeom Kim, Shinhee Park, Young‐il Hwang, Hyewon Seo , et al. · 2024

We identified the risk factors for rapid FEV₁/FVC decline, including BMI, smoking, symptoms deterioration, FEV₁ decline, and adherence to standard inhaler treatment. Our findings underscore the potential benefits of maintaining consistent …

Diagnosis and evaluation of small airway disease and COPD using impulse oscillometry Open

Heemoon Park, Hyo Jin Lee, Hyun Woo Lee, Tae Yun Park, Eun Young Heo , et al. · 2024

Impulse oscillometry (IOS) is a sensitive tool for assessing small airway function in patients with chronic obstructive pulmonary disease (COPD). This study aimed to differentiate between COPD, small airway disease (SAD), and normal groups…

Similarity analyses of causative viruses for chronic obstructive pulmonary disease and asthma exacerbations Open

Tai Joon An, J.H. Lee, Myoungin Shin, Kwang Ha Yoo, Yong Il Hwang , et al. · 2024

This was the first study to report the synchronicity between a retrospective multicenter cohort study of viruses that can cause COPD or asthma exacerbations and nationwide surveillance system data.

The effect of nebulized N-acetylcysteine on the phlegm of chronic obstructive pulmonary disease: the NEWEST study Open

Chin Kook Rhee, Seong Yong Lim, Won‐Yeon Lee, Ji Ye Jung, Yong Bum Park , et al. · 2024

Background Phlegm is prevalent symptom in patients with chronic obstructive pulmonary disease (COPD). Few studies have investigated the effectiveness of N-acetylcysteine (NAC) nebulizer therapy in COPD patients. We evaluated the effect of …

Risk factors of acute exacerbation and disease progression in young patients with COPD Open

Juye Bae, Hyo Jin Lee, Kwang Yong Choi, Jung‐Kyu Lee, Tae Yun Park , et al. · 2024

Objective We aimed to elucidate the clinical factors associated with acute exacerbation and disease progression in young patients with chronic obstructive pulmonary disease (COPD). Methods This retrospective longitudinal observational stud…

Efficacy and safety of mixture of ivy leaf extract and coptidis rhizome in the treatment of acute bronchitis: multicenter, randomized, double-blinded, active-controlled, parallel, therapeutic confirmatory clinical trial Open

Kate Han, Tae‐Hyung Kim, Seung Won, Hyoung Kyu Yoon, Deog Kyeom Kim , et al. · 2024

Mixture of Ivy Leaf Extract and Coptidis rhizome syrup is as effective and safe as P. sidoides in controlling symptoms of acute bronchitis.

Eosinophilia Is a Favorable Marker for Pneumonia in Chronic Obstructive Pulmonary Disease Open

Kang-Mo Gu, Jae‐Woo Jung, Min‐Jong Kang, Deog Kyeom Kim, Hayoung Choi , et al. · 2024

Background: Patients with chronic obstructive pulmonary disease (COPD) expressing eosinophilia experience slightly fewer episodes of community-acquired pneumonia (CAP), than those without eosinophilia. However, the severity and burden of h…

Response Open

Joon Young Choi, Ki Uk Kim, Deog Kyeom Kim, Yu‐Il Kim, Tae‐Hyung Kim , et al. · 2024

Differential decline of lung function in COPD patients according to structural abnormality in chest CT Open

Hyun Woo Lee, Jung‐Kyu Lee, Youlim Kim, An‐Soo Jang, Yong Il Hwang , et al. · 2024

Diffusing capacity as an independent predictor of acute exacerbations in chronic obstructive pulmonary disease Open

Heemoon Park, Hyo Jin Lee, Jung‐Kyu Lee, Tae Yun Park, Kwang Nam Jin , et al. · 2024

Differential response to roflumilast in patients with chronic obstructive pulmonary disease: real-world evidence Open

Hyun Woo Lee, Jiyu Sun, Hyo Jin Lee, Jung‐Kyu Lee, Tae Yeon Park , et al. · 2024

The benefit of roflumilast in moderate-to-severe exacerbations was estimated to be greater in specific subgroups of patients with COPD. Personalised approaches to roflumilast based on clinical phenotypes would be effective for COPD.

Acute Exacerbation and Longitudinal Lung Function Change of Preserved Ratio Impaired Spirometry Open

Si Mong Yoon, Kwang Nam Jin, Hyo Jin Lee, Hyun Woo Lee, Tae Yun Park , et al. · 2024

PRISm patients had no significant difference in the risk of acute exacerbations, but a significantly slower decline of lung function during longitudinal follow-up, compared with COPD patients.

Clinical outcomes of long-term inhaled combination therapies in patients with bronchiectasis and airflow obstruction Open

Hyo Jin Lee, Jung‐Kyu Lee, Tae Yeon Park, Eun Young Heo, Deog Kyeom Kim , et al. · 2024

Association between timed up-and-go test and subsequent pneumonia: A cohort study Open

Hyo Jin Lee, Sohee Oh, Hyun Woo Lee, Jung‐Kyu Lee, Eun Young Heo , et al. · 2024

Background Sarcopenia is a risk factor for pneumonia in the elderly, and the timed up-and-go test (TUG) can be used as a screening tool for sarcopenia in this population. This study aimed to evaluate the association between TUG test result…

Sex Differences in Chronic Cough Epidemiology: The Korean Cough Study Group Open

Jiyeon Kang, Woo Jung Seo, Jieun Kang, Jung Gon Kim, Sung Jun Chung , et al. · 2024

The sex disparities in prevalence and severity of cough varied significantly depending on the age category and etiology. Understanding the specific sex-based difference could enhance comprehension of cough-related pathophysiology and treat…

Sex-related disparities in cough-associated symptoms across different age groups Open

Jiyeon Kang, Woo Jung Seo, Jung Gon Kim, Ji-Yong Moon, Deog Kyeom Kim , et al. · 2024

Background: Sex-related disparities in the prevalence of chronic cough have been consistently reported globally, with varying male-to-female ratios. Objectives: This study aimed to evaluate sex-related differences by comparing correlations…

A Genome-Wide Association Study for FEV1 Decline Via Elastic-Net Regression in General Population Open

Eunhye Bae, Sohee Oh, Jung-Kyu Lee, Eun Young Heo, Deog Kyeom Kim , et al. · 2024

Spirometric Interpretation and Clinical Relevance According to Different Reference Equations Open

Hyun Woo Lee, Jung‐Kyu Lee, Yong-Il Hwang, Hyewon Seo, June Hong Ahn , et al. · 2023

GLI-2012 reference equation may not accurately reflect FEV₁ (%) in the Korean population, but the Z-score using GLI-2012 equation can be a viable option for assessing FEV₁ and airflow limitation in COPD patients. Simi…

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