Der Jiun Ooi
YOU?
Author Swipe
View article: From Lab to Clinic: Success Stories of Repurposed Drugs in Treating Major Diseases
From Lab to Clinic: Success Stories of Repurposed Drugs in Treating Major Diseases Open
Drug repurposing, the process of identifying new therapeutic uses for existing drugs, has emerged as a cost‐effective and time‐saving alternative to traditional drug development. This strategy leverages the known pharmacological and safety…
View article: A concise guide to essential R packages for analyses of DNA, RNA, and proteins
A concise guide to essential R packages for analyses of DNA, RNA, and proteins Open
R is widely regarded as unrivaled by other high-level programming languages for its statistical functions. The popularity of R as a statistical language has led many to overlook its applications outside the statistical realm. In this brief…
View article: In Vitro Investigation of Antioxidant and Antidiabetic Properties of Phenolic-Rich Extract from Stingless Bee Honey (Heterotrigona itama)
In Vitro Investigation of Antioxidant and Antidiabetic Properties of Phenolic-Rich Extract from Stingless Bee Honey (Heterotrigona itama) Open
Introduction: The increase of Type 2 diabetes mellitus has prompted numerous research toward finding an alternative to manage the disease through the oxidant-antioxidant balance, mainly through bioactive compounds in natural products. This…
View article: The effect of oil pulling in comparison with chlorhexidine and other mouthwash interventions in promoting oral health: A systematic review and <scp>meta‐analysis</scp>
The effect of oil pulling in comparison with chlorhexidine and other mouthwash interventions in promoting oral health: A systematic review and <span>meta‐analysis</span> Open
Objectives A meta‐analytic review was performed to critically synthesize the evidence of oil pulling on improving the parameters of gingival health, plaque control and bacteria counts against chlorhexidine and other mouthwash or oral hygie…
View article: Challenges and Strategies for Improving Access to Cancer Drugs in Malaysia: Summary of Opinions Expressed at the 2nd MACR International Scientific Conference 2022
Challenges and Strategies for Improving Access to Cancer Drugs in Malaysia: Summary of Opinions Expressed at the 2nd MACR International Scientific Conference 2022 Open
Considerable progress has been made in cancer drug development in recent decades. However, for people in low- and middle-income countries, including Malaysia, many of these drugs are not readily available. During the 2nd Malaysian Associat…
View article: Germinated brown rice extract reduces brain lipid peroxidation and Aβ levels via regulations of BACE1, RAGE, IDE and LRP1 expressions in high fat/cholesterol diet-fed rats
Germinated brown rice extract reduces brain lipid peroxidation and Aβ levels via regulations of BACE1, RAGE, IDE and LRP1 expressions in high fat/cholesterol diet-fed rats Open
A strong association presents between excessive amyloid-β (Aβ) buildup and oxidative stress with Alzheimer’s disease (AD). In view of the multifaceted neuroprotective effects of some dietary elements, the beneficial effect of germinated br…
View article: A summary of the second MACR international scientific conference (2nd MSC)
A summary of the second MACR international scientific conference (2nd MSC) Open
View article: The Ecopsychological, Spiritual, Physiological Health and Mood Benefits of Zikr Meditation and Nature for Muslim University Students
The Ecopsychological, Spiritual, Physiological Health and Mood Benefits of Zikr Meditation and Nature for Muslim University Students Open
Muslim students' wellbeing is said to be impacted by zikr meditation because it fosters a sense of connection between the self and nature. Consequently, this study attempts to look into how zikr meditation and being in nature might help Mu…
View article: Modulation of High-Fat Diet-Induced Brain Oxidative Stress by Ferulate-Rich Germinated Brown Rice Ethyl Acetate Extract
Modulation of High-Fat Diet-Induced Brain Oxidative Stress by Ferulate-Rich Germinated Brown Rice Ethyl Acetate Extract Open
The oxidative stress resulting from the production of reactive oxygen species plays a vital role in inflammatory processes and is associated with neurodegenerative changes. In view of the ability of germinated brown rice (GBR) to improve l…
View article: Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review
Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review Open
