Explanipedia

Interactive effects of Bisphenol F exposure and TLR4 rs4986790 on unexplained miscarriage Open

Manli Wang, Wenxin Huang, Weina Chen, Xiaofeng Yue, Yu Sun , et al. · 2025

Late-stage functionalization of anticancer agent Daniquidone and the in vitro anticancer activities of the derivatives Open

Geshuyi Chen, Yiying Zeng, Xin Chen, Zhe Chang, Pei Yuan , et al. · 2025

Nitrogen heterocycles play an important role in drugs and natural products. C-H late-stage functionalization (LSF) of N-heterocycles might provide a direct route to construct diversified analogues with potential pharmaceutical activities. …

Study of the ReS2-CoO/CoS2 Heterostructure for Efficient Bifunctional Electrocatalysis Open

Depeng Zhao, Zhikun Peng, Qingqing Pang, Qiaoyun Liu, Zhongyi Liu · 2025

Enhancing Water/Seawater Electrolysis Catalysis Through Ag Doping: High-Performance and Stable Nicr-Ldh for Multifunctional Electrocatalyst Open

Hongyuan Ren, Rongda Zhao, Kai Jia, Huiya Zhou, Depeng Zhao , et al. · 2025

Triflic Anhydride‐Mediated Friedel–Crafts Arylation of Quinazolin‐4(3H)‐ones Open

Zhenying Yao, Zhanyong Tang, Depeng Zhao · 2024

Since the initial report, the Friedel–Crafts reaction has become a powerful tool to functionalize arenes. Nevertheless, the use of nitrogen heterocycles as electrophiles in Friedel‐Crafts reactions has been less explored. Here, we show a F…

BaP/BPDE suppresses homologous recombination repair in human trophoblast cells to induce miscarriage: The roles of lnc-HZ08 Open

Weina Chen, Chenglong Ma, Manli Wang, Xinying Huang, Xueyu Chen , et al. · 2024

Benzo(a)pyrene (BaP) or benzo (a) pyrene 7,8-dihydrodiol-9,10-epoxide (BPDE) exposure causes trophoblast cell dysfunctions and induces miscarriage, which is generally epigenetically regulated. Homologous recombination (HR) repair of DNA do…

Conformational studies of biaryl-bridged seven-membered lactones with a quaternary carbon center Open

Yu Zhang, Yueyang Yu, Xiaoqiang Ma, Xiaofei Zhao, Jialin Huang , et al. · 2024

Here, conformations of a series of 7,7-disubstituted-dibenzo[ b , d ]oxepin-6(7 H )-ones were studied and we found that the stable conformers all favor to place the larger group in the axial position instead of the equatorial position.

Interface Engineering Accelerated Surface Reconstruction for Electrocatalytic Water Splitting and Energy Storage Device Through Hybrid Structured Znco2o4@Nico-Ldh Nanocomposite Open

Ruiyu Li, Songlin Xu, Jun Xiang, Ziqing Ai, Jingang Qi , et al. · 2024

Enhancing Water/Seawater Electrolysis Catalysis Through Ag Doping: High-Performance and Stable Nicr-Ldh for Multifunctional Electrocatalyst Open

Hongyuan Ren, Rongda Zhao, Songlin Xu, Kai Jia, Huiya Zhou , et al. · 2024

Visible light-induced Mallory reaction of tertiary benzanilides via iminium intermediates Open

Xiaoqiang Ma, Si Wang, Zhanyong Tang, Jialin Huang, Tianhao Jia , et al. · 2024

We report the first Mallory reaction of tertiary benzanilides promoted by visible-light via iminium intermediates formed in situ from tertiary benzanilide, Tf 2 O and pyridine. A wide range of substrates are compatible with this method.

Copper catalyzed Shono-type oxidation of proline residues in peptide Open

Zhe Chang, Si Wang, Jialin Huang, Geshuyi Chen, Zhanyong Tang , et al. · 2023

Since the initial report in 1975, the Shono oxidation has become a powerful tool to functionalize the α position of amines, including proline derivatives, by electrochemical oxidation. However, the application of electrochemical Shono oxid…

Retraction Note: Intrinsically unidirectional chemically fuelled rotary molecular motors Open

Ke Mo, Yu Zhang, Zheng Dong, Yuhang Yang, Xiaoqiang Ma , et al. · 2023

Ssc-mir-221-3p regulates melanin production in Xiang pigs melanocytes by targeting the TYRP1 gene Open

Wei Yuan, Hai Qin, Huan Bi, Depeng Zhao, Yiyu Zhang , et al. · 2023

Background MicroRNAs (miRNAs) are small endogenous non-coding RNAs that regulate gene expression by down-regulating it. Several studies have suggested that miRNAs plays a crucial role in mammalian skin color production. The TYRP1 gene, a m…

Ssc-miR-221-3p regulates melanin production in Xiang pigs melanocytes by targeting the TYRP1 gene Open

Wei Yuan, Hai Qin, Huan Bi, Depeng Zhao, Yiyu Zhang , et al. · 2023

Background MicroRNAs (miRNAs) are small non-coding RNAs of endogenous origin that down-regulate gene expression. An increasing number of studies have confirmed that miRNAs play an important role in mammalian hair color production, and the …

Late-stage functionalization of 5-nitrofurans derivatives and their antibacterial activities Open

Geshuyi Chen, Zhe Chang, Pei Yuan, Si Wang, Yongxiu Yang , et al. · 2023

Cu-catalyzed C–H late-stage functionalization were employed to modify 5-nitrofuran drugs. Compound 1 and 18 were the most active among all compounds, and the cell cytotoxicity assays were conducted.

