D. R. Ball
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View article: Continuous heart rate variability monitoring, stress and recovery in doctors: a systematic review and meta-analysis
Continuous heart rate variability monitoring, stress and recovery in doctors: a systematic review and meta-analysis Open
Background Burnout is a rising concern among doctors. Heart rate variability (HRV), a non-invasive measure of autonomic nervous system activity, can reflect physiological states of sympathetic (stress) and parasympathetic (recovery) nervou…
View article: Continuous heart rate variability monitoring—understanding patterns of stress and recovery and their relationship with self-reported burnout, resilience and well-being in doctors: a protocol for a sequential explanatory mixed-methods study
Continuous heart rate variability monitoring—understanding patterns of stress and recovery and their relationship with self-reported burnout, resilience and well-being in doctors: a protocol for a sequential explanatory mixed-methods study Open
Introduction The medical profession is facing an unprecedented crisis. Reasons for this are complex and multifactorial; however, rising rates of burnout will undoubtedly contribute to problems with recruitment and retention. Chronic workpl…
View article: Intramuscular pH monitoring before and during exercise in individuals with intermittent claudication compared to healthy controls: A feasibility study
Intramuscular pH monitoring before and during exercise in individuals with intermittent claudication compared to healthy controls: A feasibility study Open
Objective In this feasibility study, firstly, we aimed to assess whether intramuscular pH (IMpH) could be measured with a glass-tipped electrode. Secondly, we aimed to explore whether we could monitor changes in skeletal muscle pH before a…
View article: Ordered magnetic fields around the 3C 84 central black hole
Ordered magnetic fields around the 3C 84 central black hole Open
Context. 3C 84 is a nearby radio source with a complex total intensity structure, showing linear polarisation and spectral patterns. A detailed investigation of the central engine region necessitates the use of very-long-baseline interfero…
View article: Fatigue as a limitation to performance
Fatigue as a limitation to performance Open
Scientific interest in the nature and causes of exercise-induced fatigue developed through the 19th century, culminating in the publication in 1891 of a monograph on the subject by Angelo Mosso (Mosso, 1891). Mosso had developed an ergogra…
View article: The Variability of the Black-Hole Image in M87 at the Dynamical Time Scale
The Variability of the Black-Hole Image in M87 at the Dynamical Time Scale Open
The black-hole images obtained with the Event Horizon Telescope (EHT) are expected to be variable at the dynamical timescale near their horizons. For the black hole at the center of the M87 galaxy, this timescale (5-61 days) is comparable …
View article: Understanding the interplay between the gut microbiome, nutrition and health
Understanding the interplay between the gut microbiome, nutrition and health Open
The Spring Conference 2021 focused on the theme of the gut microbiome and health that was divided across three separate but inter-related areas from the impact of nutrition on the gut microbiome, the cause and effect of nutrition and healt…
View article: Initial fitness, maturity status, and total training explain small and inconsistent proportions of the variance in physical development of adolescent footballers across one season
Initial fitness, maturity status, and total training explain small and inconsistent proportions of the variance in physical development of adolescent footballers across one season Open
To investigate how initial fitness, maturity status, and training time explain changes in physical performance across one season. Eighty-eight adolescent male footballers, representing four age categories (Under 15 [n = 12], Under 14 [n = …
View article: Conference report: the importance of the gut microbiome and nutrition on health
Conference report: the importance of the gut microbiome and nutrition on health Open
The Nutrition Society Spring Conference (28–29 March 2021) focussed on the gut microbiome and health that was divided across three separate but inter-related areas from the impact of nutrition on the gut microbiome, the cause and effect of…
View article: PHOSPHO1, a novel skeletal regulator of insulin resistance and obesity
PHOSPHO1, a novel skeletal regulator of insulin resistance and obesity Open
The skeleton is recognised as a key endocrine regulator of metabolism. Here we show that mice lacking the bone mineralization enzyme PHOSPHO1 ( Phospho1 -/- ) exhibited improved basal glucose homeostasis and resisted high-fat-diet induced …
View article: Additional file 11 of PHOSPHO1 is a skeletal regulator of insulin resistance and obesity
Additional file 11 of PHOSPHO1 is a skeletal regulator of insulin resistance and obesity Open
Additional file 11. Raw data.