Colorectal cancer (CRC) is the second most deadly cancer worldwide. CRC management is challenging due to late detection, high recurrence rate, and multi-drug resistance. Herbs and spices used in cooking, practised for generations, have bee…
View article: Theragnostic Applications of Mammal and Plant-Derived Extracellular Vesicles: Latest Findings, Current Technologies, and Prospects
Theragnostic Applications of Mammal and Plant-Derived Extracellular Vesicles: Latest Findings, Current Technologies, and Prospects Open
The way cells communicate is not fully understood. However, it is well-known that extracellular vesicles (EVs) are involved. Researchers initially thought that EVs were used by cells to remove cellular waste. It is now clear that EVs funct…
View article: Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies
Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies Open
Colorectal cancer (CRC) is the second most deadly cancer. Global incidence and mortality are likely to be increased in the coming decades. Although the deaths associated with CRC are very high in high-income countries, the incidence and fa…
View article: Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Ameliorated Insulin Resistance in Type 2 Diabetes Mellitus Rats
Human Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Ameliorated Insulin Resistance in Type 2 Diabetes Mellitus Rats Open
Human umbilical cord mesenchymal stem cell-derived small extracellular vesicle (hUC-MSCs-sEVs) therapy has shown promising results to treat diabetes mellitus in preclinical studies. However, the dosage of MSCs-sEVs in animal studies, up to…
View article: Lifestyle and preventive medical epigenetics
Lifestyle and preventive medical epigenetics Open
Healthy living depends on a balanced interaction between lifestyle factors and the epigenome. Converging evidence suggests that lifestyle events such as diet, physical activity, and environment influence the development of a healthy phenot…
View article: Contributors
Contributors Open
View article: Correlation of Mortality Burdens of Cerebrovascular Disease and Diabetes Mellitus with Domestic Consumption of Soya and Palm Oils
Correlation of Mortality Burdens of Cerebrovascular Disease and Diabetes Mellitus with Domestic Consumption of Soya and Palm Oils Open
Background: Cerebrovascular diseases (CBVDs) and diabetes mellitus (DM) are interrelated and cumbersome global health burdens. However, the relationship between edible oils consumption and mortality burdens of CBVDs and DM has not yet been…
View article: Safety and Neuroprotective Efficacy of Palm Oil and Tocotrienol-Rich Fraction from Palm Oil: A Systematic Review
Safety and Neuroprotective Efficacy of Palm Oil and Tocotrienol-Rich Fraction from Palm Oil: A Systematic Review Open
Background: Several natural products have been reported to elicit beneficial effects against neurodegenerative disorders due to their vitamin E contents. However, the neuroprotective efficacy of palm oil or its tocotrienol-rich fraction (T…
View article: Curculigoside and polyphenol-rich ethyl acetate fraction of Molineria latifolia rhizome improved glucose uptake via potential mTOR/AKT activated GLUT4 translocation
Curculigoside and polyphenol-rich ethyl acetate fraction of Molineria latifolia rhizome improved glucose uptake via potential mTOR/AKT activated GLUT4 translocation Open
Adipose tissue is one of the major organs responsible for rapid restoration of postprandial glucose fluxes. Being the major isoform of glucose transporter in adipose tissue, regulations of insulin-dependent GLUT4 trafficking have always be…
View article: Polyphenol-rich ethyl acetate fraction of Molineria latifolia rhizome restores oxidant-antioxidant balance by possible engagement of KEAP1-NRF2 and PKC/NF-κB signalling pathways
Polyphenol-rich ethyl acetate fraction of Molineria latifolia rhizome restores oxidant-antioxidant balance by possible engagement of KEAP1-NRF2 and PKC/NF-κB signalling pathways Open
View article: Defatted Kenaf (<i>Hibiscus cannabinus</i> L.) Seed Meal and Its Phenolic‐Saponin‐Rich Extract Protect Hypercholesterolemic Rats against Oxidative Stress and Systemic Inflammation via Transcriptional Modulation of Hepatic Antioxidant Genes
Defatted Kenaf (<i>Hibiscus cannabinus</i> L.) Seed Meal and Its Phenolic‐Saponin‐Rich Extract Protect Hypercholesterolemic Rats against Oxidative Stress and Systemic Inflammation via Transcriptional Modulation of Hepatic Antioxidant Genes Open
