Dereje D. Jima
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View article: Studying the molecular mechanisms of tef (Eragrostis tef) antioxidant properties in human THP-1 monocytes
Studying the molecular mechanisms of tef (Eragrostis tef) antioxidant properties in human THP-1 monocytes Open
Brown tef (Eragrostis tef) grain extracts increase cellular glutathione (GSH) in THP-1 monocytes, however, the molecular mechanisms remained unclear. In this study, we found that the tef extracts induced luciferase activity by 19-fold in H…
View article: C/EBPβ deficiency enhances keratinocyte apoptosis after UVB-induced DNA damage via regulation of the type I IFN and TNF responses
C/EBPβ deficiency enhances keratinocyte apoptosis after UVB-induced DNA damage via regulation of the type I IFN and TNF responses Open
The epidermis is routinely subjected to DNA damage induced by ultraviolet B (UVB) solar radiation. In addition to activating canonical DNA damage responses such as cycle cell checkpoints and DNA repair, UVB-induced DNA damage can also acti…
View article: Embryonic Exposure to TPhP Elicits Osteotoxicity via Metabolic Disruption in Oryzias latipes
Embryonic Exposure to TPhP Elicits Osteotoxicity via Metabolic Disruption in Oryzias latipes Open
Triphenyl phosphate (TPhP) is a widely used organophosphate flame retardant and plasticizer, raising concerns over its health impacts. This study examined the effects of embryonic TPhP exposure on axial skeletal development and metabolism …
View article: Developmental PBDE exposure impairs histamine release from mast cells by altering granule maturation and calcium signaling in adult male and female mice
Developmental PBDE exposure impairs histamine release from mast cells by altering granule maturation and calcium signaling in adult male and female mice Open
Polybrominated diphenyl ethers (PBDEs) are synthetic flame retardants once widely used in furniture, electronics, and other consumer products. Although phased out in the early 2000s, their persistence and recycling into new materials have …
View article: Differential methylation patterns in cord blood associated with prenatal exposure to neighborhood crime: an epigenome-wide association study and regional analysis
Differential methylation patterns in cord blood associated with prenatal exposure to neighborhood crime: an epigenome-wide association study and regional analysis Open
Exposure to prenatal social stressors during pregnancy is associated with adverse birth outcomes and has been linked to epigenetic changes in DNA methylation (DNAm); however, less understood is the effect of neighborhood-level stressors li…
View article: Prenatal Smoking Exposures and Epigenome-wide Methylation in Newborn Blood
Prenatal Smoking Exposures and Epigenome-wide Methylation in Newborn Blood Open
Maternal sustained smoking has the largest impact on newborn DNA methylation, suggesting a strong influence of the intrauterine environment. We observed minimal impacts for less studied exposures including SHS, maternal former smoking and …
View article: Developing a feasible fast-track testing method for developmental neurotoxicity studies: alternative model for risk assessment of micro- and nanoplastics
Developing a feasible fast-track testing method for developmental neurotoxicity studies: alternative model for risk assessment of micro- and nanoplastics Open
Micro- and nanoplastics (MNPs) are widespread environmental pollutants that pose significant health risks. They originate from industrial processes, consumer products, and environmental degradation, inducing oxidative stress through cellul…
View article: Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits
Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits Open
Understanding the molecular mechanisms of complex traits is essential for developing targeted interventions. We analyzed liver expression quantitative-trait locus (eQTL) meta-analysis data on 1,183 participants to identify conditionally di…
View article: Profiling the cancer-prone microenvironment in a zebrafish model for MPNST
Profiling the cancer-prone microenvironment in a zebrafish model for MPNST Open
Microenvironmental contributions to soft tissue sarcoma progression are relatively undefined, particularly during sarcoma onset. Use of animal models to reveal these contributions is impeded by difficulties in discriminating between microe…
View article: Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits
Liver eQTL meta-analysis illuminates potential molecular mechanisms of cardiometabolic traits Open
View article: Maternal blood lead concentrations, DNA methylation of MEG3 DMR regulating the DLK1/MEG3 imprinted domain and early growth in a multiethnic cohort
Maternal blood lead concentrations, DNA methylation of MEG3 DMR regulating the DLK1/MEG3 imprinted domain and early growth in a multiethnic cohort Open
Prenatal exposure to lead (Pb) is known to decrease fetal growth; but its effects on postnatal growth and mechanistic insights linking Pb to growth are not clearly defined. Genomically imprinted genes are powerful regulators of growth and …
View article: Creation and validation of the first infinium DNA methylation array for the human imprintome
Creation and validation of the first infinium DNA methylation array for the human imprintome Open
Background Differentially methylated imprint control regions (ICRs) regulate the monoallelic expression of imprinted genes. Their epigenetic dysregulation by environmental exposures throughout life results in the formation of common chroni…
View article: Mutant Nrf2E79Q enhances the promotion and progression of a subset of oncogenic Ras keratinocytes and skin tumors
Mutant Nrf2E79Q enhances the promotion and progression of a subset of oncogenic Ras keratinocytes and skin tumors Open
Squamous cell carcinomas (SCCs), including lung, head & neck, bladder, and skin SCCs often display constitutive activation of the KEAP1-NRF2 pathway. Constitutive activation is achieved through multiple mechanisms, including activating mut…
View article: DNA methylation of imprint control regions associated with Alzheimer’s disease in non-Hispanic Blacks and non-Hispanic Whites