View article: Additional file 6 of PHOSPHO1 is a skeletal regulator of insulin resistance and obesity
Additional file 6 of PHOSPHO1 is a skeletal regulator of insulin resistance and obesity Open
Additional file 6: Table S6. Osteoblast microarray candidates involved associated with glucose homeostasis. 21 genes from the WT and Phospho1−/− osteoblast microarray were identified by Ingenuity Pathway Analysis to be associated with gluc…
View article: Additional file 7 of PHOSPHO1 is a skeletal regulator of insulin resistance and obesity
Additional file 7 of PHOSPHO1 is a skeletal regulator of insulin resistance and obesity Open
Additional file 7: Table S7. In Silico analysis of Ingenuity pathways predictions In Silico analysis of genes predicated to be associated with bone and diabetes mellitus.
View article: Additional file 9 of PHOSPHO1 is a skeletal regulator of insulin resistance and obesity
Additional file 9 of PHOSPHO1 is a skeletal regulator of insulin resistance and obesity Open
Additional file 9: Table S9. In Silico analysis top diseases associated with unique WT HFD and Phospho1−/− HFD proteins. (CSV 3 kb)
View article: SYMBA: An end-to-end VLBI synthetic data generation pipeline. Simulating Event Horizon Telescope observations of M 87
SYMBA: An end-to-end VLBI synthetic data generation pipeline. Simulating Event Horizon Telescope observations of M 87 Open
Context. Realistic synthetic observations of theoretical source models are essential for our understanding of real observational data. In using synthetic data, one can verify the extent to which source parameters can be recovered and evalu…
View article: SYMBA: An end-to-end VLBI synthetic data generation pipeline
SYMBA: An end-to-end VLBI synthetic data generation pipeline Open
Context. Realistic synthetic observations of theoretical source models are essential for our understanding of real observational data. In using synthetic data, one can verify the extent to which source parameters can be recovered and evalu…
View article: Remote sensing of blood oxygenation using red-eye pupil reflection
Remote sensing of blood oxygenation using red-eye pupil reflection Open
We describe a new method to remotely and non-invasively sense the oxygen saturation of choroidal blood. The methodology provides a proxy for remote sensing of cerebral and systemic blood oxygenation. We demonstrate the technique at short r…
View article: Determining Ischaemic Thresholds Through Our Understanding of Cellular Metabolism
Determining Ischaemic Thresholds Through Our Understanding of Cellular Metabolism Open
Background to the Chapter• Synopsis of clinical issues associated with the complexity of compartment syndromes and current diagnostic limitations • Comprehending the metabolic capacity of active skeletal muscle and its constant need for en…
View article: P9 Hyperpolarised ketone body metabolism in the rat heart
P9 Hyperpolarised ketone body metabolism in the rat heart Open
Hyperpolarised Magnetic Resonance Spectroscopy (MRS) permits the real time determination of metabolic fluxes in the living heart. In contrast to conventional thermal-equilibrium MRS, the hyperpolarisation technique increases the signal-to-…
View article: The interaction between nutrition and exercise for promoting health and performance
The interaction between nutrition and exercise for promoting health and performance Open
The theme of The Nutrition Society Spring Conference 2017 was on the interaction between nutrition and exercise for promoting healthy ageing, maintaining cognitive function and improving the metabolic health of the population. The importan…
View article: P68 To screen or not to screen for Obstructive Sleep Apnoea (OSA) pre-operatively?
P68 To screen or not to screen for Obstructive Sleep Apnoea (OSA) pre-operatively? Open
Background Anaesthesia worsens OSA, and may lead to respiratory and cardiac complications. Three critical incidents have occurred in the Oxford Hospitals in recent years. OSA is very common at around 5–25%, but half the cases are not diagn…
View article: Universal neuromuscular blockade monitoring – a reply
Universal neuromuscular blockade monitoring – a reply Open
We thank Dr. Levy for his interest in our editorial 1, and welcome his support for the principle of neuromuscular monitoring for all patients receiving neuromuscular blocking drugs, applied from the start of the case, activated after induc…
View article: Collecting safety data on procedural sedation
Collecting safety data on procedural sedation Open
We congratulate the South Western Anaesthetic Research Matrix (SWARM) for their two-day regional sprint survey of sedation practice in six acute hospital trusts within the South West Peninsula 1. Data collection focused on the process of s…
View article: Death of the anaesthetic room IV
Death of the anaesthetic room IV Open
Drs Frerk and Pinder provide a useful table of advantages and disadvantages of using anaesthetic rooms for induction 1. Further advantages to inducing anaesthesia in the operating room 2 include improved conduct of the Safer Surgery checkl…
View article: Awake nasal intubation: the gag reflex and failure of videolaryngoscopy
Awake nasal intubation: the gag reflex and failure of videolaryngoscopy Open
In their comparative study of fibreoptic and videolaryngoscope-guided awake nasotracheal intubation, Kramer and colleagues report an equal failure rate (4%) in each group, but for different reasons 1. Failure in the videolaryngoscope group…