The present study aimed to investigate the antioxidant and anti‐inflammatory properties of defatted kenaf seed meal (DKSM) and its phenolic‐saponin‐rich extract (PSRE) in hypercholesterolemic rats. Hypercholesterolemia was induced using at…
View article: Tissue-specific regulation of insulin-PI3K/Akt, KEAP1-NRF2 and PKC/NF-κB signaling in high fat diet-fed and nicotinamide/streptozotocin-induced diabetic rats
Tissue-specific regulation of insulin-PI3K/Akt, KEAP1-NRF2 and PKC/NF-κB signaling in high fat diet-fed and nicotinamide/streptozotocin-induced diabetic rats Open
Event Abstract Back to Event Tissue-specific regulation of insulin-PI3K/Akt, KEAP1-NRF2 and PKC/NF-κB signaling in high fat diet-fed and nicotinamide/streptozotocin-induced diabetic rats Der Jiun Ooi1* and Maznah Ismail2 1 Faculty of Denti…
View article: Polyphenol-rich ethyl acetate fraction isolated from Molineria latifolia ameliorates insulin resistance in experimental diabetic rats via IRS1/AKT activation
Polyphenol-rich ethyl acetate fraction isolated from Molineria latifolia ameliorates insulin resistance in experimental diabetic rats via IRS1/AKT activation Open
This study aimed to evaluate the effect of ethyl acetate fraction (EAF) isolated from Molineria latifolia rhizome as dietary interventions for type 2 diabetes mellitus (T2DM) and its underlying molecular mechanisms in vivo. Experimental ra…
View article: In utero exposure to germinated brown rice and its oryzanol-rich extract attenuated high fat diet-induced insulin resistance in F1 generation of rats
In utero exposure to germinated brown rice and its oryzanol-rich extract attenuated high fat diet-induced insulin resistance in F1 generation of rats Open
GBR and OE can be used as functional ingredients for the amelioration of HFD-induced epigeneticallymediated insulin resistance.
View article: ISSN Society News
ISSN Society News Open
View article: In utero Exposure to Germinated Brown Rice and Its GABA Extract Attenuates High-Fat-Diet-Induced Insulin Resistance in Rat Offspring
In utero Exposure to Germinated Brown Rice and Its GABA Extract Attenuates High-Fat-Diet-Induced Insulin Resistance in Rat Offspring Open
Background: Numerous studies have reported on the influence of diet on insulin resistance. Our study provides insight into the effect of germinated brown rice (GBR) and γ-aminobutyric acid (GABA) on early environment-d…
View article: ISSN Membership Application Form
ISSN Membership Application Form Open
View article: Bioprospecting the Curculigoside-Cinnamic Acid-Rich Fraction from Molineria latifolia Rhizome as a Potential Antioxidant Therapeutic Agent
Bioprospecting the Curculigoside-Cinnamic Acid-Rich Fraction from Molineria latifolia Rhizome as a Potential Antioxidant Therapeutic Agent Open
Increasing evidence from both experimental and clinical studies depicts the involvement of oxidative stress in the pathogenesis of various diseases. Specifically, disruption of homeostatic redox balance in accumulated body fat mass leads t…
View article: Perinatal exposure to germinated brown rice and its gamma amino-butyric acid-rich extract prevents high fat diet-induced insulin resistance in first generation rat offspring
Perinatal exposure to germinated brown rice and its gamma amino-butyric acid-rich extract prevents high fat diet-induced insulin resistance in first generation rat offspring Open
These results showed that intrauterine exposure to GBR-influenced metabolic outcomes in offspring of rats with underlying epigenetic changes and transcriptional implications that led to improved glucose homeostasis.
View article: Phenolic Rich Extract from <i>Clinacanthus nutans</i> Attenuates Hyperlipidemia‐Associated Oxidative Stress in Rats
Phenolic Rich Extract from <i>Clinacanthus nutans</i> Attenuates Hyperlipidemia‐Associated Oxidative Stress in Rats Open
Clinacanthus nutans is used as traditional medicine in Asia but there are limited scientific studies to support its use. In this study, the stem and leaf of C. nutans were extracted using solvents of differing polarities, and their antioxi…
View article: Nutrigenomic effects of edible bird&rsquo;s nest on&nbsp;insulin signaling in ovariectomized rats
Nutrigenomic effects of edible bird’s nest on insulin signaling in ovariectomized rats Open
Estrogen deficiency alters quality of life during menopause. Hormone replacement therapy has been used to improve quality of life and prevent complications, but side effects limit its use. In this study, we evaluated the use of edible bird…