Ssc-miR-221-3p regulates melanin production in Xiang pigs melanocytes by targeting the TYRP1 gene Open

Wei Yuan, Hai Qin, Huan Bi, Depeng Zhao, Yiyu Zhang , et al. · 2022

Background: MicroRNAs (miRNAs) are small non-coding RNAs of endogenous origin that down-regulate gene expression. An increasing number of studies have confirmed that miRNAs play an important role in mammalian hair color production, and the…

CCDC 2170189: Experimental Crystal Structure Determination Open

Ke Mo, Yu Zhang, Dong Zheng, Yuhang Yang, Xiaoqiang Ma , et al. · 2022

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

RETRACTED ARTICLE: Intrinsically unidirectional chemically fuelled rotary molecular motors Open

Ke Mo, Yu Zhang, Zheng Dong, Yuhang Yang, Xiaoqiang Ma , et al. · 2022

The novel indomethacin derivative CZ-212-3 exerts antitumor effects on castration-resistant prostate cancer by degrading androgen receptor and its variants Open

Hong Wang, Zhe Chang, Guodi Cai, Ping Yang, Jianghe Chen , et al. · 2021

Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles Open

Zhe Chang, Jialin Huang, Si Wang, Geshuyi Chen, Heng Zhao , et al. · 2021

Nitrogen heterocycle represents a ubiquitous skeleton in natural products and drugs. Late-stage C(sp 3 )-H bond functionalization of N-heterocycles with broad substrate scope remains a challenge and of particular significance to modern che…

The Role of Elastase in Corneal Epithelial Barrier Dysfunction Caused by Pseudomonas aeruginosa Exoproteins Open

Ye Li, Yingwei Wang, Chunwei Li, Depeng Zhao, Qinyuan Hu , et al. · 2021

Elastase plays a critical role in corneal epithelial barrier dysfunction caused by Pseudomonas aeruginosa exoproteins via damaging tight junctions. The inhibition of elastase could protect the corneal epithelial barrier via reducing virule…

Realizing high performance flexible supercapacitors by electrode modification Open

Tong Xia, Depeng Zhao, Qing Xia, Ahmad Umar, Xiang Wu · 2021

We prepare hybrid structured NiCo 2 S 4 @PPy nanoarchitectures by a hydrothermal method and subsequent electrodeposition process. The assembled asymmetric device presents an energy density of 59.59 W h kg −1 at 1404.04 W kg −1 .

NiCo Layered Double Hydroxide Nanosheets with Enhanced Electrochemical Performance Open

Mengdi Wang, Xingyu Liu, Hengqi Liu, Depeng Zhao, Xiang Wu · 2021

NiMoCo layered double hydroxides for electrocatalyst and supercapacitor electrode Open

Hengqi Liu, Depeng Zhao, Ying Liu, Yongli Tong, Xiang Wu , et al. · 2020

A Chemically Driven Rotary Molecular Motor Based on Reversible Lactone Formation with Perfect Unidirectionality Open

Yu Zhang, Zhe Chang, Heng Zhao, Stefano Crespi, Ben L. Feringa , et al. · 2020

Synthesis of Functionalized Indoles via Palladium-Catalyzed Cyclization of N-(2-allylphenyl) Benzamide: A Method for Synthesis of Indomethacin Precursor Open

Zhe Chang, Tong Ma, Yu Zhang, Zheng Dong, Heng Zhao , et al. · 2020

We developed an efficient method for synthesis of substituted N-benzoylindole via Pd(II)-catalyzed C–H functionalization of substituted N-(2-allylphenyl)benzamide. The reaction showed a broad substrate scope (including N-acetyl and N-Ts su…

Effects of nitric oxide donor N,N’-di-sec-butyl-N,N’-dinitroso-1,4-phenylenediamine on the expression of interferon-gamma in tumor infiltrating lymphocytes Open

Jing Fan, Xuemei Li, Zhen Gao, Depeng Zhao, Ping Wang , et al. · 2019

Nitric oxide (NO) has been proven to be a key regulator in the mammalian immune response, such as the innate and adaptive immune responses to tumors. The messenger NO involves T helper cell differentiation and lymphocyte biofunctions. In t…

Solvent Mixing To Induce Molecular Motor Aggregation into Bowl-Shaped Particles: Underlying Mechanism, Particle Nature, and Application To Control Motor Behavior Open

Linda E. Franken, Yuchen Wei, Jiawen Chen, Egbert J. Boekema, Depeng Zhao , et al. · 2018

Control over dynamic functions in larger assemblies is key to many molecular systems, ranging from responsive materials to molecular machines. Here we report a molecular motor that forms bowl-shaped particles in water and how confinement o…

A-type CpG ODN with higher binding affinity to LvToll1 could probably activate downstream IFN system-like antiviral response in shrimp Litopenaeus vannamei Open

Jiachao Xu, Depeng Zhao, Mingzhe Sun, L Wang, Zhihao Jia , et al. · 2018

CpG oligodeoxynucleotides (CpG ODNs) is a widely used immune adjuvant, which could activate various immune responses including antiviral response through interaction with Toll-like receptor 9 (TLR9) in mammals. In the present study, four t…

The immunosuppressive effects of continuous CpG ODNs stimulation in chinese mitten crab, Eriocheir sinensis Open

Depeng Zhao, L Song, Renzhi Liu, Zhongxiu Liang, L Wang , et al. · 2018

CpG oligodeoxynucleotides (CpG ODNs) have been widely used as a novel vaccine adjuvant in mammals due to its immune protection, long effectiveness and safety. In the present study, the long-term immune effects as well as immunosuppression …

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