Derek A. Dionne
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View article: Dynamic Ins2 gene activity defines β-cell maturity states
Dynamic Ins2 gene activity defines β-cell maturity states Open
Transcriptional and functional cellular specialization has been described for insulin-secreting β-cells of the endocrine pancreas. However, it is not clear whether β-cell heterogeneity is stable or reflects dynamic cellular states. We inve…
View article: Dynamic <i>Ins2</i> Gene Activity Defines β-Cell Maturity States
Dynamic <i>Ins2</i> Gene Activity Defines β-Cell Maturity States Open
Transcriptional and functional cellular specialization has been described for insulin-secreting β-cells of the endocrine pancreas. However, it is not clear whether β-cell heterogeneity is stable or reflects dynamic cellular states. We inve…
View article: Dynamic Ins2 gene activity defines β-cell maturity states
Dynamic Ins2 gene activity defines β-cell maturity states Open
Transcriptional and functional cellular specialization has been described for insulin-secreting β-cells of the endocrine pancreas. However, it is not clear whether β-cell heterogeneity is stable or reflects dynamic cellular states. We inve…
View article: Dynamic Ins2 gene activity defines β-cell maturity states
Dynamic Ins2 gene activity defines β-cell maturity states Open
Transcriptional and functional cellular specialization has been described for insulin-secreting β-cells of the endocrine pancreas. However, it is not clear whether β-cell heterogeneity is stable or reflects dynamic cellular states. We inve…
View article: Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition
Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition Open
The endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) helps decide cell survival in diabetes. The alternative eukaryotic initiation factor 2A (EIF2A) has been proposed to mediate EIF2S1-independent translation durin…
View article: Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition
Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition Open
The endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) helps decide β cell survival in diabetes. The alternative eukaryotic initiation factor 2A (EIF2A) has been proposed to mediate EIF2S1-independent translation dur…
View article: Metabolic effects of short-term caloric restriction in mice with reduced insulin gene dosage
Metabolic effects of short-term caloric restriction in mice with reduced insulin gene dosage Open
Caloric restriction (CR) is the only environmental intervention with robust evidence that it extends lifespan and delays the symptoms of aging, but its mechanisms are incompletely understood. Based on the prolonged longevity of knockout mo…
View article: Reducing insulin via conditional partial gene ablation in adults reverses diet‐induced weight gain
Reducing insulin via conditional partial gene ablation in adults reverses diet‐induced weight gain Open
Excess circulating insulin is associated with obesity in humans and in animal models. However, the physiologic causality of hyperinsulinemia in adult obesity has rightfully been questioned because of the absence of clear evidence that weig…
View article: Caloric Restriction Paradoxically Increases Adiposity in Mice With Genetically Reduced Insulin
Caloric Restriction Paradoxically Increases Adiposity in Mice With Genetically Reduced Insulin Open
Antiadiposity effects of caloric restriction (CR) are associated with reduced insulin/IGF-1 signaling, but it is unclear whether the effects of CR would be additive to genetically reducing circulating insulin. To address this question, we …