DNA methylation of imprint control regions associated with Alzheimer’s disease in non-Hispanic Blacks and non-Hispanic Whites Open
View article: Developmental regulation of cellular metabolism is required for intestinal elongation and rotation
Developmental regulation of cellular metabolism is required for intestinal elongation and rotation Open
Malrotation of the intestine is a prevalent birth anomaly, the etiology of which remains poorly understood. Here, we show that late-stage exposure of Xenopus embryos to atrazine, a widely used herbicide that targets electron transport chai…
View article: Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome
Creation and Validation of the First Infinium DNA Methylation Array for the Human Imprintome Open
Background Differentially methylated imprint control regions (ICRs) regulate the monoallelic expression of imprinted genes. Their epigenetic dysregulation by environmental exposures throughout life results in the formation of common chroni…
View article: Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence
Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence Open
View article: DNA methylation of candidate imprint control regions associated with Alzheimer’s disease in Non‐Hispanic Blacks and Non‐Hispanic Whites
DNA methylation of candidate imprint control regions associated with Alzheimer’s disease in Non‐Hispanic Blacks and Non‐Hispanic Whites Open
Background There are more than 55 million people with dementia worldwide, and it is estimated that currently 6.5 million people are living with Alzheimer’s disease (AD) in the United States. AD exhibits racial disparities whereby the preva…
View article: An epigenome-wide association study of child appetitive traits and DNA methylation
An epigenome-wide association study of child appetitive traits and DNA methylation Open
The etiology of childhood appetitive traits is poorly understood. Early-life epigenetic processes may be involved in the developmental programming of appetite regulation in childhood. One such process is DNA methylation (DNAm), whereby a m…
View article: AHRR Hypomethylation mediates the association between maternal smoking and metabolic profiles in children
AHRR Hypomethylation mediates the association between maternal smoking and metabolic profiles in children Open
Background: Tobacco smoking during pregnancy is associated with metabolic dysfunction in children, but mechanistic insights remain limited. Hypomethylation of cg05575921 in the aryl hydrocarbon receptor repressor ( AHRR ) gene is associate…
View article: Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Background Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms und…
View article: An epigenome-wide association study of child appetitive traits and DNA methylation
An epigenome-wide association study of child appetitive traits and DNA methylation Open
Childhood appetitive traits are consistently associated with obesity risk, and yet their etiology is poorly understood. Appetitive traits are complex phenotypes which are hypothesized to be influenced by both genetic and environmental fact…
View article: Machine learning reveals common transcriptomic signatures across rat brain and placenta following developmental organophosphate ester exposure
Machine learning reveals common transcriptomic signatures across rat brain and placenta following developmental organophosphate ester exposure Open
Toxicogenomics is a critical area of inquiry for hazard identification and to identify both mechanisms of action and potential markers of exposure to toxic compounds. However, data generated by these experiments are highly dimensional and …
View article: LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response
LncRNA Tuna is activated in cadmium-induced placental insufficiency and drives the NRF2-mediated oxidative stress response Open
Cadmium (Cd) is a toxic heavy metal found throughout the environment and one of the top ten toxicants of major public health concern identified by the World Health Organization. In utero Cd exposure causes fetal growth restriction, malform…
View article: Data from Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis
Data from Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis Open
Lipolysis-stimulated lipoprotein receptor (LSR) has been found in the plasma membrane and is believed to function in lipoprotein endocytosis and tight junctions. Given the impact of cellular metabolism and junction signaling pathways on tu…
View article: Supplementary Information from Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis
Supplementary Information from Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis Open
Supplementary Information including supplementary figure legends and supplementary table titles
View article: Supplementary Tables from Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis
Supplementary Tables from Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis Open
Supplementary Table 1. Mutations in LSR from Human Cancer Samples. Supplementary Table 2. Potential post-translational modification sites of LSR transcript variants.
View article: Supplementary Information from Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis
Supplementary Information from Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis Open
Supplementary Information including supplementary figure legends and supplementary table titles
View article: Supplementary Figures from Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis
Supplementary Figures from Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis Open
S1. QPCR analysis of luminal progenitor and cancer stem cell genes. Primers were designed against the indicated genes. S2. Representative Z-stack projections of MCF7 breast cancer and MCF10AI breast epithelial cells generated from deconvol…
View article: Data from Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis
Data from Nuclear Localized LSR: A Novel Regulator of Breast Cancer Behavior and Tumorigenesis Open
Lipolysis-stimulated lipoprotein receptor (LSR) has been found in the plasma membrane and is believed to function in lipoprotein endocytosis and tight junctions. Given the impact of cellular metabolism and junction signaling pathways on tu…